Immunohistochemical Profile of p62/SQSTM1/Sequestosome-1 in Human Low- and High-Grade Intracranial Meningiomas
Among autophagic-related proteins, p62/SQSTM1/Sequestosome-1 represents a relevant actor in cellular proliferation and neoplastic growth. Although, recently, p62 expression has been analyzed in different neurodegenerative and glial neoplastic diseases, no available information have been reported in...
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| Format: | Article |
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Wiley
2024-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2024/5573892 |
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| author | Antonio Ieni Cristina Pizzimenti Vincenzo Fiorentino Mariausilia Franchina Antonino Germanò Giovanni Raffa Maurizio Martini Guido Fadda Giovanni Tuccari |
| author_facet | Antonio Ieni Cristina Pizzimenti Vincenzo Fiorentino Mariausilia Franchina Antonino Germanò Giovanni Raffa Maurizio Martini Guido Fadda Giovanni Tuccari |
| author_sort | Antonio Ieni |
| collection | DOAJ |
| description | Among autophagic-related proteins, p62/SQSTM1/Sequestosome-1 represents a relevant actor in cellular proliferation and neoplastic growth. Although, recently, p62 expression has been analyzed in different neurodegenerative and glial neoplastic diseases, no available information have been reported in meningiomas, which have an high epidemiological relevance being the second most common category of intracranial tumors after gliomas. Generally meningiomas have a benign behavior, but their recurrence is not uncommon mainly when atypical or anaplastic varieties occur. However, intranuclear vacuoles have been ultrastructurally observed in meningiomas, and they were labelled by p62 antibodies. Therefore, in the present study, we have investigated p62 immunohistochemical pattern in a cohort of 133 cases representative of low- and high-grade meningiomas, to verify if p62 expression may be related to clinicopathological data, thus achieving a potential prognostic role. The p62 immunoexpression was frequently found in the nucleus and cytoplasm of neoplastic elements, and utilizing an intensity-distribution score, 55 (41.3%) cases were considered as high expressors while 78 (58.7%) cases were instead recorded as low expressors. Fifteen cases exhibited recurrences of the disease, 14 of which were codified as high expressors. Moreover, a direct relationship between p62 and Mib-1 immunoexpression as well as between p62 and neoplastic grade have been documented. Finally, we suggest that impaired autophagic flux with an increase in p62 expression may be involved in the activation of NRF2 also contributing in the development of recurrence in meningioma patients. |
| format | Article |
| id | doaj-art-e40b7ba29f474b0797d0e59675c9582b |
| institution | Kabale University |
| issn | 2210-7185 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-e40b7ba29f474b0797d0e59675c9582b2025-02-03T10:05:25ZengWileyAnalytical Cellular Pathology2210-71852024-01-01202410.1155/2024/5573892Immunohistochemical Profile of p62/SQSTM1/Sequestosome-1 in Human Low- and High-Grade Intracranial MeningiomasAntonio Ieni0Cristina Pizzimenti1Vincenzo Fiorentino2Mariausilia Franchina3Antonino Germanò4Giovanni Raffa5Maurizio Martini6Guido Fadda7Giovanni Tuccari8Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, NeurosurgeryDepartment of Human Pathology in Adult and Developmental Age “Gaetano Barresi”Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, NeurosurgeryDepartment of Biomedical, Dental, Morphological and Functional Imaging Sciences, NeurosurgeryDepartment of Human Pathology in Adult and Developmental Age “Gaetano Barresi”Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”Among autophagic-related proteins, p62/SQSTM1/Sequestosome-1 represents a relevant actor in cellular proliferation and neoplastic growth. Although, recently, p62 expression has been analyzed in different neurodegenerative and glial neoplastic diseases, no available information have been reported in meningiomas, which have an high epidemiological relevance being the second most common category of intracranial tumors after gliomas. Generally meningiomas have a benign behavior, but their recurrence is not uncommon mainly when atypical or anaplastic varieties occur. However, intranuclear vacuoles have been ultrastructurally observed in meningiomas, and they were labelled by p62 antibodies. Therefore, in the present study, we have investigated p62 immunohistochemical pattern in a cohort of 133 cases representative of low- and high-grade meningiomas, to verify if p62 expression may be related to clinicopathological data, thus achieving a potential prognostic role. The p62 immunoexpression was frequently found in the nucleus and cytoplasm of neoplastic elements, and utilizing an intensity-distribution score, 55 (41.3%) cases were considered as high expressors while 78 (58.7%) cases were instead recorded as low expressors. Fifteen cases exhibited recurrences of the disease, 14 of which were codified as high expressors. Moreover, a direct relationship between p62 and Mib-1 immunoexpression as well as between p62 and neoplastic grade have been documented. Finally, we suggest that impaired autophagic flux with an increase in p62 expression may be involved in the activation of NRF2 also contributing in the development of recurrence in meningioma patients.http://dx.doi.org/10.1155/2024/5573892 |
| spellingShingle | Antonio Ieni Cristina Pizzimenti Vincenzo Fiorentino Mariausilia Franchina Antonino Germanò Giovanni Raffa Maurizio Martini Guido Fadda Giovanni Tuccari Immunohistochemical Profile of p62/SQSTM1/Sequestosome-1 in Human Low- and High-Grade Intracranial Meningiomas Analytical Cellular Pathology |
| title | Immunohistochemical Profile of p62/SQSTM1/Sequestosome-1 in Human Low- and High-Grade Intracranial Meningiomas |
| title_full | Immunohistochemical Profile of p62/SQSTM1/Sequestosome-1 in Human Low- and High-Grade Intracranial Meningiomas |
| title_fullStr | Immunohistochemical Profile of p62/SQSTM1/Sequestosome-1 in Human Low- and High-Grade Intracranial Meningiomas |
| title_full_unstemmed | Immunohistochemical Profile of p62/SQSTM1/Sequestosome-1 in Human Low- and High-Grade Intracranial Meningiomas |
| title_short | Immunohistochemical Profile of p62/SQSTM1/Sequestosome-1 in Human Low- and High-Grade Intracranial Meningiomas |
| title_sort | immunohistochemical profile of p62 sqstm1 sequestosome 1 in human low and high grade intracranial meningiomas |
| url | http://dx.doi.org/10.1155/2024/5573892 |
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