An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models
Abstract Although vaccines are usually given intramuscularly, the intranasal delivery route may lead to better mucosal protection and limit the spread of respiratory virus while easing administration and improving vaccine acceptance. The challenge, however, is to achieve delivery across the selectiv...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-59353-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849314838671523840 |
|---|---|
| author | Aina Karen Anthi Anette Kolderup Eline Benno Vaage Malin Bern Sopisa Benjakul Elias Tjärnhage Fulgencio Ruso-Julve Kjell-Rune Jensen Heidrun Elisabeth Lode Marina Vaysburd Jeannette Nilsen Marie Leangen Herigstad Siri Aastedatter Sakya Lisa Tietze Diego Pilati Mari Nyquist-Andersen Mirjam Dürkoop Torleif Tollefsrud Gjølberg Linghang Peng Stian Foss Morten C. Moe Benjamin E. Low Michael V. Wiles David Nemazee Frode L. Jahnsen John Torgils Vaage Kenneth A. Howard Inger Sandlie Leo C. James Gunnveig Grødeland Fridtjof Lund-Johansen Jan Terje Andersen |
| author_facet | Aina Karen Anthi Anette Kolderup Eline Benno Vaage Malin Bern Sopisa Benjakul Elias Tjärnhage Fulgencio Ruso-Julve Kjell-Rune Jensen Heidrun Elisabeth Lode Marina Vaysburd Jeannette Nilsen Marie Leangen Herigstad Siri Aastedatter Sakya Lisa Tietze Diego Pilati Mari Nyquist-Andersen Mirjam Dürkoop Torleif Tollefsrud Gjølberg Linghang Peng Stian Foss Morten C. Moe Benjamin E. Low Michael V. Wiles David Nemazee Frode L. Jahnsen John Torgils Vaage Kenneth A. Howard Inger Sandlie Leo C. James Gunnveig Grødeland Fridtjof Lund-Johansen Jan Terje Andersen |
| author_sort | Aina Karen Anthi |
| collection | DOAJ |
| description | Abstract Although vaccines are usually given intramuscularly, the intranasal delivery route may lead to better mucosal protection and limit the spread of respiratory virus while easing administration and improving vaccine acceptance. The challenge, however, is to achieve delivery across the selective epithelial cell barrier. Here we report on a subunit vaccine platform, in which the antigen is genetically fused to albumin to facilitate FcRn-mediated transport across the mucosal barrier in the presence of adjuvant. Intranasal delivery in conventional and transgenic mouse models induces both systemic and mucosal antigen-specific antibody responses that protect against challenge with SARS-CoV-2 or influenza A. When benchmarked against an intramuscularly administered mRNA vaccine or an intranasally administered antigen fused to an alternative carrier of similar size, only the albumin-based intranasal vaccine yields robust mucosal IgA antibody responses. Our results thus suggest that this needle-free, albumin-based vaccine platform may be suited for vaccination against respiratory pathogens. |
| format | Article |
| id | doaj-art-e437d11e1d4647a9aee9aebc214d701f |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-e437d11e1d4647a9aee9aebc214d701f2025-08-20T03:52:19ZengNature PortfolioNature Communications2041-17232025-05-0116111610.1038/s41467-025-59353-6An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse modelsAina Karen Anthi0Anette Kolderup1Eline Benno Vaage2Malin Bern3Sopisa Benjakul4Elias Tjärnhage5Fulgencio Ruso-Julve6Kjell-Rune Jensen7Heidrun Elisabeth Lode8Marina Vaysburd9Jeannette Nilsen10Marie Leangen Herigstad11Siri Aastedatter Sakya12Lisa Tietze13Diego Pilati14Mari Nyquist-Andersen15Mirjam Dürkoop16Torleif Tollefsrud Gjølberg17Linghang Peng18Stian Foss19Morten C. Moe20Benjamin E. Low21Michael V. Wiles22David Nemazee23Frode L. Jahnsen24John Torgils Vaage25Kenneth A. Howard26Inger Sandlie27Leo C. James28Gunnveig Grødeland29Fridtjof Lund-Johansen30Jan Terje Andersen31Department of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletProtein and Nucleic Acid Chemistry Division, Medical Research Council, Laboratory of Molecular BiologyDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletInterdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics, Aarhus UniversityDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology and Microbiology, The Scripps Research InstituteDepartment of Immunology, Oslo University Hospital RikshospitaletCenter of Eye Research, Department of Ophthalmology, Oslo University Hospital Ullevål and University of OsloThe Jackson LaboratoryThe Jackson LaboratoryDepartment of Immunology and Microbiology, The Scripps Research InstituteInstitute of Clinical Medicine, University of OsloDepartment of Immunology, Oslo University Hospital RikshospitaletInterdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics, Aarhus UniversityDepartment of Biosciences, University of OsloProtein and Nucleic Acid Chemistry Division, Medical Research Council, Laboratory of Molecular BiologyDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletDepartment of Immunology, Oslo University Hospital RikshospitaletAbstract Although vaccines are usually given intramuscularly, the intranasal delivery route may lead to better mucosal protection and limit the spread of respiratory virus while easing administration and improving vaccine acceptance. The challenge, however, is to achieve delivery across the selective epithelial cell barrier. Here we report on a subunit vaccine platform, in which the antigen is genetically fused to albumin to facilitate FcRn-mediated transport across the mucosal barrier in the presence of adjuvant. Intranasal delivery in conventional and transgenic mouse models induces both systemic and mucosal antigen-specific antibody responses that protect against challenge with SARS-CoV-2 or influenza A. When benchmarked against an intramuscularly administered mRNA vaccine or an intranasally administered antigen fused to an alternative carrier of similar size, only the albumin-based intranasal vaccine yields robust mucosal IgA antibody responses. Our results thus suggest that this needle-free, albumin-based vaccine platform may be suited for vaccination against respiratory pathogens.https://doi.org/10.1038/s41467-025-59353-6 |
| spellingShingle | Aina Karen Anthi Anette Kolderup Eline Benno Vaage Malin Bern Sopisa Benjakul Elias Tjärnhage Fulgencio Ruso-Julve Kjell-Rune Jensen Heidrun Elisabeth Lode Marina Vaysburd Jeannette Nilsen Marie Leangen Herigstad Siri Aastedatter Sakya Lisa Tietze Diego Pilati Mari Nyquist-Andersen Mirjam Dürkoop Torleif Tollefsrud Gjølberg Linghang Peng Stian Foss Morten C. Moe Benjamin E. Low Michael V. Wiles David Nemazee Frode L. Jahnsen John Torgils Vaage Kenneth A. Howard Inger Sandlie Leo C. James Gunnveig Grødeland Fridtjof Lund-Johansen Jan Terje Andersen An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models Nature Communications |
| title | An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models |
| title_full | An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models |
| title_fullStr | An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models |
| title_full_unstemmed | An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models |
| title_short | An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models |
| title_sort | intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models |
| url | https://doi.org/10.1038/s41467-025-59353-6 |
| work_keys_str_mv | AT ainakarenanthi anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT anettekolderup anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT elinebennovaage anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT malinbern anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT sopisabenjakul anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT eliastjarnhage anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT fulgenciorusojulve anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT kjellrunejensen anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT heidrunelisabethlode anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT marinavaysburd anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT jeannettenilsen anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT marieleangenherigstad anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT siriaastedattersakya anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT lisatietze anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT diegopilati anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT marinyquistandersen anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT mirjamdurkoop anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT torleiftollefsrudgjølberg anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT linghangpeng anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT stianfoss anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT mortencmoe anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT benjaminelow anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT michaelvwiles anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT davidnemazee anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT frodeljahnsen anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT johntorgilsvaage anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT kennethahoward anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT ingersandlie anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT leocjames anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT gunnveiggrødeland anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT fridtjoflundjohansen anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT janterjeandersen anintranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT ainakarenanthi intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT anettekolderup intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT elinebennovaage intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT malinbern intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT sopisabenjakul intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT eliastjarnhage intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT fulgenciorusojulve intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT kjellrunejensen intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT heidrunelisabethlode intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT marinavaysburd intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT jeannettenilsen intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT marieleangenherigstad intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT siriaastedattersakya intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT lisatietze intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT diegopilati intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT marinyquistandersen intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT mirjamdurkoop intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT torleiftollefsrudgjølberg intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT linghangpeng intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT stianfoss intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT mortencmoe intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT benjaminelow intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT michaelvwiles intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT davidnemazee intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT frodeljahnsen intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT johntorgilsvaage intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT kennethahoward intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT ingersandlie intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT leocjames intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT gunnveiggrødeland intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT fridtjoflundjohansen intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels AT janterjeandersen intranasalsubunitvaccineinducesprotectivesystemicandmucosalantibodyimmunityagainstrespiratoryvirusesinmousemodels |