Synthesis, target analysis, and cerebroprotective effects of novel imide antioxidants via the Nrf2/HO-1 pathway in cerebral ischemia-reperfusion injury

Synthesis, target analysis, and cerebroprotective effects of novel imide antioxidants via the Nrf2/HO-1 pathway in cerebral ischemia-reperfusion injury

BackgroundCerebral ischemia-reperfusion injury (CIRI) is a secondary brain injury that occurs after thrombolysis and is a primary cause of death in ischemic stroke patients. Antioxidants that effectively reduce oxidative stress are an efficient treatment approach for CIRI. Here, a novel diimide comp...

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Bibliographic Details
Main Authors: Lili Huang, Yinqi Chen, Hua Zhou, Huihui Chen, Xiping Wu, Zhuochao Wu, Zhoudi Liu, Zhiwei Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
cerebral ischemia-reperfusion injury
oxidative stress
antioxidant
network pharmacology
molecular docking
Nrf2 signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1552717/full
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