Influence of the Human Skin Tumor Type in Photodynamic Therapy Analysed by a Predictive Model
Photodynamic Therapy (PDT) modeling allows the prediction of the treatment results depending on the lesion properties, the photosensitizer distribution, or the optical source characteristics. We employ a predictive PDT model and apply it to different skin tumors. It takes into account optical radiat...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Photoenergy |
| Online Access: | http://dx.doi.org/10.1155/2012/759205 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850166084451172352 |
|---|---|
| author | I. Salas-García F. Fanjul-Vélez J. L. Arce-Diego |
| author_facet | I. Salas-García F. Fanjul-Vélez J. L. Arce-Diego |
| author_sort | I. Salas-García |
| collection | DOAJ |
| description | Photodynamic Therapy (PDT) modeling allows the prediction of the treatment results depending on the lesion properties, the photosensitizer distribution, or the optical source characteristics. We employ a predictive PDT model and apply it to different skin tumors. It takes into account optical radiation distribution, a nonhomogeneous topical photosensitizer spatial temporal distribution, and the time-dependent photochemical interaction. The predicted singlet oxygen molecular concentrations with varying optical irradiance are compared and could be directly related with the necrosis area. The results show a strong dependence on the particular lesion. This suggests the need to design optimal PDT treatment protocols adapted to the specific patient and lesion. |
| format | Article |
| id | doaj-art-e435156738894b2e94335583e15dd5c1 |
| institution | OA Journals |
| issn | 1110-662X 1687-529X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Photoenergy |
| spelling | doaj-art-e435156738894b2e94335583e15dd5c12025-08-20T02:21:34ZengWileyInternational Journal of Photoenergy1110-662X1687-529X2012-01-01201210.1155/2012/759205759205Influence of the Human Skin Tumor Type in Photodynamic Therapy Analysed by a Predictive ModelI. Salas-García0F. Fanjul-Vélez1J. L. Arce-Diego2Applied Optical Techniques Group, TEISA Department, University of Cantabria, Avenida de los Castros S/N, 39005 Santander, SpainApplied Optical Techniques Group, TEISA Department, University of Cantabria, Avenida de los Castros S/N, 39005 Santander, SpainApplied Optical Techniques Group, TEISA Department, University of Cantabria, Avenida de los Castros S/N, 39005 Santander, SpainPhotodynamic Therapy (PDT) modeling allows the prediction of the treatment results depending on the lesion properties, the photosensitizer distribution, or the optical source characteristics. We employ a predictive PDT model and apply it to different skin tumors. It takes into account optical radiation distribution, a nonhomogeneous topical photosensitizer spatial temporal distribution, and the time-dependent photochemical interaction. The predicted singlet oxygen molecular concentrations with varying optical irradiance are compared and could be directly related with the necrosis area. The results show a strong dependence on the particular lesion. This suggests the need to design optimal PDT treatment protocols adapted to the specific patient and lesion.http://dx.doi.org/10.1155/2012/759205 |
| spellingShingle | I. Salas-García F. Fanjul-Vélez J. L. Arce-Diego Influence of the Human Skin Tumor Type in Photodynamic Therapy Analysed by a Predictive Model International Journal of Photoenergy |
| title | Influence of the Human Skin Tumor Type in Photodynamic Therapy Analysed by a Predictive Model |
| title_full | Influence of the Human Skin Tumor Type in Photodynamic Therapy Analysed by a Predictive Model |
| title_fullStr | Influence of the Human Skin Tumor Type in Photodynamic Therapy Analysed by a Predictive Model |
| title_full_unstemmed | Influence of the Human Skin Tumor Type in Photodynamic Therapy Analysed by a Predictive Model |
| title_short | Influence of the Human Skin Tumor Type in Photodynamic Therapy Analysed by a Predictive Model |
| title_sort | influence of the human skin tumor type in photodynamic therapy analysed by a predictive model |
| url | http://dx.doi.org/10.1155/2012/759205 |
| work_keys_str_mv | AT isalasgarcia influenceofthehumanskintumortypeinphotodynamictherapyanalysedbyapredictivemodel AT ffanjulvelez influenceofthehumanskintumortypeinphotodynamictherapyanalysedbyapredictivemodel AT jlarcediego influenceofthehumanskintumortypeinphotodynamictherapyanalysedbyapredictivemodel |