Toxicity of copper (II) metal complexes with amino acids ligands: A study of activity in Aedes aegypti larvae
Abstract The larval control of Aedes aegypti has been done mainly by insecticides, which cause resistance and environmental contamination and have a high-cost development and application. The need for alternative solutions to problems caused by synthetic insecticides has led to studies to find new,...
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Academia Brasileira de Ciências
2025-05-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| author | EDUARDO JOSÉ DE ARRUDA CÍCERA MARIA DA SILVA ALESSANDRA R. LIMA GLENDA B. PORZANI MONIZE M. DA SILVA CLÁUDIO T. DE CARVALHO ISAÍAS CABRINI MAGDA F. FERNANDES |
| author_facet | EDUARDO JOSÉ DE ARRUDA CÍCERA MARIA DA SILVA ALESSANDRA R. LIMA GLENDA B. PORZANI MONIZE M. DA SILVA CLÁUDIO T. DE CARVALHO ISAÍAS CABRINI MAGDA F. FERNANDES |
| author_sort | EDUARDO JOSÉ DE ARRUDA |
| collection | DOAJ |
| description | Abstract The larval control of Aedes aegypti has been done mainly by insecticides, which cause resistance and environmental contamination and have a high-cost development and application. The need for alternative solutions to problems caused by synthetic insecticides has led to studies to find new, active, and less toxic compounds, such as metallo-insecticides. In the present study, the toxic activity of Cu(II) - complexes with the amino acids tryptophan, histidine, methionine, and taurine in Ae. aegypti larvae were evaluated. The Cu(II) - histidine complex showed no toxicity. For the Cu(II) - tryptophan and Cu(II) - methionine complexes, the mortality percentages ranged from 3.16% to 46.55% and 5.46% to 12.42%, respectively. Cu(II) - taurine presented 100% mortality in 24 h at the lowest concentration tested (50 mg L-1, ppm). Considering the concentration range of 50 to 1000 mg L-1 and 24 h of exposure of the larvae to the metal complexes, the series of decreasing toxicity is Cu(II) - taurine > Cu(II) - tryptophan > Cu(II) - methionine > Cu(II) - histidine. From these studies, the Cu (II) - taurine complex can be a candidate to be used as an alternative and less toxic insecticide, low-cost for control of Ae.aegypti larvae. |
| format | Article |
| id | doaj-art-e42a33216a8d4dd09407340ff4ec72c2 |
| institution | OA Journals |
| issn | 1678-2690 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj-art-e42a33216a8d4dd09407340ff4ec72c22025-08-20T01:55:08ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902025-05-0197210.1590/0001-3765202520240842Toxicity of copper (II) metal complexes with amino acids ligands: A study of activity in Aedes aegypti larvaeEDUARDO JOSÉ DE ARRUDAhttps://orcid.org/0000-0002-9835-467XCÍCERA MARIA DA SILVAhttps://orcid.org/0000-0001-6986-4905ALESSANDRA R. LIMAhttps://orcid.org/0000-0001-5810-5137GLENDA B. PORZANIhttps://orcid.org/0000-0002-1487-7175MONIZE M. DA SILVAhttps://orcid.org/0000-0002-1317-6609CLÁUDIO T. DE CARVALHOhttps://orcid.org/0000-0002-8081-4287ISAÍAS CABRINIhttps://orcid.org/0000-0002-5995-2714MAGDA F. FERNANDEShttps://orcid.org/0000-0002-5008-1238Abstract The larval control of Aedes aegypti has been done mainly by insecticides, which cause resistance and environmental contamination and have a high-cost development and application. The need for alternative solutions to problems caused by synthetic insecticides has led to studies to find new, active, and less toxic compounds, such as metallo-insecticides. In the present study, the toxic activity of Cu(II) - complexes with the amino acids tryptophan, histidine, methionine, and taurine in Ae. aegypti larvae were evaluated. The Cu(II) - histidine complex showed no toxicity. For the Cu(II) - tryptophan and Cu(II) - methionine complexes, the mortality percentages ranged from 3.16% to 46.55% and 5.46% to 12.42%, respectively. Cu(II) - taurine presented 100% mortality in 24 h at the lowest concentration tested (50 mg L-1, ppm). Considering the concentration range of 50 to 1000 mg L-1 and 24 h of exposure of the larvae to the metal complexes, the series of decreasing toxicity is Cu(II) - taurine > Cu(II) - tryptophan > Cu(II) - methionine > Cu(II) - histidine. From these studies, the Cu (II) - taurine complex can be a candidate to be used as an alternative and less toxic insecticide, low-cost for control of Ae.aegypti larvae.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652025000200506&lng=en&tlng=enAlternative compoundsbioinsecticidecontrolmosquitoviral disease |
| spellingShingle | EDUARDO JOSÉ DE ARRUDA CÍCERA MARIA DA SILVA ALESSANDRA R. LIMA GLENDA B. PORZANI MONIZE M. DA SILVA CLÁUDIO T. DE CARVALHO ISAÍAS CABRINI MAGDA F. FERNANDES Toxicity of copper (II) metal complexes with amino acids ligands: A study of activity in Aedes aegypti larvae Anais da Academia Brasileira de Ciências Alternative compounds bioinsecticide control mosquito viral disease |
| title | Toxicity of copper (II) metal complexes with amino acids ligands: A study of activity in Aedes aegypti larvae |
| title_full | Toxicity of copper (II) metal complexes with amino acids ligands: A study of activity in Aedes aegypti larvae |
| title_fullStr | Toxicity of copper (II) metal complexes with amino acids ligands: A study of activity in Aedes aegypti larvae |
| title_full_unstemmed | Toxicity of copper (II) metal complexes with amino acids ligands: A study of activity in Aedes aegypti larvae |
| title_short | Toxicity of copper (II) metal complexes with amino acids ligands: A study of activity in Aedes aegypti larvae |
| title_sort | toxicity of copper ii metal complexes with amino acids ligands a study of activity in aedes aegypti larvae |
| topic | Alternative compounds bioinsecticide control mosquito viral disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652025000200506&lng=en&tlng=en |
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