Analysis of factors associated with intercostal neuralgia after osteoporotic thoracic spine fracture and construction of a prediction model
Abstract Objective This study aims to investigate the associated factors of intercostal neuralgia in patients with osteoporotic vertebral compression fractures (OVCF) of the thoracic spine and to develop a predictive model to assess the likelihood of patients developing intercostal neuralgia followi...
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BMC
2025-02-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-025-08358-9 |
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| author | Zhen-Gang Liu Fan Yang Peng-fu Li Qi Song Gao Wang Bo-Yin Zhang |
| author_facet | Zhen-Gang Liu Fan Yang Peng-fu Li Qi Song Gao Wang Bo-Yin Zhang |
| author_sort | Zhen-Gang Liu |
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| description | Abstract Objective This study aims to investigate the associated factors of intercostal neuralgia in patients with osteoporotic vertebral compression fractures (OVCF) of the thoracic spine and to develop a predictive model to assess the likelihood of patients developing intercostal neuralgia following thoracic vertebral fractures. Methods The retrospective study involved 518 patients with thoracic OVCF treated at our hospital, among whom those with and without intercostal neuralgia were matched at a 1:1 ratio.Relevant basic clinical data and imaging parameters of the patients were recorded, t-test was used for continuous variables and chi-square test for categorical variables to determine the factors associated with intercostal neuralgia. Subsequently, the above associated variables were screened using univariate and multivariate logistic regression models to obtain associated factors. Finally, a prediction model for osteoporotic thoracic spine fracture was developed and validated. Results This study included a total of 104 patients based on the presence or absence of intercostal neuralgia.The results of multifactorial logistic regression analysis showed that injured vertebral intervertebral foraminal area (P = 0.0008, regression coefficient estimate 0.0490, 95% confidence interval 0.0219–0.0798, OR = 1.0503), injured vertebral intervertebral foraminal volume (P = 0.0001, regression coefficient value − 0.0028, 95% confidence interval − 0.0044 to -0.0015, OR = 0.9972), and nerve root area (P = 0.0038, regression coefficient estimate=-0.0876, 95% confidence interval − 0.1506 to -0.0309, OR = 0.9161) were independent associated factors.The fatty degeneration ratio have a positive promotional effect on the probability of developing intercostal pain.The area under the ROC curve (AUC) of the prediction model was 0.851, which indicated that the line graph model had a certain degree of predictive validity. Conclusion Thoracic osteoporotic fractures are a common geriatric disease, and changes in the morphological parameters of the intervertebral foramina, such as a reduction in the area and volume of the injured vertebral intervertebral foramina, as well as fatty degeneration of the thoracic back muscles, suggest an increased probability of developing intercostal neuralgia. |
| format | Article |
| id | doaj-art-e44fe101db9546dfaba42bd515e1c57f |
| institution | Kabale University |
| issn | 1471-2474 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-e44fe101db9546dfaba42bd515e1c57f2025-02-09T12:04:11ZengBMCBMC Musculoskeletal Disorders1471-24742025-02-0126111410.1186/s12891-025-08358-9Analysis of factors associated with intercostal neuralgia after osteoporotic thoracic spine fracture and construction of a prediction modelZhen-Gang Liu0Fan Yang1Peng-fu Li2Qi Song3Gao Wang4Bo-Yin Zhang5Department of Orthopaedics, China-Japan Union Hospital of Jilin UniversityDepartment of Orthopaedics, China-Japan Union Hospital of Jilin UniversityDepartment of Orthopaedics, China-Japan Union Hospital of Jilin UniversityDepartment of Orthopaedics, China-Japan Union Hospital of Jilin UniversityDepartment of Orthopaedics, China-Japan Union Hospital of Jilin UniversityDepartment of Orthopaedics, China-Japan Union Hospital of Jilin UniversityAbstract Objective This study aims to investigate the associated factors of intercostal neuralgia in patients with osteoporotic vertebral compression fractures (OVCF) of the thoracic spine and to develop a predictive model to assess the likelihood of patients developing intercostal neuralgia following thoracic vertebral fractures. Methods The retrospective study involved 518 patients with thoracic OVCF treated at our hospital, among whom those with and without intercostal neuralgia were matched at a 1:1 ratio.Relevant basic clinical data and imaging parameters of the patients were recorded, t-test was used for continuous variables and chi-square test for categorical variables to determine the factors associated with intercostal neuralgia. Subsequently, the above associated variables were screened using univariate and multivariate logistic regression models to obtain associated factors. Finally, a prediction model for osteoporotic thoracic spine fracture was developed and validated. Results This study included a total of 104 patients based on the presence or absence of intercostal neuralgia.The results of multifactorial logistic regression analysis showed that injured vertebral intervertebral foraminal area (P = 0.0008, regression coefficient estimate 0.0490, 95% confidence interval 0.0219–0.0798, OR = 1.0503), injured vertebral intervertebral foraminal volume (P = 0.0001, regression coefficient value − 0.0028, 95% confidence interval − 0.0044 to -0.0015, OR = 0.9972), and nerve root area (P = 0.0038, regression coefficient estimate=-0.0876, 95% confidence interval − 0.1506 to -0.0309, OR = 0.9161) were independent associated factors.The fatty degeneration ratio have a positive promotional effect on the probability of developing intercostal pain.The area under the ROC curve (AUC) of the prediction model was 0.851, which indicated that the line graph model had a certain degree of predictive validity. Conclusion Thoracic osteoporotic fractures are a common geriatric disease, and changes in the morphological parameters of the intervertebral foramina, such as a reduction in the area and volume of the injured vertebral intervertebral foramina, as well as fatty degeneration of the thoracic back muscles, suggest an increased probability of developing intercostal neuralgia.https://doi.org/10.1186/s12891-025-08358-9Osteoporotic vertebral compression fractureIntercostal neuralgiaIntervertebral foraminaSarcopeniaNerve root |
| spellingShingle | Zhen-Gang Liu Fan Yang Peng-fu Li Qi Song Gao Wang Bo-Yin Zhang Analysis of factors associated with intercostal neuralgia after osteoporotic thoracic spine fracture and construction of a prediction model BMC Musculoskeletal Disorders Osteoporotic vertebral compression fracture Intercostal neuralgia Intervertebral foramina Sarcopenia Nerve root |
| title | Analysis of factors associated with intercostal neuralgia after osteoporotic thoracic spine fracture and construction of a prediction model |
| title_full | Analysis of factors associated with intercostal neuralgia after osteoporotic thoracic spine fracture and construction of a prediction model |
| title_fullStr | Analysis of factors associated with intercostal neuralgia after osteoporotic thoracic spine fracture and construction of a prediction model |
| title_full_unstemmed | Analysis of factors associated with intercostal neuralgia after osteoporotic thoracic spine fracture and construction of a prediction model |
| title_short | Analysis of factors associated with intercostal neuralgia after osteoporotic thoracic spine fracture and construction of a prediction model |
| title_sort | analysis of factors associated with intercostal neuralgia after osteoporotic thoracic spine fracture and construction of a prediction model |
| topic | Osteoporotic vertebral compression fracture Intercostal neuralgia Intervertebral foramina Sarcopenia Nerve root |
| url | https://doi.org/10.1186/s12891-025-08358-9 |
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