Impact of pharmacological and non-pharmacological approaches on the sleep quality of MS patients: A systematic review
Background: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, recognized by various symptoms, like fatigue, pain, cognitive impairment, and mood disorders, which can impact sleep and cause sleep disorders. Objective: Due to the scattered nature of existing evidence and...
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Elsevier
2025-01-01
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| Series: | International Journal of Africa Nursing Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214139125000691 |
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| author | Soheila Shamsikhani Mohammad Reza Shamshiri Mohammadsadegh Kamran Mahsa Hosseini |
| author_facet | Soheila Shamsikhani Mohammad Reza Shamshiri Mohammadsadegh Kamran Mahsa Hosseini |
| author_sort | Soheila Shamsikhani |
| collection | DOAJ |
| description | Background: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, recognized by various symptoms, like fatigue, pain, cognitive impairment, and mood disorders, which can impact sleep and cause sleep disorders. Objective: Due to the scattered nature of existing evidence and the significant clinical impact of sleep disturbances among patients with MS, this systematic review seeks to comprehensively integrate current pharmacological and non-pharmacological treatment approaches while identifying prevailing knowledge gaps and outlining directions for future investigations. Methods: A systematic search was conducted in PubMed, Web of Science, and Scopus databases up to September 2024, following PRISMA guidelines. The research was guided by the question: “What therapeutic approaches are effective in improving sleep quality in MS patients?” The PICOS framework defined the inclusion criteria (P = MS patients, I = Any intervention, C = Compared to other interventions, O = Sleep quality, S = Randomized controlled trials). After removing duplicates, the remaining articles were screened based on predefined inclusion/exclusion criteria. A total of 24 full-text articles were evaluated, and 16 studies met the final inclusion criteria. Data were extracted on study characteristics, intervention details, and outcomes. The quality of included studies was assessed using the NIH quality assessment tool for controlled intervention studies. Results: Sixteen randomized controlled trials (RCTs) were included. This study confirms the efficacy of melatonin and CBT-I as primary interventions while highlighting the potential of relaxation and mindfulness-based approaches. All studies referenced in this article were of acceptable quality, demonstrating either good or fair quality standards. Conclusion: This review provides valuable insights into the management of sleep disturbances in individuals with MS. It confirms the efficacy of melatonin and CBT-I as primary interventions while highlighting the potential of relaxation and mindfulness-based approaches.While melatonin showed some benefits, other medications had limited or mixed effects. These findings underscore the need for methodological improvements and more targeted research. Addressing these gaps will help refine clinical practices, ensuring better sleep quality and overall well-being for individuals with MS. |
| format | Article |
| id | doaj-art-e41597b33a6444e6bd4259a92c0df492 |
| institution | Kabale University |
| issn | 2214-1391 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Africa Nursing Sciences |
| spelling | doaj-art-e41597b33a6444e6bd4259a92c0df4922025-08-20T05:06:49ZengElsevierInternational Journal of Africa Nursing Sciences2214-13912025-01-012310088210.1016/j.ijans.2025.100882Impact of pharmacological and non-pharmacological approaches on the sleep quality of MS patients: A systematic reviewSoheila Shamsikhani0Mohammad Reza Shamshiri1Mohammadsadegh Kamran2Mahsa Hosseini3Department of Nursing, Shazand School of Nursing, Arak University of Medical Sciences, Arak, IranDepartment of Nursing, Shazand School of Nursing, Arak University of Medical Sciences, Arak, IranStudent Research Committee, Fasa University of Medical Sciences, Fasa, Iran; USERN Office, Fasa University of Medical, Fasa, IranDepartment of Nursing, Shazand School of Nursing, Arak University of Medical Sciences, Arak, Iran; Corresponding author at: Department of Nursing, Shazand School of Nursing, Arak University of Medical Sciences, Arak, Iran.Background: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, recognized by various symptoms, like fatigue, pain, cognitive impairment, and mood disorders, which can impact sleep and cause sleep disorders. Objective: Due to the scattered nature of existing evidence and the significant clinical impact of sleep disturbances among patients with MS, this systematic review seeks to comprehensively integrate current pharmacological and non-pharmacological treatment approaches while identifying prevailing knowledge gaps and outlining directions for future investigations. Methods: A systematic search was conducted in PubMed, Web of Science, and Scopus databases up to September 2024, following PRISMA guidelines. The research was guided by the question: “What therapeutic approaches are effective in improving sleep quality in MS patients?” The PICOS framework defined the inclusion criteria (P = MS patients, I = Any intervention, C = Compared to other interventions, O = Sleep quality, S = Randomized controlled trials). After removing duplicates, the remaining articles were screened based on predefined inclusion/exclusion criteria. A total of 24 full-text articles were evaluated, and 16 studies met the final inclusion criteria. Data were extracted on study characteristics, intervention details, and outcomes. The quality of included studies was assessed using the NIH quality assessment tool for controlled intervention studies. Results: Sixteen randomized controlled trials (RCTs) were included. This study confirms the efficacy of melatonin and CBT-I as primary interventions while highlighting the potential of relaxation and mindfulness-based approaches. All studies referenced in this article were of acceptable quality, demonstrating either good or fair quality standards. Conclusion: This review provides valuable insights into the management of sleep disturbances in individuals with MS. It confirms the efficacy of melatonin and CBT-I as primary interventions while highlighting the potential of relaxation and mindfulness-based approaches.While melatonin showed some benefits, other medications had limited or mixed effects. These findings underscore the need for methodological improvements and more targeted research. Addressing these gaps will help refine clinical practices, ensuring better sleep quality and overall well-being for individuals with MS.http://www.sciencedirect.com/science/article/pii/S2214139125000691Sleep qualitySleepMultiple sclerosisPharmacological InterventionsNon-Pharmacological Interventions |
| spellingShingle | Soheila Shamsikhani Mohammad Reza Shamshiri Mohammadsadegh Kamran Mahsa Hosseini Impact of pharmacological and non-pharmacological approaches on the sleep quality of MS patients: A systematic review International Journal of Africa Nursing Sciences Sleep quality Sleep Multiple sclerosis Pharmacological Interventions Non-Pharmacological Interventions |
| title | Impact of pharmacological and non-pharmacological approaches on the sleep quality of MS patients: A systematic review |
| title_full | Impact of pharmacological and non-pharmacological approaches on the sleep quality of MS patients: A systematic review |
| title_fullStr | Impact of pharmacological and non-pharmacological approaches on the sleep quality of MS patients: A systematic review |
| title_full_unstemmed | Impact of pharmacological and non-pharmacological approaches on the sleep quality of MS patients: A systematic review |
| title_short | Impact of pharmacological and non-pharmacological approaches on the sleep quality of MS patients: A systematic review |
| title_sort | impact of pharmacological and non pharmacological approaches on the sleep quality of ms patients a systematic review |
| topic | Sleep quality Sleep Multiple sclerosis Pharmacological Interventions Non-Pharmacological Interventions |
| url | http://www.sciencedirect.com/science/article/pii/S2214139125000691 |
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