Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature
Renal involvement is underestimated as an extramuscular manifestation of dermatomyositis (DM). Here, we describe a 67-year-old woman with anti-glycyl-transfer ribonucleic acid synthetase (anti-EJ) antibody and anti-ribonucleoprotein antibody-positive DM complicated by systemic sclerosis, who develop...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2022/1233522 |
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| author | Syoko Tsubouchi Takahiro Mizuuchi Yusuke Yamamoto Daiki Fujimori Kayo Ishii Mayu Tago Eri Kato Hiroaki Mori Haeru Hayashi Koichiro Tahara Tetsuji Sawada |
| author_facet | Syoko Tsubouchi Takahiro Mizuuchi Yusuke Yamamoto Daiki Fujimori Kayo Ishii Mayu Tago Eri Kato Hiroaki Mori Haeru Hayashi Koichiro Tahara Tetsuji Sawada |
| author_sort | Syoko Tsubouchi |
| collection | DOAJ |
| description | Renal involvement is underestimated as an extramuscular manifestation of dermatomyositis (DM). Here, we describe a 67-year-old woman with anti-glycyl-transfer ribonucleic acid synthetase (anti-EJ) antibody and anti-ribonucleoprotein antibody-positive DM complicated by systemic sclerosis, who developed nephrotic syndrome concurrently with the exacerbation of DM, as indicated by incremental serum creatine kinase levels, high-intensity lesions on muscle magnetic resonance imaging, and active interstitial pneumonitis on chest computed tomography. Renal biopsy revealed the presence of immune-deposition in the glomerulus by immunofluorescence. To our knowledge, this is the first report describing the coexistence of anti-EJ antibody-positive DM and nephrotic syndrome. More reports of similar cases are warranted to substantiate the association. |
| format | Article |
| id | doaj-art-e418f763b2c6429ca2e1aea4955c3dc7 |
| institution | Kabale University |
| issn | 2090-6897 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-e418f763b2c6429ca2e1aea4955c3dc72025-02-03T01:23:34ZengWileyCase Reports in Rheumatology2090-68972022-01-01202210.1155/2022/1233522Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the LiteratureSyoko Tsubouchi0Takahiro Mizuuchi1Yusuke Yamamoto2Daiki Fujimori3Kayo Ishii4Mayu Tago5Eri Kato6Hiroaki Mori7Haeru Hayashi8Koichiro Tahara9Tetsuji Sawada10Department of RheumatologyDepartment of RheumatologyDepartment of RheumatologyDepartment of RheumatologyDepartment of RheumatologyDepartment of RheumatologyDepartment of RheumatologyDepartment of RheumatologyDepartment of RheumatologyDepartment of RheumatologyDepartment of RheumatologyRenal involvement is underestimated as an extramuscular manifestation of dermatomyositis (DM). Here, we describe a 67-year-old woman with anti-glycyl-transfer ribonucleic acid synthetase (anti-EJ) antibody and anti-ribonucleoprotein antibody-positive DM complicated by systemic sclerosis, who developed nephrotic syndrome concurrently with the exacerbation of DM, as indicated by incremental serum creatine kinase levels, high-intensity lesions on muscle magnetic resonance imaging, and active interstitial pneumonitis on chest computed tomography. Renal biopsy revealed the presence of immune-deposition in the glomerulus by immunofluorescence. To our knowledge, this is the first report describing the coexistence of anti-EJ antibody-positive DM and nephrotic syndrome. More reports of similar cases are warranted to substantiate the association.http://dx.doi.org/10.1155/2022/1233522 |
| spellingShingle | Syoko Tsubouchi Takahiro Mizuuchi Yusuke Yamamoto Daiki Fujimori Kayo Ishii Mayu Tago Eri Kato Hiroaki Mori Haeru Hayashi Koichiro Tahara Tetsuji Sawada Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature Case Reports in Rheumatology |
| title | Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature |
| title_full | Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature |
| title_fullStr | Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature |
| title_full_unstemmed | Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature |
| title_short | Nephrotic Syndrome as an Extramuscular Manifestation of Anti-EJ Antibody-Positive Dermatomyositis: A Case Report and Review of the Literature |
| title_sort | nephrotic syndrome as an extramuscular manifestation of anti ej antibody positive dermatomyositis a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2022/1233522 |
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