Optimizing Infliximab Use in Real-World Inflammatory Bowel Disease: Insights from a Population Pharmacokinetic Model Integrating Intravenous and Subcutaneous Formulations
Background/Aims: The prognostic value of serial 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG PET/CT) for patients with borderline resectable or locally advanced pancreatic cancer who undergo conversion surgery or continue chemotherapy without surgery has not been...
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| Language: | English |
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Gastroenterology Council for Gut and Liver
2025-05-01
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| Series: | Gut and Liver |
| Online Access: | http://gutnliver.org/journal/view.html?doi=10.5009/gnl250154 |
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| author | Sung Hoon Jung Sang-Bum Kang |
| author_facet | Sung Hoon Jung Sang-Bum Kang |
| author_sort | Sung Hoon Jung |
| collection | DOAJ |
| description | Background/Aims: The prognostic value of serial 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG PET/CT) for patients with borderline resectable or locally advanced pancreatic cancer who undergo conversion surgery or continue chemotherapy without surgery has not been well-established. Methods: A retrospective analysis of patients with pancreatic ductal adenocarcinoma was conducted at Seoul National University Bundang Hospital between March 2013 and February 2022. Patients underwent PET/CT at baseline and subsequent radiologic evaluations following chemotherapy. Changes in the maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume, and total lesion glycolysis were analyzed. Based on their treatment regimens, patients were stratified into the conversion surgery group or nonconversion surgery group. Survival outcomes and various clinical factors were assessed. Results: Among 121 patients, 52 underwent conversion surgery, and 69 continued to receive chemotherapy without surgery. A significant reduction in the SUVmax was correlated with prolonged recurrence-free survival and overall survival in the conversion surgery group. Confirmation of a pathologic response indicated a significant association between reductions in the SUVmax and positive outcomes. Reductions in the metabolic tumor volume and total lesion glycolysis were associated with improved progression-free survival and overall survival in the nonconversion surgery group. Conclusions: Serial PET/CT scans demonstrated prognostic value in pancreatic ductal adenocarcinoma patients, revealing distinct correlations in the conversion surgery group and nonconversion surgery group. |
| format | Article |
| id | doaj-art-e4620e80ae13449785be41f7c6713297 |
| institution | DOAJ |
| issn | 1976-2283 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Gastroenterology Council for Gut and Liver |
| record_format | Article |
| series | Gut and Liver |
| spelling | doaj-art-e4620e80ae13449785be41f7c67132972025-08-20T02:59:10ZengGastroenterology Council for Gut and LiverGut and Liver1976-22832025-05-0119329930010.5009/gnl250154gnl250154Optimizing Infliximab Use in Real-World Inflammatory Bowel Disease: Insights from a Population Pharmacokinetic Model Integrating Intravenous and Subcutaneous FormulationsSung Hoon Jung0Sang-Bum Kang1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, KoreaDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, KoreaBackground/Aims: The prognostic value of serial 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG PET/CT) for patients with borderline resectable or locally advanced pancreatic cancer who undergo conversion surgery or continue chemotherapy without surgery has not been well-established. Methods: A retrospective analysis of patients with pancreatic ductal adenocarcinoma was conducted at Seoul National University Bundang Hospital between March 2013 and February 2022. Patients underwent PET/CT at baseline and subsequent radiologic evaluations following chemotherapy. Changes in the maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume, and total lesion glycolysis were analyzed. Based on their treatment regimens, patients were stratified into the conversion surgery group or nonconversion surgery group. Survival outcomes and various clinical factors were assessed. Results: Among 121 patients, 52 underwent conversion surgery, and 69 continued to receive chemotherapy without surgery. A significant reduction in the SUVmax was correlated with prolonged recurrence-free survival and overall survival in the conversion surgery group. Confirmation of a pathologic response indicated a significant association between reductions in the SUVmax and positive outcomes. Reductions in the metabolic tumor volume and total lesion glycolysis were associated with improved progression-free survival and overall survival in the nonconversion surgery group. Conclusions: Serial PET/CT scans demonstrated prognostic value in pancreatic ductal adenocarcinoma patients, revealing distinct correlations in the conversion surgery group and nonconversion surgery group.http://gutnliver.org/journal/view.html?doi=10.5009/gnl250154 |
| spellingShingle | Sung Hoon Jung Sang-Bum Kang Optimizing Infliximab Use in Real-World Inflammatory Bowel Disease: Insights from a Population Pharmacokinetic Model Integrating Intravenous and Subcutaneous Formulations Gut and Liver |
| title | Optimizing Infliximab Use in Real-World Inflammatory Bowel Disease: Insights from a Population Pharmacokinetic Model Integrating Intravenous and Subcutaneous Formulations |
| title_full | Optimizing Infliximab Use in Real-World Inflammatory Bowel Disease: Insights from a Population Pharmacokinetic Model Integrating Intravenous and Subcutaneous Formulations |
| title_fullStr | Optimizing Infliximab Use in Real-World Inflammatory Bowel Disease: Insights from a Population Pharmacokinetic Model Integrating Intravenous and Subcutaneous Formulations |
| title_full_unstemmed | Optimizing Infliximab Use in Real-World Inflammatory Bowel Disease: Insights from a Population Pharmacokinetic Model Integrating Intravenous and Subcutaneous Formulations |
| title_short | Optimizing Infliximab Use in Real-World Inflammatory Bowel Disease: Insights from a Population Pharmacokinetic Model Integrating Intravenous and Subcutaneous Formulations |
| title_sort | optimizing infliximab use in real world inflammatory bowel disease insights from a population pharmacokinetic model integrating intravenous and subcutaneous formulations |
| url | http://gutnliver.org/journal/view.html?doi=10.5009/gnl250154 |
| work_keys_str_mv | AT sunghoonjung optimizinginfliximabuseinrealworldinflammatoryboweldiseaseinsightsfromapopulationpharmacokineticmodelintegratingintravenousandsubcutaneousformulations AT sangbumkang optimizinginfliximabuseinrealworldinflammatoryboweldiseaseinsightsfromapopulationpharmacokineticmodelintegratingintravenousandsubcutaneousformulations |