Radioactivity and Space Range of Ultra-Low-Activity for in vivo Off-line PET Verification of Proton and Carbon Ion Beam—A Phantom Study
Purpose: The radioactivity induced by proton and heavy ion beam belongs to the ultra-low-activity (ULA). Therefore, the radioactivity and space range of commercial off-line positron emission tomography (PET) acquisition based on ULA should be evaluated accurately to guarantee the reliability of clin...
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2021.771017/full |
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| author | Fuquan Zhang Fuquan Zhang Fuquan Zhang Fuquan Zhang Junyu Zhang Junyu Zhang Junyu Zhang Junyu Zhang Yan Lu Yixiangzi Sheng Yun Sun Jiangang Zhang Jingyi Cheng Jingyi Cheng Jingyi Cheng Rong Zhou |
| author_facet | Fuquan Zhang Fuquan Zhang Fuquan Zhang Fuquan Zhang Junyu Zhang Junyu Zhang Junyu Zhang Junyu Zhang Yan Lu Yixiangzi Sheng Yun Sun Jiangang Zhang Jingyi Cheng Jingyi Cheng Jingyi Cheng Rong Zhou |
| author_sort | Fuquan Zhang |
| collection | DOAJ |
| description | Purpose: The radioactivity induced by proton and heavy ion beam belongs to the ultra-low-activity (ULA). Therefore, the radioactivity and space range of commercial off-line positron emission tomography (PET) acquisition based on ULA should be evaluated accurately to guarantee the reliability of clinical verification. The purpose of this study is to quantify the radioactivity and space range of off-line PET acquisition by simulating the ULA triggered by proton and heavy ion beam.Methods: PET equipment validation phantom and low activity 18F-FDG were used to simulate the ULA with radioactivity of 11.1–1480 Bq/mL. The radioactivity of ULA was evaluated by comparing the radioactivity in the images with the values calculated from the decay function with a radioactivity error tolerance of 5%. The space range of ULA was evaluated by comparing the width of the R50 analyzed activity distribution curve with the actual width of the container with a space range error tolerance of 4 mm.Results: When radioactivity of ULA was >148 Bq/mL, the radioactivity error was <5%. When radioactivity of ULA was >30 Bq/mL, the space range error was below 4 mm.Conclusions: Off-line PET can be used to quantify the radioactivity of proton and heavy ion beam when the ULA exceeds 148 Bq/mL, both in radioactivity and in space range. |
| format | Article |
| id | doaj-art-e4174a4847ab4a818bcd3fe601419008 |
| institution | OA Journals |
| issn | 2296-2565 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-e4174a4847ab4a818bcd3fe6014190082025-08-20T01:53:33ZengFrontiers Media S.A.Frontiers in Public Health2296-25652021-12-01910.3389/fpubh.2021.771017771017Radioactivity and Space Range of Ultra-Low-Activity for in vivo Off-line PET Verification of Proton and Carbon Ion Beam—A Phantom StudyFuquan Zhang0Fuquan Zhang1Fuquan Zhang2Fuquan Zhang3Junyu Zhang4Junyu Zhang5Junyu Zhang6Junyu Zhang7Yan Lu8Yixiangzi Sheng9Yun Sun10Jiangang Zhang11Jingyi Cheng12Jingyi Cheng13Jingyi Cheng14Rong Zhou15College of Physics, Sichuan University, Chengdu, ChinaShanghai Key Laboratory of Radiation Oncology, Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, ChinaShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, ChinaCollege of Physics, Sichuan University, Chengdu, ChinaShanghai Key Laboratory of Radiation Oncology, Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, ChinaShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, ChinaDepartment of Radiotherapy, Shanghai Proton and Heavy Ion Center (SPHIC), Shanghai, ChinaDepartment of Radiotherapy, Shanghai Proton and Heavy Ion Center (SPHIC), Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, ChinaShanghai Key Laboratory of Radiation Oncology, Shanghai, ChinaDepartment of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, ChinaShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, ChinaCollege of Physics, Sichuan University, Chengdu, ChinaPurpose: The radioactivity induced by proton and heavy ion beam belongs to the ultra-low-activity (ULA). Therefore, the radioactivity and space range of commercial off-line positron emission tomography (PET) acquisition based on ULA should be evaluated accurately to guarantee the reliability of clinical verification. The purpose of this study is to quantify the radioactivity and space range of off-line PET acquisition by simulating the ULA triggered by proton and heavy ion beam.Methods: PET equipment validation phantom and low activity 18F-FDG were used to simulate the ULA with radioactivity of 11.1–1480 Bq/mL. The radioactivity of ULA was evaluated by comparing the radioactivity in the images with the values calculated from the decay function with a radioactivity error tolerance of 5%. The space range of ULA was evaluated by comparing the width of the R50 analyzed activity distribution curve with the actual width of the container with a space range error tolerance of 4 mm.Results: When radioactivity of ULA was >148 Bq/mL, the radioactivity error was <5%. When radioactivity of ULA was >30 Bq/mL, the space range error was below 4 mm.Conclusions: Off-line PET can be used to quantify the radioactivity of proton and heavy ion beam when the ULA exceeds 148 Bq/mL, both in radioactivity and in space range.https://www.frontiersin.org/articles/10.3389/fpubh.2021.771017/fullultra-low activityoff-line PETproton therapybeam rangePET verification |
| spellingShingle | Fuquan Zhang Fuquan Zhang Fuquan Zhang Fuquan Zhang Junyu Zhang Junyu Zhang Junyu Zhang Junyu Zhang Yan Lu Yixiangzi Sheng Yun Sun Jiangang Zhang Jingyi Cheng Jingyi Cheng Jingyi Cheng Rong Zhou Radioactivity and Space Range of Ultra-Low-Activity for in vivo Off-line PET Verification of Proton and Carbon Ion Beam—A Phantom Study Frontiers in Public Health ultra-low activity off-line PET proton therapy beam range PET verification |
| title | Radioactivity and Space Range of Ultra-Low-Activity for in vivo Off-line PET Verification of Proton and Carbon Ion Beam—A Phantom Study |
| title_full | Radioactivity and Space Range of Ultra-Low-Activity for in vivo Off-line PET Verification of Proton and Carbon Ion Beam—A Phantom Study |
| title_fullStr | Radioactivity and Space Range of Ultra-Low-Activity for in vivo Off-line PET Verification of Proton and Carbon Ion Beam—A Phantom Study |
| title_full_unstemmed | Radioactivity and Space Range of Ultra-Low-Activity for in vivo Off-line PET Verification of Proton and Carbon Ion Beam—A Phantom Study |
| title_short | Radioactivity and Space Range of Ultra-Low-Activity for in vivo Off-line PET Verification of Proton and Carbon Ion Beam—A Phantom Study |
| title_sort | radioactivity and space range of ultra low activity for in vivo off line pet verification of proton and carbon ion beam a phantom study |
| topic | ultra-low activity off-line PET proton therapy beam range PET verification |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2021.771017/full |
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