Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells
T cell activation is invariably associated with virus infections, but activation of T cells is also noted, for example, in patients with persistent bacterial infections with intracellular pathogens or localised bacterial biofilms. The latter is characterised by a destructive inflammatory process. M...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.4061/2010/526740 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850166090127114240 |
|---|---|
| author | Dimitra Kotsougiani Marco Pioch Birgit Prior Volkmar Heppert G. Maria Hänsch Christof Wagner |
| author_facet | Dimitra Kotsougiani Marco Pioch Birgit Prior Volkmar Heppert G. Maria Hänsch Christof Wagner |
| author_sort | Dimitra Kotsougiani |
| collection | DOAJ |
| description | T cell activation is invariably associated with virus infections, but activation of T cells is also noted, for example, in patients with persistent bacterial infections with intracellular pathogens or localised bacterial biofilms. The latter is characterised by a destructive inflammatory process. Massive infiltration of leukocytes, predominantly of polymorphonuclear neutrophils (PMNs) and of T lymphocytes, is seen. While PMN influx into sites of bacterial infection is in line with their role as “first-line defence” a role of T cells in bacterial infection has not yet been delineated. We now found evidence for activation and expansion of peripheral blood T cells and an upregulation of Toll-like receptors 1, 2, and 4 on small portions of T cells. T cells recovered from the infected site were terminally differentiated and produced interferon gamma, a cytokine known to enhance functions of phagocytic cells, leading to the conclusion that infiltrated T cells support the local immuner defence. |
| format | Article |
| id | doaj-art-e4477f01c9fc43059fd27ef8dca8de1f |
| institution | OA Journals |
| issn | 2042-0099 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-e4477f01c9fc43059fd27ef8dca8de1f2025-08-20T02:21:34ZengWileyInternational Journal of Inflammation2042-00992010-01-01201010.4061/2010/526740526740Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T CellsDimitra Kotsougiani0Marco Pioch1Birgit Prior2Volkmar Heppert3G. Maria Hänsch4Christof Wagner5Institut für Immunologie, Universität Heidelberg, 69120 Heidelberg, GermanyKlinik für Unfallchirurgie und Orthopädie, Berufsgenossenschaftliche Unfallklinik, 67071 Ludwigshafen, GermanyInstitut für Immunologie, Universität Heidelberg, 69120 Heidelberg, GermanyAbteilung für Septische Chirurgie, Knochen-, Gelenk- und Protheseninfektionen, Berufsgenossenschaftliche Unfallklinik, 67071 Ludwigshafen, GermanyInstitut für Immunologie, Universität Heidelberg, 69120 Heidelberg, GermanyKlinik für Unfallchirurgie und Orthopädie, Berufsgenossenschaftliche Unfallklinik, 67071 Ludwigshafen, GermanyT cell activation is invariably associated with virus infections, but activation of T cells is also noted, for example, in patients with persistent bacterial infections with intracellular pathogens or localised bacterial biofilms. The latter is characterised by a destructive inflammatory process. Massive infiltration of leukocytes, predominantly of polymorphonuclear neutrophils (PMNs) and of T lymphocytes, is seen. While PMN influx into sites of bacterial infection is in line with their role as “first-line defence” a role of T cells in bacterial infection has not yet been delineated. We now found evidence for activation and expansion of peripheral blood T cells and an upregulation of Toll-like receptors 1, 2, and 4 on small portions of T cells. T cells recovered from the infected site were terminally differentiated and produced interferon gamma, a cytokine known to enhance functions of phagocytic cells, leading to the conclusion that infiltrated T cells support the local immuner defence.http://dx.doi.org/10.4061/2010/526740 |
| spellingShingle | Dimitra Kotsougiani Marco Pioch Birgit Prior Volkmar Heppert G. Maria Hänsch Christof Wagner Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells International Journal of Inflammation |
| title | Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells |
| title_full | Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells |
| title_fullStr | Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells |
| title_full_unstemmed | Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells |
| title_short | Activation of T Lymphocytes in Response to Persistent Bacterial Infection: Induction of CD11b and of Toll-Like Receptors on T Cells |
| title_sort | activation of t lymphocytes in response to persistent bacterial infection induction of cd11b and of toll like receptors on t cells |
| url | http://dx.doi.org/10.4061/2010/526740 |
| work_keys_str_mv | AT dimitrakotsougiani activationoftlymphocytesinresponsetopersistentbacterialinfectioninductionofcd11bandoftolllikereceptorsontcells AT marcopioch activationoftlymphocytesinresponsetopersistentbacterialinfectioninductionofcd11bandoftolllikereceptorsontcells AT birgitprior activationoftlymphocytesinresponsetopersistentbacterialinfectioninductionofcd11bandoftolllikereceptorsontcells AT volkmarheppert activationoftlymphocytesinresponsetopersistentbacterialinfectioninductionofcd11bandoftolllikereceptorsontcells AT gmariahansch activationoftlymphocytesinresponsetopersistentbacterialinfectioninductionofcd11bandoftolllikereceptorsontcells AT christofwagner activationoftlymphocytesinresponsetopersistentbacterialinfectioninductionofcd11bandoftolllikereceptorsontcells |