Measuring bone metabolic activity in dialysis patients with renal osteodystrophy using [18F]-Sodium Fluoride positron emission tomography- comparison between static and dynamic measurements
Abstract Background Dynamic [18F]NaF PET has shown promising results in the measurement of bone metabolism in patients with renal osteodystrophy. Dynamic PET scans are challenging in clinical practice, and the objective of this study was to evaluate whether standardized uptake values measured by [18...
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2025-04-01
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| Online Access: | https://doi.org/10.1186/s12882-025-04063-w |
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| author | Louise Aaltonen Niina Koivuviita Marko Seppänen Vesa Oikonen Anna K. Kirjavainen Heikki Kröger Eliisa Löyttyniemi Kaj Metsärinne |
| author_facet | Louise Aaltonen Niina Koivuviita Marko Seppänen Vesa Oikonen Anna K. Kirjavainen Heikki Kröger Eliisa Löyttyniemi Kaj Metsärinne |
| author_sort | Louise Aaltonen |
| collection | DOAJ |
| description | Abstract Background Dynamic [18F]NaF PET has shown promising results in the measurement of bone metabolism in patients with renal osteodystrophy. Dynamic PET scans are challenging in clinical practice, and the objective of this study was to evaluate whether standardized uptake values measured by [18F]NaF PET could be a feasible method. Methods Twenty-eight patients on maintenance dialysis with confirmed renal osteodystrophy underwent a dynamic [18F]NaF PET scan. As a reference for bone metabolism, a bone biopsy was obtained from the anterior iliac crest (AIC). Tracer activity in bone was measured using Patlak analysis and standardized uptake values (SUV). SUV was also adjusted to tracer activity measured from the aorta 48–60 min after injection (SUVR). Results SUV measured in the lumbar spine (L1-L4) and at the AIC did not correlate with histomorphometric parameters obtained by bone biopsy. There was no statistically significant difference between SUV in different turnover groups. When adjusting the mean bone uptake of fluoride in the lumbar spine, there was a strong correlation with the blood clearance of tracer to bone (Ki). SUVR also correlated significantly with histomorphometric markers obtained by bone biopsy. Conclusions These results suggest that measurements of tracer activity in the blood 48–60 min after tracer injection could be used to correct SUVs from static [18F]NaF PET scans. However, further research and validation of the method is needed. |
| format | Article |
| id | doaj-art-e447a313c63c4804bb14c7190b4889e1 |
| institution | DOAJ |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Nephrology |
| spelling | doaj-art-e447a313c63c4804bb14c7190b4889e12025-08-20T03:08:05ZengBMCBMC Nephrology1471-23692025-04-012611910.1186/s12882-025-04063-wMeasuring bone metabolic activity in dialysis patients with renal osteodystrophy using [18F]-Sodium Fluoride positron emission tomography- comparison between static and dynamic measurementsLouise Aaltonen0Niina Koivuviita1Marko Seppänen2Vesa Oikonen3Anna K. Kirjavainen4Heikki Kröger5Eliisa Löyttyniemi6Kaj Metsärinne7Kidney Center, Department of Medicine, Turku University HospitalKidney Center, Department of Medicine, Turku University HospitalTurku PET Centre, University of TurkuTurku PET Centre, University of TurkuRadiopharmaceutical Chemistry Laboratory, Turku PET Centre, University of TurkuKuopio University Hospital and University of Eastern FinlandDepartment of Biostatistics, University of TurkuKidney Center, Department of Medicine, Turku University HospitalAbstract Background Dynamic [18F]NaF PET has shown promising results in the measurement of bone metabolism in patients with renal osteodystrophy. Dynamic PET scans are challenging in clinical practice, and the objective of this study was to evaluate whether standardized uptake values measured by [18F]NaF PET could be a feasible method. Methods Twenty-eight patients on maintenance dialysis with confirmed renal osteodystrophy underwent a dynamic [18F]NaF PET scan. As a reference for bone metabolism, a bone biopsy was obtained from the anterior iliac crest (AIC). Tracer activity in bone was measured using Patlak analysis and standardized uptake values (SUV). SUV was also adjusted to tracer activity measured from the aorta 48–60 min after injection (SUVR). Results SUV measured in the lumbar spine (L1-L4) and at the AIC did not correlate with histomorphometric parameters obtained by bone biopsy. There was no statistically significant difference between SUV in different turnover groups. When adjusting the mean bone uptake of fluoride in the lumbar spine, there was a strong correlation with the blood clearance of tracer to bone (Ki). SUVR also correlated significantly with histomorphometric markers obtained by bone biopsy. Conclusions These results suggest that measurements of tracer activity in the blood 48–60 min after tracer injection could be used to correct SUVs from static [18F]NaF PET scans. However, further research and validation of the method is needed.https://doi.org/10.1186/s12882-025-04063-w[18F]NaF PET[18F]-sodium fluoride positron emission tomographyDynamicStaticBone histomorphometryRenal osteodystrophy |
| spellingShingle | Louise Aaltonen Niina Koivuviita Marko Seppänen Vesa Oikonen Anna K. Kirjavainen Heikki Kröger Eliisa Löyttyniemi Kaj Metsärinne Measuring bone metabolic activity in dialysis patients with renal osteodystrophy using [18F]-Sodium Fluoride positron emission tomography- comparison between static and dynamic measurements BMC Nephrology [18F]NaF PET [18F]-sodium fluoride positron emission tomography Dynamic Static Bone histomorphometry Renal osteodystrophy |
| title | Measuring bone metabolic activity in dialysis patients with renal osteodystrophy using [18F]-Sodium Fluoride positron emission tomography- comparison between static and dynamic measurements |
| title_full | Measuring bone metabolic activity in dialysis patients with renal osteodystrophy using [18F]-Sodium Fluoride positron emission tomography- comparison between static and dynamic measurements |
| title_fullStr | Measuring bone metabolic activity in dialysis patients with renal osteodystrophy using [18F]-Sodium Fluoride positron emission tomography- comparison between static and dynamic measurements |
| title_full_unstemmed | Measuring bone metabolic activity in dialysis patients with renal osteodystrophy using [18F]-Sodium Fluoride positron emission tomography- comparison between static and dynamic measurements |
| title_short | Measuring bone metabolic activity in dialysis patients with renal osteodystrophy using [18F]-Sodium Fluoride positron emission tomography- comparison between static and dynamic measurements |
| title_sort | measuring bone metabolic activity in dialysis patients with renal osteodystrophy using 18f sodium fluoride positron emission tomography comparison between static and dynamic measurements |
| topic | [18F]NaF PET [18F]-sodium fluoride positron emission tomography Dynamic Static Bone histomorphometry Renal osteodystrophy |
| url | https://doi.org/10.1186/s12882-025-04063-w |
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