Carbon nanotubes in brain targeted drug delivery: A comprehensive review
The treatment of brain diseases remains a significant challenge in modern medicine, primarily due to the restrictive nature of the blood-brain barrier (BBB), which limits drug delivery. Carbon nanotubes (CNTs) have emerged as a promising strategy for overcoming this obstacle, providing an innovative...
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Elsevier
2025-05-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625001894 |
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| author | Sourav Das Sukanta Roy Subhas Chandra Dinda Anirbandeep Bose Chinmaya Mahapatra Biswajit Basu Bhupendra Prajapati |
| author_facet | Sourav Das Sukanta Roy Subhas Chandra Dinda Anirbandeep Bose Chinmaya Mahapatra Biswajit Basu Bhupendra Prajapati |
| author_sort | Sourav Das |
| collection | DOAJ |
| description | The treatment of brain diseases remains a significant challenge in modern medicine, primarily due to the restrictive nature of the blood-brain barrier (BBB), which limits drug delivery. Carbon nanotubes (CNTs) have emerged as a promising strategy for overcoming this obstacle, providing an innovative platform for targeted drug delivery to the brain. This review presents a detailed analysis of CNTs as drug carriers, with a particular emphasis on their application in brain tumor treatment. Their unique physicochemical properties, including a high surface area, tunable surface chemistry, and exceptional drug-loading capacity, make them ideal candidates for encapsulating and delivering therapeutic agents with precision. Functionalization with targeting ligands further enhances the specificity of CNTs, enabling drugs to reach brain tumors more effectively while minimizing off-target effects. The review examines advancements in CNT-based drug delivery systems, particularly their role in transporting chemotherapy drugs, nucleic acid-based therapies, and other small molecules across the BBB. It also highlights their potential to improve therapeutic efficacy while reducing systemic toxicity. Furthermore, the challenges and opportunities associated with CNT-based drug delivery, such as safety concerns, regulatory barriers, and clinical translation, are explored. The discussion extends to the development of multifunctional CNT platforms that combine imaging agents with therapeutic payloads, allowing for real-time tumor monitoring and treatment. Ultimately, this review provides insights into the potential of CNTs as carriers for brain-targeted drug delivery, offering a pathway toward more effective and less invasive brain tumor therapies. Understanding current advancements and addressing existing challenges will be crucial for realizing the full potential of CNT-based drug delivery in neuro-oncology. |
| format | Article |
| id | doaj-art-e3fb3e7982fc4e109c42599c095d82c2 |
| institution | OA Journals |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-e3fb3e7982fc4e109c42599c095d82c22025-08-20T02:09:18ZengElsevierResults in Chemistry2211-71562025-05-011510220610.1016/j.rechem.2025.102206Carbon nanotubes in brain targeted drug delivery: A comprehensive reviewSourav Das0Sukanta Roy1Subhas Chandra Dinda2Anirbandeep Bose3Chinmaya Mahapatra4Biswajit Basu5Bhupendra Prajapati6School of Pharmacy, The Neotia University, Sarisa, West Bengal, India 743368School of Pharmacy, The Neotia University, Sarisa, West Bengal, India 743368School of Pharmacy, The Neotia University, Sarisa, West Bengal, India 743368Department of Pharmaceutical Technology, School of Health & Medical Sciences, Adamas University, Barasat, Kolkata, West Bengal, 700126. IndiaSchool of Pharmacy, The Neotia University, Sarisa, West Bengal, India 743368; Corresponding author at: School of Pharmacy, The Neotia University, West Bengal, India.Department of Pharmaceutical Technology, School of Health & Medical Sciences, Adamas University, Barasat, Kolkata, West Bengal, 700126. IndiaS. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana, Gujarat, 384012, India; Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, 140401, Punjab, India; Corresponding author at: S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana, Gujarat, 384012, India.The treatment of brain diseases remains a significant challenge in modern medicine, primarily due to the restrictive nature of the blood-brain barrier (BBB), which limits drug delivery. Carbon nanotubes (CNTs) have emerged as a promising strategy for overcoming this obstacle, providing an innovative platform for targeted drug delivery to the brain. This review presents a detailed analysis of CNTs as drug carriers, with a particular emphasis on their application in brain tumor treatment. Their unique physicochemical properties, including a high surface area, tunable surface chemistry, and exceptional drug-loading capacity, make them ideal candidates for encapsulating and delivering therapeutic agents with precision. Functionalization with targeting ligands further enhances the specificity of CNTs, enabling drugs to reach brain tumors more effectively while minimizing off-target effects. The review examines advancements in CNT-based drug delivery systems, particularly their role in transporting chemotherapy drugs, nucleic acid-based therapies, and other small molecules across the BBB. It also highlights their potential to improve therapeutic efficacy while reducing systemic toxicity. Furthermore, the challenges and opportunities associated with CNT-based drug delivery, such as safety concerns, regulatory barriers, and clinical translation, are explored. The discussion extends to the development of multifunctional CNT platforms that combine imaging agents with therapeutic payloads, allowing for real-time tumor monitoring and treatment. Ultimately, this review provides insights into the potential of CNTs as carriers for brain-targeted drug delivery, offering a pathway toward more effective and less invasive brain tumor therapies. Understanding current advancements and addressing existing challenges will be crucial for realizing the full potential of CNT-based drug delivery in neuro-oncology.http://www.sciencedirect.com/science/article/pii/S2211715625001894Carbon nanotubeBrain-targeted drug deliveryBlood-brain barrier (BBB) |
| spellingShingle | Sourav Das Sukanta Roy Subhas Chandra Dinda Anirbandeep Bose Chinmaya Mahapatra Biswajit Basu Bhupendra Prajapati Carbon nanotubes in brain targeted drug delivery: A comprehensive review Results in Chemistry Carbon nanotube Brain-targeted drug delivery Blood-brain barrier (BBB) |
| title | Carbon nanotubes in brain targeted drug delivery: A comprehensive review |
| title_full | Carbon nanotubes in brain targeted drug delivery: A comprehensive review |
| title_fullStr | Carbon nanotubes in brain targeted drug delivery: A comprehensive review |
| title_full_unstemmed | Carbon nanotubes in brain targeted drug delivery: A comprehensive review |
| title_short | Carbon nanotubes in brain targeted drug delivery: A comprehensive review |
| title_sort | carbon nanotubes in brain targeted drug delivery a comprehensive review |
| topic | Carbon nanotube Brain-targeted drug delivery Blood-brain barrier (BBB) |
| url | http://www.sciencedirect.com/science/article/pii/S2211715625001894 |
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