Chemically modified non-coding RNAs in cancer
Abstract Background Non-coding RNAs (ncRNAs) are transcribed RNA molecules that do not encode proteins but regulate diverse biological processes. Dysregulation of ncRNAs is implicated in cancer, where chemical modifications such as N6-methyladenosine (m6A), N4-acetylcytidine (ac4C), and glycosylatio...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-01-01
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| Series: | Expert Reviews in Molecular Medicine |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S1462399425100070/type/journal_article |
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| _version_ | 1849233078394814464 |
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| author | Lulu Yang Boyang Wang Zhaohui Gong |
| author_facet | Lulu Yang Boyang Wang Zhaohui Gong |
| author_sort | Lulu Yang |
| collection | DOAJ |
| description | Abstract
Background
Non-coding RNAs (ncRNAs) are transcribed RNA molecules that do not encode proteins but regulate diverse biological processes. Dysregulation of ncRNAs is implicated in cancer, where chemical modifications such as N6-methyladenosine (m6A), N4-acetylcytidine (ac4C), and glycosylation critically influence their function. However, these modifications, as precise regulators of ncRNA activity, have been less well-documented and understood in tumorigenesis and cancer progression.
Methods
This article systematically analyzes the roles of chemically modified ncRNAs – ribosomal RNA (rRNA), circular RNA (circRNA) and others – in cancer biology, synthesizingevidence from published studies on their mechanistic involvement in malignancy.
Results
We reveal how specific chemical modifications drive oncogenesis, impact cancer diagnosis, and affect therapeutic responses, while also exploring their prognostic potential. Furthermore, we highlight emerging connections between ncRNA epitranscriptomics and cancer.
Conclusions
This review provides novel insights into ncRNA epitranscriptomics as emerging biomarkers and intervention targets for precision oncology.
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| format | Article |
| id | doaj-art-e41c1e04afbc44ffa327001066e27aae |
| institution | Kabale University |
| issn | 1462-3994 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Expert Reviews in Molecular Medicine |
| spelling | doaj-art-e41c1e04afbc44ffa327001066e27aae2025-08-20T12:57:28ZengCambridge University PressExpert Reviews in Molecular Medicine1462-39942025-01-012710.1017/erm.2025.10007Chemically modified non-coding RNAs in cancerLulu Yang0Boyang Wang1Zhaohui Gong2https://orcid.org/0000-0002-5662-2752Department of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology, School of Basic Medical Sciences, Health Science Center, https://ror.org/03et85d35 Ningbo University , Ningbo, Zhejiang, ChinaDepartment of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology, School of Basic Medical Sciences, Health Science Center, https://ror.org/03et85d35 Ningbo University , Ningbo, Zhejiang, ChinaDepartment of Biochemistry and Molecular Biology and Zhejiang Key Laboratory of Pathophysiology, School of Basic Medical Sciences, Health Science Center, https://ror.org/03et85d35 Ningbo University , Ningbo, Zhejiang, China Department of Thoracic Surgery, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaAbstract Background Non-coding RNAs (ncRNAs) are transcribed RNA molecules that do not encode proteins but regulate diverse biological processes. Dysregulation of ncRNAs is implicated in cancer, where chemical modifications such as N6-methyladenosine (m6A), N4-acetylcytidine (ac4C), and glycosylation critically influence their function. However, these modifications, as precise regulators of ncRNA activity, have been less well-documented and understood in tumorigenesis and cancer progression. Methods This article systematically analyzes the roles of chemically modified ncRNAs – ribosomal RNA (rRNA), circular RNA (circRNA) and others – in cancer biology, synthesizingevidence from published studies on their mechanistic involvement in malignancy. Results We reveal how specific chemical modifications drive oncogenesis, impact cancer diagnosis, and affect therapeutic responses, while also exploring their prognostic potential. Furthermore, we highlight emerging connections between ncRNA epitranscriptomics and cancer. Conclusions This review provides novel insights into ncRNA epitranscriptomics as emerging biomarkers and intervention targets for precision oncology. https://www.cambridge.org/core/product/identifier/S1462399425100070/type/journal_articlecancerchemical modificationdiagnosisnon-coding RNAtherapy |
| spellingShingle | Lulu Yang Boyang Wang Zhaohui Gong Chemically modified non-coding RNAs in cancer Expert Reviews in Molecular Medicine cancer chemical modification diagnosis non-coding RNA therapy |
| title | Chemically modified non-coding RNAs in cancer |
| title_full | Chemically modified non-coding RNAs in cancer |
| title_fullStr | Chemically modified non-coding RNAs in cancer |
| title_full_unstemmed | Chemically modified non-coding RNAs in cancer |
| title_short | Chemically modified non-coding RNAs in cancer |
| title_sort | chemically modified non coding rnas in cancer |
| topic | cancer chemical modification diagnosis non-coding RNA therapy |
| url | https://www.cambridge.org/core/product/identifier/S1462399425100070/type/journal_article |
| work_keys_str_mv | AT luluyang chemicallymodifiednoncodingrnasincancer AT boyangwang chemicallymodifiednoncodingrnasincancer AT zhaohuigong chemicallymodifiednoncodingrnasincancer |