NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors

NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors

Abstract The potential role of hydrogen sulfide (H2S) in the modulation of neuropathic pain is increasingly recognized. This study investigated the therapeutic effect of intraperitoneal injection of the H2S donor sodium hydrosulfide (NaHS) on neuropathic pain. Utilizing the spared nerve injury (SNI)...

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Bibliographic Details
Main Authors: Man-Man Qi, Heng-Yue Peng, Tian-Ge Zhang, Yan Li, Meng-Ya Gao, Wen-Bo Sun, Xu-Peng Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Sodium hydrosulfide
Neuropathic pain
Astrocytes
EAAT2
Online Access:https://doi.org/10.1038/s41598-025-86885-0
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