Genetic susceptibility to Candida infections
Abstract Candida spp. are medically important fungi causing severe mucosal and life‐threatening invasive infections, especially in immunocompromised hosts. However, not all individuals at risk develop Candida infections, and it is believed that genetic variation plays an important role in host susce...
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| Format: | Article |
| Language: | English |
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Springer Nature
2013-04-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.1002/emmm.201201678 |
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| author | Sanne P. Smeekens Frank L. van de Veerdonk Bart Jan Kullberg Mihai G. Netea |
| author_facet | Sanne P. Smeekens Frank L. van de Veerdonk Bart Jan Kullberg Mihai G. Netea |
| author_sort | Sanne P. Smeekens |
| collection | DOAJ |
| description | Abstract Candida spp. are medically important fungi causing severe mucosal and life‐threatening invasive infections, especially in immunocompromised hosts. However, not all individuals at risk develop Candida infections, and it is believed that genetic variation plays an important role in host susceptibility. On the one hand, severe fungal infections are associated with monogenic primary immunodeficiencies such as defects in STAT1, STAT3 or CARD9, recently discovered as novel clinical entities. On the other hand, more common polymorphisms in genes of the immune system have also been associated with fungal infections such as recurrent vulvovaginal candidiasis and candidemia. The discovery of the genetic susceptibility to Candida infections can lead to a better understanding of the pathogenesis of the disease, as well as to the design of novel immunotherapeutic strategies. This review is part of the review series on host‐pathogen interactions. See more reviews from this series . |
| format | Article |
| id | doaj-art-e423cbe46cbe459f9a722309be218645 |
| institution | OA Journals |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2013-04-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-e423cbe46cbe459f9a722309be2186452025-08-20T02:18:28ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842013-04-015680581310.1002/emmm.201201678Genetic susceptibility to Candida infectionsSanne P. Smeekens0Frank L. van de Veerdonk1Bart Jan Kullberg2Mihai G. Netea3Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity (N4i)Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity (N4i)Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity (N4i)Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity (N4i)Abstract Candida spp. are medically important fungi causing severe mucosal and life‐threatening invasive infections, especially in immunocompromised hosts. However, not all individuals at risk develop Candida infections, and it is believed that genetic variation plays an important role in host susceptibility. On the one hand, severe fungal infections are associated with monogenic primary immunodeficiencies such as defects in STAT1, STAT3 or CARD9, recently discovered as novel clinical entities. On the other hand, more common polymorphisms in genes of the immune system have also been associated with fungal infections such as recurrent vulvovaginal candidiasis and candidemia. The discovery of the genetic susceptibility to Candida infections can lead to a better understanding of the pathogenesis of the disease, as well as to the design of novel immunotherapeutic strategies. This review is part of the review series on host‐pathogen interactions. See more reviews from this series .https://doi.org/10.1002/emmm.201201678Candida albicansprimary immunodeficienciesinterferon gammainterleukin‐17disease susceptibility |
| spellingShingle | Sanne P. Smeekens Frank L. van de Veerdonk Bart Jan Kullberg Mihai G. Netea Genetic susceptibility to Candida infections EMBO Molecular Medicine Candida albicans primary immunodeficiencies interferon gamma interleukin‐17 disease susceptibility |
| title | Genetic susceptibility to Candida infections |
| title_full | Genetic susceptibility to Candida infections |
| title_fullStr | Genetic susceptibility to Candida infections |
| title_full_unstemmed | Genetic susceptibility to Candida infections |
| title_short | Genetic susceptibility to Candida infections |
| title_sort | genetic susceptibility to candida infections |
| topic | Candida albicans primary immunodeficiencies interferon gamma interleukin‐17 disease susceptibility |
| url | https://doi.org/10.1002/emmm.201201678 |
| work_keys_str_mv | AT sannepsmeekens geneticsusceptibilitytocandidainfections AT franklvandeveerdonk geneticsusceptibilitytocandidainfections AT bartjankullberg geneticsusceptibilitytocandidainfections AT mihaignetea geneticsusceptibilitytocandidainfections |