Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease
Abnormal trinucleotide CAG repeat expansions in exon 1 of the Androgen Receptor (AR) gene has been identified as the cause of Kennedy disease (KD). We generated and characterized a human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) of a patient with geneti...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506124003362 |
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| author | Bo Li Yitong Yang Yingxin Wang Didi Shan Jianing Li Hongxu Wang Xiaohan Sun Yao Tang Yichang Jiao Xinbo Ji Zexin Zhan Bo Kong Bo Gao Yu Wang Ping Sun Fuchen Liu |
| author_facet | Bo Li Yitong Yang Yingxin Wang Didi Shan Jianing Li Hongxu Wang Xiaohan Sun Yao Tang Yichang Jiao Xinbo Ji Zexin Zhan Bo Kong Bo Gao Yu Wang Ping Sun Fuchen Liu |
| author_sort | Bo Li |
| collection | DOAJ |
| description | Abnormal trinucleotide CAG repeat expansions in exon 1 of the Androgen Receptor (AR) gene has been identified as the cause of Kennedy disease (KD). We generated and characterized a human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) of a patient with genetically confirmed KD. The pluripotency of these iPSCs was verified by the expression of several pluripotency markers at both RNA and protein levels, as well as their capability to differentiate into all three germ layers. |
| format | Article |
| id | doaj-art-e4761add898a4b418e9d551745aed0f9 |
| institution | Kabale University |
| issn | 1873-5061 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj-art-e4761add898a4b418e9d551745aed0f92025-01-13T04:18:42ZengElsevierStem Cell Research1873-50612025-02-0182103638Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy diseaseBo Li0Yitong Yang1Yingxin Wang2Didi Shan3Jianing Li4Hongxu Wang5Xiaohan Sun6Yao Tang7Yichang Jiao8Xinbo Ji9Zexin Zhan10Bo Kong11Bo Gao12Yu Wang13Ping Sun14Fuchen Liu15Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaSchool of Nursing, Jining Medical University, Jining, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, ChinaDepartment of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaDepartment of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, Shandong, ChinaPrenatal Diagnostic Center of Obstetrics and Department of Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaPrenatal Diagnostic Center of Obstetrics and Department of Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, ChinaDepartment of Neurology, Research Institute of Neuromuscular and Neurodegenerative Diseases, Shandong Key Laboratory of Mitochondrial Medicine and Rare Diseases, Jinan, Shandong, China; Corresponding author.Abnormal trinucleotide CAG repeat expansions in exon 1 of the Androgen Receptor (AR) gene has been identified as the cause of Kennedy disease (KD). We generated and characterized a human induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMC) of a patient with genetically confirmed KD. The pluripotency of these iPSCs was verified by the expression of several pluripotency markers at both RNA and protein levels, as well as their capability to differentiate into all three germ layers.http://www.sciencedirect.com/science/article/pii/S1873506124003362 |
| spellingShingle | Bo Li Yitong Yang Yingxin Wang Didi Shan Jianing Li Hongxu Wang Xiaohan Sun Yao Tang Yichang Jiao Xinbo Ji Zexin Zhan Bo Kong Bo Gao Yu Wang Ping Sun Fuchen Liu Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease Stem Cell Research |
| title | Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease |
| title_full | Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease |
| title_fullStr | Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease |
| title_full_unstemmed | Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease |
| title_short | Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease |
| title_sort | generation of an induced pluripotent stem cell ipsc line inndsui007 a from a patient with kennedy disease |
| url | http://www.sciencedirect.com/science/article/pii/S1873506124003362 |
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