Wnt/β-catenin and notch signaling pathways in cardiovascular disease: Mechanisms and therapeutics approaches
Wnt and Notch signaling pathways play crucial roles in the development and homeostasis of the cardiovascular system. These pathways regulate important cellular processes in cardiomyocytes, endothelial cells, and smooth muscle cells, which are the key cell types involved in the structure and function...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661824005103 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841553854966005760 |
|---|---|
| author | Manizheh Azhdari Axel zur Hausen |
| author_facet | Manizheh Azhdari Axel zur Hausen |
| author_sort | Manizheh Azhdari |
| collection | DOAJ |
| description | Wnt and Notch signaling pathways play crucial roles in the development and homeostasis of the cardiovascular system. These pathways regulate important cellular processes in cardiomyocytes, endothelial cells, and smooth muscle cells, which are the key cell types involved in the structure and function of the heart and vasculature. During embryonic development, Wnt and Notch signaling coordinate cell fate specification, proliferation, differentiation, and morphogenesis of the heart and blood vessels. In the adult cardiovascular system, these pathways continue to maintain tissue homeostasis and arrange adaptive responses to various physiological and pathological stimuli. Dysregulation of Wnt and Notch signaling has been involved in the pathogenesis of numerous cardiovascular diseases, including atherosclerosis, hypertension, myocardial infarction, and heart failure. Abnormal activation or suppression of these pathways in specific cell types can contribute to endothelial dysfunction, vascular remodeling, cardiomyocyte hypertrophy, impaired cardiac contractility and dead. Understanding the complex interplay between Wnt and Notch signaling in the cardiovascular system has led to the investigation of these pathways as potential therapeutic targets in clinical trials. In conclusion, this review summarizes the current knowledge on the roles of Wnt and Notch signaling in the development and homeostasis of cardiomyocytes, endothelial cells, and smooth muscle cells. It further discusses the dysregulation of these pathways in the context of major cardiovascular diseases and the ongoing clinical investigations targeting Wnt and Notch signaling for therapeutic intervention. |
| format | Article |
| id | doaj-art-e460d72b4817443f9bf6639f58f4d015 |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-e460d72b4817443f9bf6639f58f4d0152025-01-09T06:13:07ZengElsevierPharmacological Research1096-11862025-01-01211107565Wnt/β-catenin and notch signaling pathways in cardiovascular disease: Mechanisms and therapeutics approachesManizheh Azhdari0Axel zur Hausen1Corresponding author.; Pathologie, School for Cardiovascular Diseases, Fac. Health, Medicine and Life Sciences, Maastricht university, MUMC, the NetherlandPathologie, School for Cardiovascular Diseases, Fac. Health, Medicine and Life Sciences, Maastricht university, MUMC, the NetherlandWnt and Notch signaling pathways play crucial roles in the development and homeostasis of the cardiovascular system. These pathways regulate important cellular processes in cardiomyocytes, endothelial cells, and smooth muscle cells, which are the key cell types involved in the structure and function of the heart and vasculature. During embryonic development, Wnt and Notch signaling coordinate cell fate specification, proliferation, differentiation, and morphogenesis of the heart and blood vessels. In the adult cardiovascular system, these pathways continue to maintain tissue homeostasis and arrange adaptive responses to various physiological and pathological stimuli. Dysregulation of Wnt and Notch signaling has been involved in the pathogenesis of numerous cardiovascular diseases, including atherosclerosis, hypertension, myocardial infarction, and heart failure. Abnormal activation or suppression of these pathways in specific cell types can contribute to endothelial dysfunction, vascular remodeling, cardiomyocyte hypertrophy, impaired cardiac contractility and dead. Understanding the complex interplay between Wnt and Notch signaling in the cardiovascular system has led to the investigation of these pathways as potential therapeutic targets in clinical trials. In conclusion, this review summarizes the current knowledge on the roles of Wnt and Notch signaling in the development and homeostasis of cardiomyocytes, endothelial cells, and smooth muscle cells. It further discusses the dysregulation of these pathways in the context of major cardiovascular diseases and the ongoing clinical investigations targeting Wnt and Notch signaling for therapeutic intervention.http://www.sciencedirect.com/science/article/pii/S1043661824005103Wnt/β-cateninNotchCardiovascular diseasesCell signaling pathwaysDevelopmental biologyClinical trials |
| spellingShingle | Manizheh Azhdari Axel zur Hausen Wnt/β-catenin and notch signaling pathways in cardiovascular disease: Mechanisms and therapeutics approaches Pharmacological Research Wnt/β-catenin Notch Cardiovascular diseases Cell signaling pathways Developmental biology Clinical trials |
| title | Wnt/β-catenin and notch signaling pathways in cardiovascular disease: Mechanisms and therapeutics approaches |
| title_full | Wnt/β-catenin and notch signaling pathways in cardiovascular disease: Mechanisms and therapeutics approaches |
| title_fullStr | Wnt/β-catenin and notch signaling pathways in cardiovascular disease: Mechanisms and therapeutics approaches |
| title_full_unstemmed | Wnt/β-catenin and notch signaling pathways in cardiovascular disease: Mechanisms and therapeutics approaches |
| title_short | Wnt/β-catenin and notch signaling pathways in cardiovascular disease: Mechanisms and therapeutics approaches |
| title_sort | wnt β catenin and notch signaling pathways in cardiovascular disease mechanisms and therapeutics approaches |
| topic | Wnt/β-catenin Notch Cardiovascular diseases Cell signaling pathways Developmental biology Clinical trials |
| url | http://www.sciencedirect.com/science/article/pii/S1043661824005103 |
| work_keys_str_mv | AT manizhehazhdari wntbcateninandnotchsignalingpathwaysincardiovasculardiseasemechanismsandtherapeuticsapproaches AT axelzurhausen wntbcateninandnotchsignalingpathwaysincardiovasculardiseasemechanismsandtherapeuticsapproaches |