Integrating manual annotation with deep transfer learning and radiomics for vertebral fracture analysis

Integrating manual annotation with deep transfer learning and radiomics for vertebral fracture analysis

Abstract Background Vertebral compression fractures (VCFs) are prevalent in the elderly, often caused by osteoporosis or trauma. Differentiating acute from chronic VCFs is vital for treatment planning, but MRI, the gold standard, is inaccessible for some. However, CT, a more accessible alternative,...

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Bibliographic Details
Main Authors: Jing Wang, Zhirui Dong, Huanxin He, Zhiyang Gao, Yukai Huang, Guangcheng Yuan, Libo Jiang, Mingdong Zhao
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Medical Imaging
Subjects:
Deep transfer learning
Vertebral compression
Automatic segmentation
Fractures
Radiomics
Online Access:https://doi.org/10.1186/s12880-025-01573-9
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Summary:Abstract Background Vertebral compression fractures (VCFs) are prevalent in the elderly, often caused by osteoporosis or trauma. Differentiating acute from chronic VCFs is vital for treatment planning, but MRI, the gold standard, is inaccessible for some. However, CT, a more accessible alternative, lacks precision. This study aimed to enhance CT’s diagnostic accuracy for VCFs using deep transfer learning (DTL) and radiomics. Methods We retrospectively analyzed 218 VCF patients scanned with CT and MRI within 3 days from Oct 2022 to Feb 2024. MRI categorized VCFs. 3D regions of interest (ROIs) from CT scans underwent feature extraction and DTL modeling. Receiver operating characteristic (ROC) analysis evaluated models, with the best fused with radiomic features via LASSO. AUCs compared via Delong test, and clinical utility assessed by decision curve analysis (DCA). Results Patients were split into training (175) and test (43) sets. Traditional radiomics with LR yielded AUCs of 0.973 (training) and 0.869 (test). Optimal DTL modeling improved to 0.992 (training) and 0.941 (test). Feature fusion further boosted AUCs to 1.000 (training) and 0.964 (test). DCA validated its clinical significance. Conclusion The feature fusion model enhances the differential diagnosis of acute and chronic VCFs, outperforming single-model approaches and offering a valuable decision-support tool for patients unable to undergo spinal MRI.
ISSN:1471-2342

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