Development and validation of the quantification of GIZH-298, possessing in the rat blood plasma by HPLC-UF
He technique of quantitative determination of a new compound GIZH-298 in the rat blood plasma was developed and validated. Analysis was performed by HPLC-UV. The method was linear in the range of 100-5000 ng/ml. Recovery of GIZH-298 was 86,88 %. Limit of detection was 100 ng/ml.
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2019-02-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/93 |
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| author | O. G. Gribakina R. V. Shevchenko G. B. Kolyvanov A. A. Litvin P. O. Bochkov S. S. Boyko V. P. Zherdev |
| author_facet | O. G. Gribakina R. V. Shevchenko G. B. Kolyvanov A. A. Litvin P. O. Bochkov S. S. Boyko V. P. Zherdev |
| author_sort | O. G. Gribakina |
| collection | DOAJ |
| description | He technique of quantitative determination of a new compound GIZH-298 in the rat blood plasma was developed and validated. Analysis was performed by HPLC-UV. The method was linear in the range of 100-5000 ng/ml. Recovery of GIZH-298 was 86,88 %. Limit of detection was 100 ng/ml. |
| format | Article |
| id | doaj-art-e44f9f3c64d84451b942d108275d0e5a |
| institution | DOAJ |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2019-02-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-e44f9f3c64d84451b942d108275d0e5a2025-08-20T02:49:53ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302019-02-0102414510.24411/2587-7836-2019-1004692Development and validation of the quantification of GIZH-298, possessing in the rat blood plasma by HPLC-UFO. G. Gribakina0R. V. Shevchenko1G. B. Kolyvanov2A. A. Litvin3P. O. Bochkov4S. S. Boyko5V. P. Zherdev6FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»He technique of quantitative determination of a new compound GIZH-298 in the rat blood plasma was developed and validated. Analysis was performed by HPLC-UV. The method was linear in the range of 100-5000 ng/ml. Recovery of GIZH-298 was 86,88 %. Limit of detection was 100 ng/ml.https://www.pharmacokinetica.ru/jour/article/view/93гиж-298количественное определениевысокоэффективная жидкостная хроматографияплазма кровиgizh-298rat blood plasmahplc-uvquantification |
| spellingShingle | O. G. Gribakina R. V. Shevchenko G. B. Kolyvanov A. A. Litvin P. O. Bochkov S. S. Boyko V. P. Zherdev Development and validation of the quantification of GIZH-298, possessing in the rat blood plasma by HPLC-UF Фармакокинетика и Фармакодинамика гиж-298 количественное определение высокоэффективная жидкостная хроматография плазма крови gizh-298 rat blood plasma hplc-uv quantification |
| title | Development and validation of the quantification of GIZH-298, possessing in the rat blood plasma by HPLC-UF |
| title_full | Development and validation of the quantification of GIZH-298, possessing in the rat blood plasma by HPLC-UF |
| title_fullStr | Development and validation of the quantification of GIZH-298, possessing in the rat blood plasma by HPLC-UF |
| title_full_unstemmed | Development and validation of the quantification of GIZH-298, possessing in the rat blood plasma by HPLC-UF |
| title_short | Development and validation of the quantification of GIZH-298, possessing in the rat blood plasma by HPLC-UF |
| title_sort | development and validation of the quantification of gizh 298 possessing in the rat blood plasma by hplc uf |
| topic | гиж-298 количественное определение высокоэффективная жидкостная хроматография плазма крови gizh-298 rat blood plasma hplc-uv quantification |
| url | https://www.pharmacokinetica.ru/jour/article/view/93 |
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