New Possibilities for Overcoming Antibiotic Resistance in Bacteria
Antibiotic resistance remains one of the most significant barriers to successful treatment of bacterial diseases. The microorganisms present in biofilms develop antimicrobial resistance much faster and more powerfully than planktonic forms. With the help of «quorum sensing», bacteria in biofilms exc...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2025-04-01
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| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/1214 |
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| _version_ | 1849692966815268864 |
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| author | A. N. Gratsianskaya N. V. Teplova L. B. Belousova |
| author_facet | A. N. Gratsianskaya N. V. Teplova L. B. Belousova |
| author_sort | A. N. Gratsianskaya |
| collection | DOAJ |
| description | Antibiotic resistance remains one of the most significant barriers to successful treatment of bacterial diseases. The microorganisms present in biofilms develop antimicrobial resistance much faster and more powerfully than planktonic forms. With the help of «quorum sensing», bacteria in biofilms exchange information with each other to maximize their pathogenicity. This review examines the main mechanisms of antibiotic resistance, the structure and vital activity of biofilms, the mechanisms of the «sense of quorum», as well as possible ways to overcome antibiotic-resistant bacterial resistance due to the effect of suppressing the «sense of quorum». |
| format | Article |
| id | doaj-art-e46dde7be3fb42c0b478c82cc7639340 |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2025-04-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-e46dde7be3fb42c0b478c82cc76393402025-08-20T03:20:33ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902025-04-016911-1212112610.37489/0235-2990-2024-69-11-12-121-1261084New Possibilities for Overcoming Antibiotic Resistance in BacteriaA. N. Gratsianskaya0N. V. Teplova1L. B. Belousova2Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian Federation (Pirogov University)Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian Federation (Pirogov University)Russian National Research Medical University named after N. I. Pirogov of the Ministry of Health of the Russian Federation (Pirogov University)Antibiotic resistance remains one of the most significant barriers to successful treatment of bacterial diseases. The microorganisms present in biofilms develop antimicrobial resistance much faster and more powerfully than planktonic forms. With the help of «quorum sensing», bacteria in biofilms exchange information with each other to maximize their pathogenicity. This review examines the main mechanisms of antibiotic resistance, the structure and vital activity of biofilms, the mechanisms of the «sense of quorum», as well as possible ways to overcome antibiotic-resistant bacterial resistance due to the effect of suppressing the «sense of quorum».https://www.antibiotics-chemotherapy.ru/jour/article/view/1214biofilmsantibiotic resistancequorum sensingantimicrobial peptidesinhibitorsmonoclonal antibodies |
| spellingShingle | A. N. Gratsianskaya N. V. Teplova L. B. Belousova New Possibilities for Overcoming Antibiotic Resistance in Bacteria Антибиотики и Химиотерапия biofilms antibiotic resistance quorum sensing antimicrobial peptides inhibitors monoclonal antibodies |
| title | New Possibilities for Overcoming Antibiotic Resistance in Bacteria |
| title_full | New Possibilities for Overcoming Antibiotic Resistance in Bacteria |
| title_fullStr | New Possibilities for Overcoming Antibiotic Resistance in Bacteria |
| title_full_unstemmed | New Possibilities for Overcoming Antibiotic Resistance in Bacteria |
| title_short | New Possibilities for Overcoming Antibiotic Resistance in Bacteria |
| title_sort | new possibilities for overcoming antibiotic resistance in bacteria |
| topic | biofilms antibiotic resistance quorum sensing antimicrobial peptides inhibitors monoclonal antibodies |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/1214 |
| work_keys_str_mv | AT angratsianskaya newpossibilitiesforovercomingantibioticresistanceinbacteria AT nvteplova newpossibilitiesforovercomingantibioticresistanceinbacteria AT lbbelousova newpossibilitiesforovercomingantibioticresistanceinbacteria |