Mitochondria embedded in degalactosylated xyloglucan hydrogels to improve mitochondrial transplantation
Mitochondria are the major source of intracellular adenosine triphosphate (ATP) and play an essential role in a plethora of physiological functions, including regulating metabolism and maintaining cellular homeostasis. Mitochondrial dysfunction is associated with the onset of several cardiovascular...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893924001233 |
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| author | Pasquale Picone Emanuela Muscolino Antonella Girgenti Maria Testa Daniela Giacomazza Clelia Dispenza Domenico Nuzzo |
| author_facet | Pasquale Picone Emanuela Muscolino Antonella Girgenti Maria Testa Daniela Giacomazza Clelia Dispenza Domenico Nuzzo |
| author_sort | Pasquale Picone |
| collection | DOAJ |
| description | Mitochondria are the major source of intracellular adenosine triphosphate (ATP) and play an essential role in a plethora of physiological functions, including regulating metabolism and maintaining cellular homeostasis. Mitochondrial dysfunction is associated with the onset of several cardiovascular diseases and, although several approaches currently exist to counteract it, no treatment using mitochondria as a therapeutic target exists to date. Recently, mitochondrial transplantation (MT) has been identified as a potential therapy that leads to increased ATP production, reduced oxidative stress, and improved bioenergetics. MT involves the replacement of damaged mitochondria, following injury or diseases.With MT, mitochondria must survive an inhospitable extracellular environment often characterized by oxidizing agents due to pathological and/or inflammatory conditions. Furthermore, only a small percentage of the injected mitochondria reaches the target site due to dispersion throughout the body.In this work, an MT strategy involving degalactosylated xyloglucan hydrogel encapsulating mitochondria, to overcome MT problems and improve its efficiency, is illustrated for the treatment of cardiovascular damage. The presence of the hydrogel presents the following advantages: improves the health of mitochondria; plays a protective role towards mitochondria from the extracellular environment and oxidative stress; allows for sustained release of viable mitochondria and local transfer into host cells. |
| format | Article |
| id | doaj-art-e44ff2100c1d4eeaa0a1cc3606011631 |
| institution | OA Journals |
| issn | 2666-8939 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj-art-e44ff2100c1d4eeaa0a1cc36060116312025-08-20T02:38:23ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392024-12-01810054310.1016/j.carpta.2024.100543Mitochondria embedded in degalactosylated xyloglucan hydrogels to improve mitochondrial transplantationPasquale Picone0Emanuela Muscolino1Antonella Girgenti2Maria Testa3Daniela Giacomazza4Clelia Dispenza5Domenico Nuzzo6Consiglio Nazionale delle Ricerche, Istituto per la Ricerca e l'Innovazione Biomedica, Via U. La Malfa 153, Palermo 90146, ItalyConsiglio Nazionale delle Ricerche, Istituto di Biofisica, Via U. La Malfa 153, Palermo 90146, Italy; Dipartimento di Ingegneria, Università degli Studi di Palermo, Viale delle Scienze, Bldg 6, Palermo 90128, Italy; Corresponding author.Consiglio Nazionale delle Ricerche, Istituto per la Ricerca e l'Innovazione Biomedica, Via U. La Malfa 153, Palermo 90146, ItalyDipartimento di Ingegneria, Università degli Studi di Palermo, Viale delle Scienze, Bldg 6, Palermo 90128, ItalyConsiglio Nazionale delle Ricerche, Istituto di Biofisica, Via U. La Malfa 153, Palermo 90146, ItalyConsiglio Nazionale delle Ricerche, Istituto di Biofisica, Via U. La Malfa 153, Palermo 90146, Italy; Dipartimento di Ingegneria, Università degli Studi di Palermo, Viale delle Scienze, Bldg 6, Palermo 90128, ItalyConsiglio Nazionale delle Ricerche, Istituto per la Ricerca e l'Innovazione Biomedica, Via U. La Malfa 153, Palermo 90146, ItalyMitochondria are the major source of intracellular adenosine triphosphate (ATP) and play an essential role in a plethora of physiological functions, including regulating metabolism and maintaining cellular homeostasis. Mitochondrial dysfunction is associated with the onset of several cardiovascular diseases and, although several approaches currently exist to counteract it, no treatment using mitochondria as a therapeutic target exists to date. Recently, mitochondrial transplantation (MT) has been identified as a potential therapy that leads to increased ATP production, reduced oxidative stress, and improved bioenergetics. MT involves the replacement of damaged mitochondria, following injury or diseases.With MT, mitochondria must survive an inhospitable extracellular environment often characterized by oxidizing agents due to pathological and/or inflammatory conditions. Furthermore, only a small percentage of the injected mitochondria reaches the target site due to dispersion throughout the body.In this work, an MT strategy involving degalactosylated xyloglucan hydrogel encapsulating mitochondria, to overcome MT problems and improve its efficiency, is illustrated for the treatment of cardiovascular damage. The presence of the hydrogel presents the following advantages: improves the health of mitochondria; plays a protective role towards mitochondria from the extracellular environment and oxidative stress; allows for sustained release of viable mitochondria and local transfer into host cells.http://www.sciencedirect.com/science/article/pii/S2666893924001233MitochondriaHydrogel delivery deviceMitochondrial transplantationDegalactosylated xyloglucanHeart injectionHydrogel injection |
| spellingShingle | Pasquale Picone Emanuela Muscolino Antonella Girgenti Maria Testa Daniela Giacomazza Clelia Dispenza Domenico Nuzzo Mitochondria embedded in degalactosylated xyloglucan hydrogels to improve mitochondrial transplantation Carbohydrate Polymer Technologies and Applications Mitochondria Hydrogel delivery device Mitochondrial transplantation Degalactosylated xyloglucan Heart injection Hydrogel injection |
| title | Mitochondria embedded in degalactosylated xyloglucan hydrogels to improve mitochondrial transplantation |
| title_full | Mitochondria embedded in degalactosylated xyloglucan hydrogels to improve mitochondrial transplantation |
| title_fullStr | Mitochondria embedded in degalactosylated xyloglucan hydrogels to improve mitochondrial transplantation |
| title_full_unstemmed | Mitochondria embedded in degalactosylated xyloglucan hydrogels to improve mitochondrial transplantation |
| title_short | Mitochondria embedded in degalactosylated xyloglucan hydrogels to improve mitochondrial transplantation |
| title_sort | mitochondria embedded in degalactosylated xyloglucan hydrogels to improve mitochondrial transplantation |
| topic | Mitochondria Hydrogel delivery device Mitochondrial transplantation Degalactosylated xyloglucan Heart injection Hydrogel injection |
| url | http://www.sciencedirect.com/science/article/pii/S2666893924001233 |
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