Diabetes mellitus, metabolic syndrome, and sleep disorders: An underestimated relationship
Diabetes mellitus (DM) is the most prevalent endocrine disorder globally. DM is under-evaluated and less efficiently managed in terms of ruling out comorbid conditions associated with it and predisposing factors resulting in poor outcomes. Sleep disorders are more common than usually diagnosed due t...
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| Language: | English |
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Wolters Kluwer Medknow Publications
2024-05-01
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| Series: | Annals of Medical Science and Research |
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| Online Access: | https://journals.lww.com/10.4103/amsr.amsr_3_24 |
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| author | Shital Patil Sanidhaya Tak Abdul Wahab Mirza |
| author_facet | Shital Patil Sanidhaya Tak Abdul Wahab Mirza |
| author_sort | Shital Patil |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is the most prevalent endocrine disorder globally. DM is under-evaluated and less efficiently managed in terms of ruling out comorbid conditions associated with it and predisposing factors resulting in poor outcomes. Sleep disorders are more common than usually diagnosed due to less awareness in the community regarding the importance of timely diagnosis and the impact of interventions related to proper sleep hygiene and sleep structure. Obstructive sleep apnea (OSA) is independently associated with cardiovascular and cardiometabolic risk in several large epidemiological studies. OSA leads to several physiological disturbances, such as intermittent hypoxia, sleep fragmentation, and an increase in autonomic tone. Metabolic syndrome (MS) is an adverse outcome that is typically associated with obesity. It is a cluster of metabolic risk factors for type 2 DM (T2DM) and cardiovascular diseases (CVDs), including central obesity, hypertension, hyperglycemia, insulin resistance, and dyslipidemia. T2DM is often associated with OSA, and a bidirectional relationship may exist between the two diseases, mediated by both weight- and physiology-dependent mechanisms. OSA is highly associated with T2DM, and treatment of OSA may have a positive impact on the cardiometabolic profile. In this review, we have attempted to summarize the impact of sleep disorders on MS and DM, and vice versa, with special emphasis on newer medical options in the management of DM and cardiometabolic syndrome. |
| format | Article |
| id | doaj-art-e421f5c613464ee2b7a0b8657a347bcd |
| institution | Kabale University |
| issn | 2949-785X 2949-7868 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Medical Science and Research |
| spelling | doaj-art-e421f5c613464ee2b7a0b8657a347bcd2025-08-20T04:02:22ZengWolters Kluwer Medknow PublicationsAnnals of Medical Science and Research2949-785X2949-78682024-05-01329110110.4103/amsr.amsr_3_24Diabetes mellitus, metabolic syndrome, and sleep disorders: An underestimated relationshipShital PatilSanidhaya TakAbdul Wahab MirzaDiabetes mellitus (DM) is the most prevalent endocrine disorder globally. DM is under-evaluated and less efficiently managed in terms of ruling out comorbid conditions associated with it and predisposing factors resulting in poor outcomes. Sleep disorders are more common than usually diagnosed due to less awareness in the community regarding the importance of timely diagnosis and the impact of interventions related to proper sleep hygiene and sleep structure. Obstructive sleep apnea (OSA) is independently associated with cardiovascular and cardiometabolic risk in several large epidemiological studies. OSA leads to several physiological disturbances, such as intermittent hypoxia, sleep fragmentation, and an increase in autonomic tone. Metabolic syndrome (MS) is an adverse outcome that is typically associated with obesity. It is a cluster of metabolic risk factors for type 2 DM (T2DM) and cardiovascular diseases (CVDs), including central obesity, hypertension, hyperglycemia, insulin resistance, and dyslipidemia. T2DM is often associated with OSA, and a bidirectional relationship may exist between the two diseases, mediated by both weight- and physiology-dependent mechanisms. OSA is highly associated with T2DM, and treatment of OSA may have a positive impact on the cardiometabolic profile. In this review, we have attempted to summarize the impact of sleep disorders on MS and DM, and vice versa, with special emphasis on newer medical options in the management of DM and cardiometabolic syndrome.https://journals.lww.com/10.4103/amsr.amsr_3_24diabetes mellitusmetabolic syndromeosasleep disorderst2dm |
| spellingShingle | Shital Patil Sanidhaya Tak Abdul Wahab Mirza Diabetes mellitus, metabolic syndrome, and sleep disorders: An underestimated relationship Annals of Medical Science and Research diabetes mellitus metabolic syndrome osa sleep disorders t2dm |
| title | Diabetes mellitus, metabolic syndrome, and sleep disorders: An underestimated relationship |
| title_full | Diabetes mellitus, metabolic syndrome, and sleep disorders: An underestimated relationship |
| title_fullStr | Diabetes mellitus, metabolic syndrome, and sleep disorders: An underestimated relationship |
| title_full_unstemmed | Diabetes mellitus, metabolic syndrome, and sleep disorders: An underestimated relationship |
| title_short | Diabetes mellitus, metabolic syndrome, and sleep disorders: An underestimated relationship |
| title_sort | diabetes mellitus metabolic syndrome and sleep disorders an underestimated relationship |
| topic | diabetes mellitus metabolic syndrome osa sleep disorders t2dm |
| url | https://journals.lww.com/10.4103/amsr.amsr_3_24 |
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