Helicobacter pylori-negative Gastric Mucosa-associated Lymphoid Tissue Lymphoma
Approximately 90% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas are associated with Helicobacter pylori infection and 10% of gastric MALT lymphomas occur independent of H. pylori infection. The gene translocation t(11;18)(q21;q21) is frequently observed in cases presenting with H. py...
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| Format: | Article |
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Korean College of Helicobacter and Upper Gastrointestinal Research
2017-09-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
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| Online Access: | http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2017.17.3.122 |
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| author | Jin Tae Jung |
| author_facet | Jin Tae Jung |
| author_sort | Jin Tae Jung |
| collection | DOAJ |
| description | Approximately 90% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas are associated with Helicobacter pylori infection and 10% of gastric MALT lymphomas occur independent of H. pylori infection. The gene translocation t(11;18)(q21;q21) is frequently observed in cases presenting with H. pylori-negative gastric MALT lymphomas. H. pylori-negative gastric MALT lymphomas do not differ from H. pylori-positive gastric MALT lymphomas in terms of clinical features and endoscopic findings and show similar prognosis. H. pylori eradication therapy could be considered as first-line treatment for gastric MALT lymphomas regardless of their H. pylori infection status. In cases with H. pylori-negative gastric MALT lymphomas, the rate of response to eradication therapy varies from 0 to 83%. If gastric MALT lymphoma persists for more than a year, secondary treatment with radiotherapy, chemotherapy, and/or surgery should be considered. Of note, the comparative outcome is excellent. |
| format | Article |
| id | doaj-art-e43ddfd14d874072af8594ff75fd8e19 |
| institution | Kabale University |
| issn | 1738-3331 |
| language | English |
| publishDate | 2017-09-01 |
| publisher | Korean College of Helicobacter and Upper Gastrointestinal Research |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj-art-e43ddfd14d874072af8594ff75fd8e192025-08-20T03:39:26ZengKorean College of Helicobacter and Upper Gastrointestinal ResearchThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312017-09-0117312212610.7704/kjhugr.2017.17.3.122kjhugr.2017.17.3.122Helicobacter pylori-negative Gastric Mucosa-associated Lymphoid Tissue LymphomaJin Tae Jung0Department of Internal medicine, Catholic University of Daegu School of Medicine, Daegu, KoreaApproximately 90% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas are associated with Helicobacter pylori infection and 10% of gastric MALT lymphomas occur independent of H. pylori infection. The gene translocation t(11;18)(q21;q21) is frequently observed in cases presenting with H. pylori-negative gastric MALT lymphomas. H. pylori-negative gastric MALT lymphomas do not differ from H. pylori-positive gastric MALT lymphomas in terms of clinical features and endoscopic findings and show similar prognosis. H. pylori eradication therapy could be considered as first-line treatment for gastric MALT lymphomas regardless of their H. pylori infection status. In cases with H. pylori-negative gastric MALT lymphomas, the rate of response to eradication therapy varies from 0 to 83%. If gastric MALT lymphoma persists for more than a year, secondary treatment with radiotherapy, chemotherapy, and/or surgery should be considered. Of note, the comparative outcome is excellent.http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2017.17.3.122Helicobacter pyloriLymphoma, B-cell, marginal zone |
| spellingShingle | Jin Tae Jung Helicobacter pylori-negative Gastric Mucosa-associated Lymphoid Tissue Lymphoma The Korean Journal of Helicobacter and Upper Gastrointestinal Research Helicobacter pylori Lymphoma, B-cell, marginal zone |
| title | Helicobacter pylori-negative Gastric Mucosa-associated Lymphoid Tissue Lymphoma |
| title_full | Helicobacter pylori-negative Gastric Mucosa-associated Lymphoid Tissue Lymphoma |
| title_fullStr | Helicobacter pylori-negative Gastric Mucosa-associated Lymphoid Tissue Lymphoma |
| title_full_unstemmed | Helicobacter pylori-negative Gastric Mucosa-associated Lymphoid Tissue Lymphoma |
| title_short | Helicobacter pylori-negative Gastric Mucosa-associated Lymphoid Tissue Lymphoma |
| title_sort | helicobacter pylori negative gastric mucosa associated lymphoid tissue lymphoma |
| topic | Helicobacter pylori Lymphoma, B-cell, marginal zone |
| url | http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2017.17.3.122 |
| work_keys_str_mv | AT jintaejung helicobacterpylorinegativegastricmucosaassociatedlymphoidtissuelymphoma |