Uncommon but Important: Tertiary Center Experience with Rare Cases of Breast Hamartoma
<b>Background:</b> A breast hamartoma or fibroadenolipoma is a rare, benign mass consisting of disorganized mature breast tissue elements. Surgical excision is recommended if the lesion exhibits rapid progressive growth. However, incomplete excision may result in recurrence. The objectiv...
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2025-07-01
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| author | Mihaela Camelia Tîrnovanu Bogdan Florin Toma Elena Cojocaru Elena Țarcă Ștefan Dragoș Tîrnovanu Vlad Gabriel Tîrnovanu Cristian Mârțu Roxana Ana Covali Anca Irina Gradinariu Gabriela Ghiga Ludmila Lozneanu |
| author_facet | Mihaela Camelia Tîrnovanu Bogdan Florin Toma Elena Cojocaru Elena Țarcă Ștefan Dragoș Tîrnovanu Vlad Gabriel Tîrnovanu Cristian Mârțu Roxana Ana Covali Anca Irina Gradinariu Gabriela Ghiga Ludmila Lozneanu |
| author_sort | Mihaela Camelia Tîrnovanu |
| collection | DOAJ |
| description | <b>Background:</b> A breast hamartoma or fibroadenolipoma is a rare, benign mass consisting of disorganized mature breast tissue elements. Surgical excision is recommended if the lesion exhibits rapid progressive growth. However, incomplete excision may result in recurrence. The objective of this study is to provide comprehensive insights into the characteristics of breast hamartomas and to conduct a thorough investigation into their clinical presentation, diagnostic procedures, and management strategies. <b>Methods</b>: We report on 13 cases of breast hamartomas treated surgically between January 2018 and June 2023 at the Obstetrics and Gynecology Hospital “Cuza Vodă” in Iași. We analyzed their histological images and immunohistochemical evaluations. <b>Results</b>: The mean age of the patients was 33.35 years, ranging from 22 to 57 years. Clinically, all patients presented with a painless mass. The diagnosis was confirmed through ultrasound examination, which revealed that hamartomas appeared as well-circumscribed, oval, and heterogeneous in echotexture. The tumor sizes ranged from 1 to 17 cm, with an average size of 6.75 cm. Surgical treatment involved lumpectomy with the excision of a small portion of normal tissue surrounding the tumor. The histological variability of these tumors poses diagnostic challenges for pathologists, potentially leading to underdiagnosis. <b>Conclusions</b>: Most hamartomas exhibit characteristic features on ultrasound attributable to their fibrous, glandular, and adipose tissue composition. Accurate identification of hamartomas is crucial due to the potential for recurrence. Notably, none of the women in our study experienced recurrence during the follow-up period. |
| format | Article |
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| institution | DOAJ |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-07-01 |
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| series | Life |
| spelling | doaj-art-e41a29df59f441d0965837aab56d30f72025-08-20T02:45:46ZengMDPI AGLife2075-17292025-07-01157107610.3390/life15071076Uncommon but Important: Tertiary Center Experience with Rare Cases of Breast HamartomaMihaela Camelia Tîrnovanu0Bogdan Florin Toma1Elena Cojocaru2Elena Țarcă3Ștefan Dragoș Tîrnovanu4Vlad Gabriel Tîrnovanu5Cristian Mârțu6Roxana Ana Covali7Anca Irina Gradinariu8Gabriela Ghiga9Ludmila Lozneanu10Department of Mother and Child Medicine, “Grigore. T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Morphofunctional Sciences I, “Grigore. T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Morphofunctional Sciences I, “Grigore. T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Surgery II, “Grigore. T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Surgery II, “Grigore. T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaSt. Josef Hospital, 65189 Wiesbaden, GermanyENT Clinic Department, “Grigore. T. Popa” University of Medicine and Pharmacy Iasi, 700115 Iasi, RomaniaDepartment of Medical Bioscience, Faculty of Bioengineering, “Grigore. T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Oral and Maxillofacial Surgery, “Grigore. T. Popa” University of Medicine and Pharmacy, 16 University Street, 700511 Iasi, RomaniaDepartment of Mother and Child Medicine, “Grigore. T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Morphofunctional Sciences I, “Grigore. T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania<b>Background:</b> A breast hamartoma or fibroadenolipoma is a rare, benign mass consisting of disorganized mature breast tissue elements. Surgical excision is recommended if the lesion exhibits rapid progressive growth. However, incomplete excision may result in recurrence. The objective of this study is to provide comprehensive insights into the characteristics of breast hamartomas and to conduct a thorough investigation into their clinical presentation, diagnostic procedures, and management strategies. <b>Methods</b>: We report on 13 cases of breast hamartomas treated surgically between January 2018 and June 2023 at the Obstetrics and Gynecology Hospital “Cuza Vodă” in Iași. We analyzed their histological images and immunohistochemical evaluations. <b>Results</b>: The mean age of the patients was 33.35 years, ranging from 22 to 57 years. Clinically, all patients presented with a painless mass. The diagnosis was confirmed through ultrasound examination, which revealed that hamartomas appeared as well-circumscribed, oval, and heterogeneous in echotexture. The tumor sizes ranged from 1 to 17 cm, with an average size of 6.75 cm. Surgical treatment involved lumpectomy with the excision of a small portion of normal tissue surrounding the tumor. The histological variability of these tumors poses diagnostic challenges for pathologists, potentially leading to underdiagnosis. <b>Conclusions</b>: Most hamartomas exhibit characteristic features on ultrasound attributable to their fibrous, glandular, and adipose tissue composition. Accurate identification of hamartomas is crucial due to the potential for recurrence. Notably, none of the women in our study experienced recurrence during the follow-up period.https://www.mdpi.com/2075-1729/15/7/1076breasthamartomapathologyimaging |
| spellingShingle | Mihaela Camelia Tîrnovanu Bogdan Florin Toma Elena Cojocaru Elena Țarcă Ștefan Dragoș Tîrnovanu Vlad Gabriel Tîrnovanu Cristian Mârțu Roxana Ana Covali Anca Irina Gradinariu Gabriela Ghiga Ludmila Lozneanu Uncommon but Important: Tertiary Center Experience with Rare Cases of Breast Hamartoma Life breast hamartoma pathology imaging |
| title | Uncommon but Important: Tertiary Center Experience with Rare Cases of Breast Hamartoma |
| title_full | Uncommon but Important: Tertiary Center Experience with Rare Cases of Breast Hamartoma |
| title_fullStr | Uncommon but Important: Tertiary Center Experience with Rare Cases of Breast Hamartoma |
| title_full_unstemmed | Uncommon but Important: Tertiary Center Experience with Rare Cases of Breast Hamartoma |
| title_short | Uncommon but Important: Tertiary Center Experience with Rare Cases of Breast Hamartoma |
| title_sort | uncommon but important tertiary center experience with rare cases of breast hamartoma |
| topic | breast hamartoma pathology imaging |
| url | https://www.mdpi.com/2075-1729/15/7/1076 |
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