Target protein identification in live cells and organisms with a non-diffusive proximity tagging system

Target protein identification in live cells and organisms with a non-diffusive proximity tagging system

Identifying target proteins for bioactive molecules is essential for understanding their mechanisms, developing improved derivatives, and minimizing off-target effects. Despite advances in target identification (target-ID) technologies, significant challenges remain, impeding drug development. Most...

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Bibliographic Details
Main Authors: Yingjie Sun, Changheng Li, Xiaofei Deng, Wenjie Li, Xiaoyi Deng, Weiqi Ge, Miaoyuan Shi, Ying Guo, Yanxun V Yu, Hai-bing Zhou, Youngnam N Jin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
proximity labeling
PafA
dasatinib
chloroquine
zebrafish
target identification
Online Access:https://elifesciences.org/articles/102667
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