Early-life gut microbiome associates with positive vaccine take and shedding in neonatal schedule of the human neonatal rotavirus vaccine RV3-BB

Early-life gut microbiome associates with positive vaccine take and shedding in neonatal schedule of the human neonatal rotavirus vaccine RV3-BB

Abstract Rotavirus vaccines are less effective in high mortality regions. A rotavirus vaccine administered at birth may overcome challenges to vaccine uptake posed by a complex gut microbiome. We investigated the association between the microbiome and vaccine responses following RV3-BB vaccine (G3P[...

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Main Authors: Josef Wagner, Amanda Handley, Celeste M. Donato, Eleanor A. Lyons, Daniel Pavlic, Darren Suryawijaya Ong, Rhian Bonnici, Nada Bogdanovic-Sakran, Edward P. K. Parker, Christina Bronowski, Jarir At Thobari, Cahya Dewi Satria, Hera Nirwati, Desiree Witte, Khuzwayo C. Jere, Ashley Mpakiza, Emma Watts, Ann Turner, Karen Boniface, Jonathan Mandolo, Frances Justice, Naor Bar-Zeev, Miren Iturriza-Gomara, Jim P. Buttery, Nigel A. Cunliffe, Yati Soenarto, Julie E. Bines
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58632-6
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