Connective Tissue Growth Factor in Normal and Pathological Processes
Modern concepts about the role of connective tissue growth factor in various physiological and pathological processes are described in the review. Connective tissue growth factor regulates a variety of cellular functions, including proliferation, migration, adhesion, differentiation and synthesis of...
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| Format: | Article |
| Language: | Russian |
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SINAPS LLC
2020-07-01
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| Series: | Архивъ внутренней медицины |
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| Online Access: | https://www.medarhive.ru/jour/article/view/1070 |
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| _version_ | 1849303275536384000 |
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| author | S. V. Topolyanskaya |
| author_facet | S. V. Topolyanskaya |
| author_sort | S. V. Topolyanskaya |
| collection | DOAJ |
| description | Modern concepts about the role of connective tissue growth factor in various physiological and pathological processes are described in the review. Connective tissue growth factor regulates a variety of cellular functions, including proliferation, migration, adhesion, differentiation and synthesis of extracellular matrix proteins in cells of different types. This factor is also involved in more complex biological processes of angiogenesis, chondrogenesis, wound healing, fibrosis and oncogenesis. Increased expression of connective tissue growth factor is observed in different cardiovascular and oncological diseases. Potential role of this growth factor in regulation of cellular senescence and aging processes is also discussed. |
| format | Article |
| id | doaj-art-e417eab649d241bd9afca30ce29df4d7 |
| institution | Kabale University |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| publishDate | 2020-07-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj-art-e417eab649d241bd9afca30ce29df4d72025-08-20T04:00:01ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642020-07-0110425426110.20514/2226-6704-2020-10-4-254-261798Connective Tissue Growth Factor in Normal and Pathological ProcessesS. V. Topolyanskaya0I.M. Sechenov First Moscow State Medical University (Sechenov University), RF Health Ministry, Hospital Therapy Department № 2Modern concepts about the role of connective tissue growth factor in various physiological and pathological processes are described in the review. Connective tissue growth factor regulates a variety of cellular functions, including proliferation, migration, adhesion, differentiation and synthesis of extracellular matrix proteins in cells of different types. This factor is also involved in more complex biological processes of angiogenesis, chondrogenesis, wound healing, fibrosis and oncogenesis. Increased expression of connective tissue growth factor is observed in different cardiovascular and oncological diseases. Potential role of this growth factor in regulation of cellular senescence and aging processes is also discussed.https://www.medarhive.ru/jour/article/view/1070connective tissue growth factorfibrosisnephrosclerosischondrogenesisosteogenesisaging |
| spellingShingle | S. V. Topolyanskaya Connective Tissue Growth Factor in Normal and Pathological Processes Архивъ внутренней медицины connective tissue growth factor fibrosis nephrosclerosis chondrogenesis osteogenesis aging |
| title | Connective Tissue Growth Factor in Normal and Pathological Processes |
| title_full | Connective Tissue Growth Factor in Normal and Pathological Processes |
| title_fullStr | Connective Tissue Growth Factor in Normal and Pathological Processes |
| title_full_unstemmed | Connective Tissue Growth Factor in Normal and Pathological Processes |
| title_short | Connective Tissue Growth Factor in Normal and Pathological Processes |
| title_sort | connective tissue growth factor in normal and pathological processes |
| topic | connective tissue growth factor fibrosis nephrosclerosis chondrogenesis osteogenesis aging |
| url | https://www.medarhive.ru/jour/article/view/1070 |
| work_keys_str_mv | AT svtopolyanskaya connectivetissuegrowthfactorinnormalandpathologicalprocesses |