Prevention of Subclinical Hypocalcemia in Holsteins Fed an Anionic Diet and Treated With Two Calcium Boluses at the Time of Calving
ABSTRACT Background The incidence of subclinical hypocalcemia (iSCH) based on blood ionized calcium (iCa < 1.00 mmol/L) has not been investigated in Holsteins fed an anionic diet (AD) and non‐AD prepartum and treated or not treated with calcium bolus (CB) around the time of calving. Hypothesis An...
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Wiley
2025-05-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.70122 |
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| author | Kemal Aksoy Abdülkerim Deniz Mert Metin Mahmut Insel Aytaç Pekmezci |
| author_facet | Kemal Aksoy Abdülkerim Deniz Mert Metin Mahmut Insel Aytaç Pekmezci |
| author_sort | Kemal Aksoy |
| collection | DOAJ |
| description | ABSTRACT Background The incidence of subclinical hypocalcemia (iSCH) based on blood ionized calcium (iCa < 1.00 mmol/L) has not been investigated in Holsteins fed an anionic diet (AD) and non‐AD prepartum and treated or not treated with calcium bolus (CB) around the time of calving. Hypothesis Anionic diets supported with CB at 12 h after calving should increase iCa and reduce iSCH better than AD + non‐CB and non‐AD + CB. Animals One hundred Holsteins were allocated to 4 groups: Group 1 (AD + CB), group 2 (AD + non‐CB), group 3 (non‐AD + CB) and group 4 (non‐AD and non‐CB). Methods The animals were randomly selected according to calving order. The iCa and iSCH were analyzed at calving before CB application on postpartum days (PPD) 1, 3, and 10. Urine pH was analyzed at calving and PPD1. Results Urine pH (6.43 ± 0.26), iCa (0.90 ± 0.16 mmol/L) and iSCH (50%) were significantly different in the combined AD groups compared to the non‐AD groups at calving. Multiparous cows in combined AD groups had higher iCa and lower iSCH at calving. Group 1 had a higher iCa than groups 3 and 4. Group 2 had a higher iCa than Group 4 at PPD3. The iSCH of group 1 at PPD3 and 10 was lower than that of other groups. The iSCH decreased from 50% (PPD1) to 17% (PPD3) and 4% (PPD10) in group 1. Group 4 showed milk fever of 12%, 4%, and 4% at PPD1, 3, and 9, respectively. Conclusion Group 1 was the most appropriate protocol to increase iCa, reduce iSCH, and prevent milk fever. |
| format | Article |
| id | doaj-art-e43c185b19ba41cabff9415cdaf50508 |
| institution | OA Journals |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
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| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-e43c185b19ba41cabff9415cdaf505082025-08-20T02:34:06ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-05-01393n/an/a10.1111/jvim.70122Prevention of Subclinical Hypocalcemia in Holsteins Fed an Anionic Diet and Treated With Two Calcium Boluses at the Time of CalvingKemal Aksoy0Abdülkerim Deniz1Mert Metin2Mahmut Insel3Aytaç Pekmezci4Depertmant of Internal Medicine, Milas Muğla Sitki Kocman University Muğla TurkeyFree Researcher for Clinical Biochemistry, Nisbetiye Mah. Bakır Sok. Beşiktaş Istanbul TurkeyFaculty of Veterinary Medicine Milas, Depertmant of Biochemistry, Milas Muğla Sitki Kocman University Muğla TurkeyFree Researcher, Kahramandere Mah. Güzelbahçe İzmir TurkeyFaculty of Science, Kötekli Mugla Sitki Kocman University Muğla TurkeyABSTRACT Background The incidence of subclinical hypocalcemia (iSCH) based on blood ionized calcium (iCa < 1.00 mmol/L) has not been investigated in Holsteins fed an anionic diet (AD) and non‐AD prepartum and treated or not treated with calcium bolus (CB) around the time of calving. Hypothesis Anionic diets supported with CB at 12 h after calving should increase iCa and reduce iSCH better than AD + non‐CB and non‐AD + CB. Animals One hundred Holsteins were allocated to 4 groups: Group 1 (AD + CB), group 2 (AD + non‐CB), group 3 (non‐AD + CB) and group 4 (non‐AD and non‐CB). Methods The animals were randomly selected according to calving order. The iCa and iSCH were analyzed at calving before CB application on postpartum days (PPD) 1, 3, and 10. Urine pH was analyzed at calving and PPD1. Results Urine pH (6.43 ± 0.26), iCa (0.90 ± 0.16 mmol/L) and iSCH (50%) were significantly different in the combined AD groups compared to the non‐AD groups at calving. Multiparous cows in combined AD groups had higher iCa and lower iSCH at calving. Group 1 had a higher iCa than groups 3 and 4. Group 2 had a higher iCa than Group 4 at PPD3. The iSCH of group 1 at PPD3 and 10 was lower than that of other groups. The iSCH decreased from 50% (PPD1) to 17% (PPD3) and 4% (PPD10) in group 1. Group 4 showed milk fever of 12%, 4%, and 4% at PPD1, 3, and 9, respectively. Conclusion Group 1 was the most appropriate protocol to increase iCa, reduce iSCH, and prevent milk fever.https://doi.org/10.1111/jvim.70122dairy cattleionized calciummetabolic acidificationmilk fever |
| spellingShingle | Kemal Aksoy Abdülkerim Deniz Mert Metin Mahmut Insel Aytaç Pekmezci Prevention of Subclinical Hypocalcemia in Holsteins Fed an Anionic Diet and Treated With Two Calcium Boluses at the Time of Calving Journal of Veterinary Internal Medicine dairy cattle ionized calcium metabolic acidification milk fever |
| title | Prevention of Subclinical Hypocalcemia in Holsteins Fed an Anionic Diet and Treated With Two Calcium Boluses at the Time of Calving |
| title_full | Prevention of Subclinical Hypocalcemia in Holsteins Fed an Anionic Diet and Treated With Two Calcium Boluses at the Time of Calving |
| title_fullStr | Prevention of Subclinical Hypocalcemia in Holsteins Fed an Anionic Diet and Treated With Two Calcium Boluses at the Time of Calving |
| title_full_unstemmed | Prevention of Subclinical Hypocalcemia in Holsteins Fed an Anionic Diet and Treated With Two Calcium Boluses at the Time of Calving |
| title_short | Prevention of Subclinical Hypocalcemia in Holsteins Fed an Anionic Diet and Treated With Two Calcium Boluses at the Time of Calving |
| title_sort | prevention of subclinical hypocalcemia in holsteins fed an anionic diet and treated with two calcium boluses at the time of calving |
| topic | dairy cattle ionized calcium metabolic acidification milk fever |
| url | https://doi.org/10.1111/jvim.70122 |
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