Non-Injection Chemotherapy Regimens for Drug Resistant Tuberculosis in Children and Adolescents
The objective: to determine the effectiveness and safety (tolerability) of non-injection chemotherapy regimens containing bedaquiline in pediatric patients with multiple drug resistant respiratory tuberculosis.Subjects and Methods. Effectiveness and safety of treatment regimens containing non-inject...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2023-12-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1775 |
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| author | V. A. Aksenova N. I. Klevno A. V. Kazakov A. D. Pakhlavonova V. A. Romanenko N. Yu. Nikolenko |
| author_facet | V. A. Aksenova N. I. Klevno A. V. Kazakov A. D. Pakhlavonova V. A. Romanenko N. Yu. Nikolenko |
| author_sort | V. A. Aksenova |
| collection | DOAJ |
| description | The objective: to determine the effectiveness and safety (tolerability) of non-injection chemotherapy regimens containing bedaquiline in pediatric patients with multiple drug resistant respiratory tuberculosis.Subjects and Methods. Effectiveness and safety of treatment regimens containing non-injection drugs and Bdq were studied in 45 children from Main Group (MG) aged from 5 to 17 years old inclusive who were ill with multiple drug resistant tuberculosis. Control Group (CG) included patients of the same age with MDR TB who were treated with chemotherapy regimens containing injectable drugs (a retrospective study).Results. After 24 weeks (the period during which patients took bedaquiline), clinical effectiveness of chemotherapy regimens was achieved in all patients. By the end of week 24 of treatment, significant positive radiographic changes were noted in 84.4% of patients in MG and in 75.7% in CG (OR 1.741; 95% CI 0.658–4.611), healing of cavities was achieved in 42 (93.3%) and 66 (94.3%) patients, respectively (OR 0.848, 95% CI 0.181-3.982). No tuberculous mycobacteria were not detected in 100% of cases in both groups by month 6 of chemotherapy. The number of adverse reactions (AR) per patient averaged 1.25 and 1.26 in MG and CG. ARs occurred in patients receiving aminoglycosides in 41.4%: in MG – in 33.3%; 4/70 (5.7%) children from CG receiving injectable drugs developed adverse reactions requiring replacement of anti-tuberculosis drugs. No irreversible ARs were observed in MG. |
| format | Article |
| id | doaj-art-e44f8a6fe71247e9baffdd1fbf08f165 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2023-12-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-e44f8a6fe71247e9baffdd1fbf08f1652025-08-20T02:05:47ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062023-12-011016202710.58838/2075-1230-2023-101-6-20-271770Non-Injection Chemotherapy Regimens for Drug Resistant Tuberculosis in Children and AdolescentsV. A. Aksenova0N. I. Klevno1A. V. Kazakov2A. D. Pakhlavonova3V. A. Romanenko4N. Yu. Nikolenko5National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health; I. M. Sechenov First Moscow State Medical University (Sechenov University), Russian Ministry of HealthNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health; I. M. Sechenov First Moscow State Medical University (Sechenov University), Russian Ministry of HealthNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health; I. M. Sechenov First Moscow State Medical University (Sechenov University), Russian Ministry of HealthNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of HealthNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of HealthMoscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of HealthThe objective: to determine the effectiveness and safety (tolerability) of non-injection chemotherapy regimens containing bedaquiline in pediatric patients with multiple drug resistant respiratory tuberculosis.Subjects and Methods. Effectiveness and safety of treatment regimens containing non-injection drugs and Bdq were studied in 45 children from Main Group (MG) aged from 5 to 17 years old inclusive who were ill with multiple drug resistant tuberculosis. Control Group (CG) included patients of the same age with MDR TB who were treated with chemotherapy regimens containing injectable drugs (a retrospective study).Results. After 24 weeks (the period during which patients took bedaquiline), clinical effectiveness of chemotherapy regimens was achieved in all patients. By the end of week 24 of treatment, significant positive radiographic changes were noted in 84.4% of patients in MG and in 75.7% in CG (OR 1.741; 95% CI 0.658–4.611), healing of cavities was achieved in 42 (93.3%) and 66 (94.3%) patients, respectively (OR 0.848, 95% CI 0.181-3.982). No tuberculous mycobacteria were not detected in 100% of cases in both groups by month 6 of chemotherapy. The number of adverse reactions (AR) per patient averaged 1.25 and 1.26 in MG and CG. ARs occurred in patients receiving aminoglycosides in 41.4%: in MG – in 33.3%; 4/70 (5.7%) children from CG receiving injectable drugs developed adverse reactions requiring replacement of anti-tuberculosis drugs. No irreversible ARs were observed in MG.https://www.tibl-journal.com/jour/article/view/1775childrentuberculosismultiple drug resistant mycobacteriabedaquilineeffectiveness and safety of non-injection chemotherapy regimen |
| spellingShingle | V. A. Aksenova N. I. Klevno A. V. Kazakov A. D. Pakhlavonova V. A. Romanenko N. Yu. Nikolenko Non-Injection Chemotherapy Regimens for Drug Resistant Tuberculosis in Children and Adolescents Туберкулез и болезни лёгких children tuberculosis multiple drug resistant mycobacteria bedaquiline effectiveness and safety of non-injection chemotherapy regimen |
| title | Non-Injection Chemotherapy Regimens for Drug Resistant Tuberculosis in Children and Adolescents |
| title_full | Non-Injection Chemotherapy Regimens for Drug Resistant Tuberculosis in Children and Adolescents |
| title_fullStr | Non-Injection Chemotherapy Regimens for Drug Resistant Tuberculosis in Children and Adolescents |
| title_full_unstemmed | Non-Injection Chemotherapy Regimens for Drug Resistant Tuberculosis in Children and Adolescents |
| title_short | Non-Injection Chemotherapy Regimens for Drug Resistant Tuberculosis in Children and Adolescents |
| title_sort | non injection chemotherapy regimens for drug resistant tuberculosis in children and adolescents |
| topic | children tuberculosis multiple drug resistant mycobacteria bedaquiline effectiveness and safety of non-injection chemotherapy regimen |
| url | https://www.tibl-journal.com/jour/article/view/1775 |
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