Transcriptional landscape of small non-coding RNAs reveals diversity of categories and functions in molluscs
Small non-coding RNAs (sncRNAs) are non-coding RNA molecules that play various roles in metazoans. Among the sncRNAs, microRNAs (miRNAs) guide post-translational gene regulation during cellular development, proliferation, apoptosis, and differentiation, while PIWI-interacting RNAs (piRNAs) suppress...
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| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | RNA Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2024.2348893 |
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| author | Songqian Huang Kazutoshi Yoshitake Shigeharu Kinoshita Shuichi Asakawa |
| author_facet | Songqian Huang Kazutoshi Yoshitake Shigeharu Kinoshita Shuichi Asakawa |
| author_sort | Songqian Huang |
| collection | DOAJ |
| description | Small non-coding RNAs (sncRNAs) are non-coding RNA molecules that play various roles in metazoans. Among the sncRNAs, microRNAs (miRNAs) guide post-translational gene regulation during cellular development, proliferation, apoptosis, and differentiation, while PIWI-interacting RNAs (piRNAs) suppress transposon activity to safeguard the genome from detrimental insertion mutagenesis. While an increasing number of piRNAs are being identified in the soma and germlines of various organisms, they are scarcely reported in molluscs. To unravel the small RNA (sRNA) expression patterns and genomic function in molluscs, we generated a comprehensive sRNA dataset by sRNA sequencing (sRNA-seq) of eight mollusc species. Abundant miRNAs were identified and characterized in all investigated molluscs, and ubiquitous piRNAs were discovered in both somatic and gonadal tissues in six of the investigated molluscs, which are more closely associated with transposon silencing. Tens of piRNA clusters were also identified based on the genomic mapping results, which varied among different tissues and species. Our dataset serves as important reference data for future genomic and genetic studies on sRNAs in these molluscs and related species, especially in elucidating the ancestral state of piRNAs in bilaterians. |
| format | Article |
| id | doaj-art-e46856b75021470baec3abfeeb74130d |
| institution | OA Journals |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-e46856b75021470baec3abfeeb74130d2025-08-20T01:54:54ZengTaylor & Francis GroupRNA Biology1547-62861555-85842024-12-0121153054210.1080/15476286.2024.2348893Transcriptional landscape of small non-coding RNAs reveals diversity of categories and functions in molluscsSongqian Huang0Kazutoshi Yoshitake1Shigeharu Kinoshita2Shuichi Asakawa3International Research Center for Marine Biosciences, Ministry of Science and Technology, College of Fisheries and Life Sciences, Shanghai Ocean University, Shanghai, ChinaDepartment of Aquatic Bioscience, Graduate School of Agricultural and Life Science, The University of Tokyo, Tokyo, JapanDepartment of Aquatic Bioscience, Graduate School of Agricultural and Life Science, The University of Tokyo, Tokyo, JapanDepartment of Aquatic Bioscience, Graduate School of Agricultural and Life Science, The University of Tokyo, Tokyo, JapanSmall non-coding RNAs (sncRNAs) are non-coding RNA molecules that play various roles in metazoans. Among the sncRNAs, microRNAs (miRNAs) guide post-translational gene regulation during cellular development, proliferation, apoptosis, and differentiation, while PIWI-interacting RNAs (piRNAs) suppress transposon activity to safeguard the genome from detrimental insertion mutagenesis. While an increasing number of piRNAs are being identified in the soma and germlines of various organisms, they are scarcely reported in molluscs. To unravel the small RNA (sRNA) expression patterns and genomic function in molluscs, we generated a comprehensive sRNA dataset by sRNA sequencing (sRNA-seq) of eight mollusc species. Abundant miRNAs were identified and characterized in all investigated molluscs, and ubiquitous piRNAs were discovered in both somatic and gonadal tissues in six of the investigated molluscs, which are more closely associated with transposon silencing. Tens of piRNA clusters were also identified based on the genomic mapping results, which varied among different tissues and species. Our dataset serves as important reference data for future genomic and genetic studies on sRNAs in these molluscs and related species, especially in elucidating the ancestral state of piRNAs in bilaterians.https://www.tandfonline.com/doi/10.1080/15476286.2024.2348893miRNAspiRNAsgene regulationtransposon silencingmolluscs |
| spellingShingle | Songqian Huang Kazutoshi Yoshitake Shigeharu Kinoshita Shuichi Asakawa Transcriptional landscape of small non-coding RNAs reveals diversity of categories and functions in molluscs RNA Biology miRNAs piRNAs gene regulation transposon silencing molluscs |
| title | Transcriptional landscape of small non-coding RNAs reveals diversity of categories and functions in molluscs |
| title_full | Transcriptional landscape of small non-coding RNAs reveals diversity of categories and functions in molluscs |
| title_fullStr | Transcriptional landscape of small non-coding RNAs reveals diversity of categories and functions in molluscs |
| title_full_unstemmed | Transcriptional landscape of small non-coding RNAs reveals diversity of categories and functions in molluscs |
| title_short | Transcriptional landscape of small non-coding RNAs reveals diversity of categories and functions in molluscs |
| title_sort | transcriptional landscape of small non coding rnas reveals diversity of categories and functions in molluscs |
| topic | miRNAs piRNAs gene regulation transposon silencing molluscs |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2024.2348893 |
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