Research advances of shrunken pore syndrome
As a pathophysiologic state in the absence of extrarenal influences on cystatin C or creatinine concentration，shrunken pore syndrome （SPS） occurs when estimated glomerular filtration rate （eGFR） based upon plasma cystatin C becomes significantly lower than its counterpart based upon creatinine. Stud...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Clinical Nephrology
2022-03-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.03.011 |
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| _version_ | 1849312453156929536 |
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| author | Zhang Pei Zhuo Hua Yang Min |
| author_facet | Zhang Pei Zhuo Hua Yang Min |
| author_sort | Zhang Pei |
| collection | DOAJ |
| description | As a pathophysiologic state in the absence of extrarenal influences on cystatin C or creatinine concentration，shrunken pore syndrome （SPS） occurs when estimated glomerular filtration rate （eGFR） based upon plasma cystatin C becomes significantly lower than its counterpart based upon creatinine. Studies have demonstrated that SPS patients have a poor prognosis and carry a high risk for cardiovascular morbidity and mortality. A potential mechanism of SPS is associated with a reduction of pore size of glomerular filtration membrane and a lower glomerular filtration of molecules 5~30，000. Corresponding treatment is thus proposed based upon the conjecture. This review summarized the latest researches in pathophysiological mechanism，diagnosis & treatment and clinical outcomes of SPS. It was intended to enhance its clinical awareness and boost the capability of its early identification. |
| format | Article |
| id | doaj-art-e46cef112e8143cf88d5d0a60f787a0d |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2022-03-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-e46cef112e8143cf88d5d0a60f787a0d2025-08-20T03:53:03ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902022-03-012223824223927499Research advances of shrunken pore syndromeZhang PeiZhuo HuaYang MinAs a pathophysiologic state in the absence of extrarenal influences on cystatin C or creatinine concentration，shrunken pore syndrome （SPS） occurs when estimated glomerular filtration rate （eGFR） based upon plasma cystatin C becomes significantly lower than its counterpart based upon creatinine. Studies have demonstrated that SPS patients have a poor prognosis and carry a high risk for cardiovascular morbidity and mortality. A potential mechanism of SPS is associated with a reduction of pore size of glomerular filtration membrane and a lower glomerular filtration of molecules 5~30，000. Corresponding treatment is thus proposed based upon the conjecture. This review summarized the latest researches in pathophysiological mechanism，diagnosis & treatment and clinical outcomes of SPS. It was intended to enhance its clinical awareness and boost the capability of its early identification.http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.03.011Cystatin CCreatinineGlomerular filtration rateGlomerular filtration membraneShrunken pore syndrome |
| spellingShingle | Zhang Pei Zhuo Hua Yang Min Research advances of shrunken pore syndrome Linchuang shenzangbing zazhi Cystatin C Creatinine Glomerular filtration rate Glomerular filtration membrane Shrunken pore syndrome |
| title | Research advances of shrunken pore syndrome |
| title_full | Research advances of shrunken pore syndrome |
| title_fullStr | Research advances of shrunken pore syndrome |
| title_full_unstemmed | Research advances of shrunken pore syndrome |
| title_short | Research advances of shrunken pore syndrome |
| title_sort | research advances of shrunken pore syndrome |
| topic | Cystatin C Creatinine Glomerular filtration rate Glomerular filtration membrane Shrunken pore syndrome |
| url | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.03.011 |
| work_keys_str_mv | AT zhangpei researchadvancesofshrunkenporesyndrome AT zhuohua researchadvancesofshrunkenporesyndrome AT yangmin researchadvancesofshrunkenporesyndrome |