Evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection: a retrospective review
Abstract Background Sinonasal inverted papillomas (IP) are benign tumours arising from the mucosal lining of the nasal cavity and paranasal sinuses with a high propensity for recurrence and malignant transformation. Advances in endoscopic surgery and improved radiologic navigation have increased the...
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| Format: | Article |
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SAGE Publishing
2023-04-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
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| Online Access: | https://doi.org/10.1186/s40463-023-00638-5 |
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| author | Sheila Yu Elysia Grose Daniel J. Lee Vincent Wu Mitchell Pellarin John M. Lee |
| author_facet | Sheila Yu Elysia Grose Daniel J. Lee Vincent Wu Mitchell Pellarin John M. Lee |
| author_sort | Sheila Yu |
| collection | DOAJ |
| description | Abstract Background Sinonasal inverted papillomas (IP) are benign tumours arising from the mucosal lining of the nasal cavity and paranasal sinuses with a high propensity for recurrence and malignant transformation. Advances in endoscopic surgery and improved radiologic navigation have increased the role of endoscopic surgical resection in the treatment of IPs. The current study aims to evaluate the rate of IP recurrence after endoscopic endonasal resection and to evaluate factors which impact recurrence. Methods This was a single-centre retrospective chart review of all patients who underwent endoscopic sinus surgery for management of IP between January 2009 and February 2022. Primary outcomes were the rate of IP recurrence and time to IP recurrence. Secondary outcome measures were patient and tumour factors that contributed to IP recurrence. Results Eighty-five patients were included. The mean age was 55.7 and 36.5% of patients were female. The mean follow-up time was 39.5 months. Of the 85 cases, 13 cases (15.3%) had recurrence of their IP and the median time to recurrence was 22.0 months. All recurrent tumours recurred at the attachment site of the primary tumour. The univariate analysis did not identify any significant demographic, clinical, or surgical predictors of IP recurrence. There were no significant changes in sinonasal symptoms at the time IP recurrence was detected. Conclusion Endoscopic endonasal resection of IPs represents an effective surgical approach, however, the relatively high rate of recurrence and lack of symptomatic changes at the time of recurrence necessitates long term follow up. Better delineation of risk factors for recurrence can help identify high-risk patients and inform postoperative follow up strategies. |
| format | Article |
| id | doaj-art-e4202f72434c451d9f5570b731258e24 |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-e4202f72434c451d9f5570b731258e242025-08-20T03:26:25ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162023-04-015211810.1186/s40463-023-00638-5Evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection: a retrospective reviewSheila Yu0Elysia Grose1Daniel J. Lee2Vincent Wu3Mitchell Pellarin4John M. Lee5Division of Rhinology, Department of Otolaryngology – Head and Neck Surgery, St. Michael’s Hospital, Unity Health Toronto, University of TorontoDivision of Rhinology, Department of Otolaryngology – Head and Neck Surgery, St. Michael’s Hospital, Unity Health Toronto, University of TorontoDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of PennsylvaniaDivision of Rhinology, Department of Otolaryngology – Head and Neck Surgery, St. Michael’s Hospital, Unity Health Toronto, University of TorontoFaculty of Health Sciences, McMaster UniversityDivision of Rhinology, Department of Otolaryngology – Head and Neck Surgery, St. Michael’s Hospital, Unity Health Toronto, University of TorontoAbstract Background Sinonasal inverted papillomas (IP) are benign tumours arising from the mucosal lining of the nasal cavity and paranasal sinuses with a high propensity for recurrence and malignant transformation. Advances in endoscopic surgery and improved radiologic navigation have increased the role of endoscopic surgical resection in the treatment of IPs. The current study aims to evaluate the rate of IP recurrence after endoscopic endonasal resection and to evaluate factors which impact recurrence. Methods This was a single-centre retrospective chart review of all patients who underwent endoscopic sinus surgery for management of IP between January 2009 and February 2022. Primary outcomes were the rate of IP recurrence and time to IP recurrence. Secondary outcome measures were patient and tumour factors that contributed to IP recurrence. Results Eighty-five patients were included. The mean age was 55.7 and 36.5% of patients were female. The mean follow-up time was 39.5 months. Of the 85 cases, 13 cases (15.3%) had recurrence of their IP and the median time to recurrence was 22.0 months. All recurrent tumours recurred at the attachment site of the primary tumour. The univariate analysis did not identify any significant demographic, clinical, or surgical predictors of IP recurrence. There were no significant changes in sinonasal symptoms at the time IP recurrence was detected. Conclusion Endoscopic endonasal resection of IPs represents an effective surgical approach, however, the relatively high rate of recurrence and lack of symptomatic changes at the time of recurrence necessitates long term follow up. Better delineation of risk factors for recurrence can help identify high-risk patients and inform postoperative follow up strategies.https://doi.org/10.1186/s40463-023-00638-5Inverted papillomaSinonasal tumourEndoscopic sinus surgeryRecurrenceSNOT-22 |
| spellingShingle | Sheila Yu Elysia Grose Daniel J. Lee Vincent Wu Mitchell Pellarin John M. Lee Evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection: a retrospective review Journal of Otolaryngology - Head and Neck Surgery Inverted papilloma Sinonasal tumour Endoscopic sinus surgery Recurrence SNOT-22 |
| title | Evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection: a retrospective review |
| title_full | Evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection: a retrospective review |
| title_fullStr | Evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection: a retrospective review |
| title_full_unstemmed | Evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection: a retrospective review |
| title_short | Evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection: a retrospective review |
| title_sort | evaluation of inverted papilloma recurrence rates and factors associated recurrence after endoscopic surgical resection a retrospective review |
| topic | Inverted papilloma Sinonasal tumour Endoscopic sinus surgery Recurrence SNOT-22 |
| url | https://doi.org/10.1186/s40463-023-00638-5 |
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