Research progress on phosphodiesterase 4 inhibitors in the treatment of palmoplantar pustulosis
Palmoplantar pustulosis (PPP) is a chronic recurrent inflammatory skin disease. Existing therapeutic methods cannot meet the demand by patients. Phosphodiesterase-4 (PDE-4) is a key enzyme involved in the balance of immunocytes. It acts as a downstream mediator in the signaling pathways of a variety...
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| Format: | Article |
| Language: | zho |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2024-11-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
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| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2024.11.011 |
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| _version_ | 1850120565994553344 |
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| author | YAO Xinyi Gao Wenli LI Juan ZHANG Junling |
| author_facet | YAO Xinyi Gao Wenli LI Juan ZHANG Junling |
| author_sort | YAO Xinyi |
| collection | DOAJ |
| description | Palmoplantar pustulosis (PPP) is a chronic recurrent inflammatory skin disease. Existing therapeutic methods cannot meet the demand by patients. Phosphodiesterase-4 (PDE-4) is a key enzyme involved in the balance of immunocytes. It acts as a downstream mediator in the signaling pathways of a variety of cytokines which are associated with palmoplantar pustulosis and extensively regulate immune responses. Apremilast, as representative of the oral PDE-4 inhibitors, displays superior efficacy in clinical trials against palmoplantar pustulosis. Crisaborole has also been regulate to induce sustained improvement in skin lesions. This article reviews the research progress on PDE-4 inhibitors in treatment of palmoplantar pustulosis. |
| format | Article |
| id | doaj-art-e42bb3ba441e4599b5ec7258242282e9 |
| institution | OA Journals |
| issn | 1674-8468 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj-art-e42bb3ba441e4599b5ec7258242282e92025-08-20T02:35:19Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682024-11-01311178979410.3969/j.issn.1674-8468.2024.11.011Research progress on phosphodiesterase 4 inhibitors in the treatment of palmoplantar pustulosisYAO Xinyi0Gao Wenli1LI Juan2ZHANG Junling3Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaGraduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaGraduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaTianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, ChinaPalmoplantar pustulosis (PPP) is a chronic recurrent inflammatory skin disease. Existing therapeutic methods cannot meet the demand by patients. Phosphodiesterase-4 (PDE-4) is a key enzyme involved in the balance of immunocytes. It acts as a downstream mediator in the signaling pathways of a variety of cytokines which are associated with palmoplantar pustulosis and extensively regulate immune responses. Apremilast, as representative of the oral PDE-4 inhibitors, displays superior efficacy in clinical trials against palmoplantar pustulosis. Crisaborole has also been regulate to induce sustained improvement in skin lesions. This article reviews the research progress on PDE-4 inhibitors in treatment of palmoplantar pustulosis.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2024.11.011palmoplantar pustulosispde-4 inhibitorapremilastcrisaborole |
| spellingShingle | YAO Xinyi Gao Wenli LI Juan ZHANG Junling Research progress on phosphodiesterase 4 inhibitors in the treatment of palmoplantar pustulosis Pifu-xingbing zhenliaoxue zazhi palmoplantar pustulosis pde-4 inhibitor apremilast crisaborole |
| title | Research progress on phosphodiesterase 4 inhibitors in the treatment of palmoplantar pustulosis |
| title_full | Research progress on phosphodiesterase 4 inhibitors in the treatment of palmoplantar pustulosis |
| title_fullStr | Research progress on phosphodiesterase 4 inhibitors in the treatment of palmoplantar pustulosis |
| title_full_unstemmed | Research progress on phosphodiesterase 4 inhibitors in the treatment of palmoplantar pustulosis |
| title_short | Research progress on phosphodiesterase 4 inhibitors in the treatment of palmoplantar pustulosis |
| title_sort | research progress on phosphodiesterase 4 inhibitors in the treatment of palmoplantar pustulosis |
| topic | palmoplantar pustulosis pde-4 inhibitor apremilast crisaborole |
| url | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2024.11.011 |
| work_keys_str_mv | AT yaoxinyi researchprogressonphosphodiesterase4inhibitorsinthetreatmentofpalmoplantarpustulosis AT gaowenli researchprogressonphosphodiesterase4inhibitorsinthetreatmentofpalmoplantarpustulosis AT lijuan researchprogressonphosphodiesterase4inhibitorsinthetreatmentofpalmoplantarpustulosis AT zhangjunling researchprogressonphosphodiesterase4inhibitorsinthetreatmentofpalmoplantarpustulosis |