Intelligent single-cell manipulation: LLMs- and object detection-enhanced active-matrix digital microfluidics

Intelligent single-cell manipulation: LLMs- and object detection-enhanced active-matrix digital microfluidics

Abstract Single-cell analysis is crucial for deciphering cellular heterogeneity and understanding complex biological systems. However, most existing single-cell sample manipulation (SCSM) systems suffer from various drawbacks such as high cost, low throughput, and heavy reliance on human interventio...

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Main Authors: Zhiqiang Jia, Chen Jiang, Jiahao Li, Yacine Belgaid, Mingfeng Ge, Li Li, Siyi Hu, Xing Huang, Tsung-Yi Ho, Wenfei Dong, Zhiwen Yu, Hanbin Ma
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Microsystems & Nanoengineering
Online Access:https://doi.org/10.1038/s41378-025-00962-y
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