CREATE: cell-type-specific cis-regulatory element identification via discrete embedding

CREATE: cell-type-specific cis-regulatory element identification via discrete embedding

Abstract Cis-regulatory elements (CREs), including enhancers, silencers, promoters and insulators, play pivotal roles in orchestrating gene regulatory mechanisms that drive complex biological traits. However, current approaches for CRE identification are predominantly sequence-based and typically fo...

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Bibliographic Details
Main Authors: Xuejian Cui, Qijin Yin, Zijing Gao, Zhen Li, Xiaoyang Chen, Hairong Lv, Shengquan Chen, Qiao Liu, Wanwen Zeng, Rui Jiang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59780-5
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