Selank effects on morphine-induced analgesia <i>in vivo</i> experiments
Background. The endogenous opioid system is involved in neuroadaptation produced by exogenous opioids. Synthesized on the basis of the regulatory peptide tuftsin, the anxiolytic selank inhibits the activity of enkephalin-degrading enzymes, increasing the level of leu-enkephalins in blood plasma. T...
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| Language: | Russian |
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LLC “Publisher OKI”
2022-05-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/306 |
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| author | A. V. Nadorova I. V. Chernyakova L. G. Kolik |
| author_facet | A. V. Nadorova I. V. Chernyakova L. G. Kolik |
| author_sort | A. V. Nadorova |
| collection | DOAJ |
| description | Background. The endogenous opioid system is involved in neuroadaptation produced by exogenous opioids. Synthesized on the basis of the regulatory peptide tuftsin, the anxiolytic selank inhibits the activity of enkephalin-degrading enzymes, increasing the level of leu-enkephalins in blood plasma. The aim of the work was to evaluate the effect of selank (0,3 and 0,9 mg/kg, i. p.) on morphine-induced analgesia in animal models. Methods. The experiments were performed in inbred male mice C57Bl/6 (n = 77). The “hot plate” test was used to evaluate the analgesic effect during thermal stimulation of nociceptors when mice were placed on a metal plate heated to 55 ± 0,5 °C, followed by registration of the latent period of the reaction 30, 60, 90, and 120 minutes after the administration of morphine. Results. Morphine at a dose of 3,0 mg/kg, i. p., caused antinociception with the maximum possible effect (MBE) of 9 %, selank at a dose of 0,9 mg/kg, without antinociception per se, when pretreated with the morphine, increased the latent reaction time, causing antinociception of 29,9 % MBE. Conclusion. For the first time the data obtained on the synergistic effect of selank and morphine in attenuation of acute somatic pain. |
| format | Article |
| id | doaj-art-e3f694e02bc54d66b87837c1dba150d7 |
| institution | DOAJ |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2022-05-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-e3f694e02bc54d66b87837c1dba150d72025-08-20T03:19:57ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302022-05-0101303510.37489/2587-7836-2022-1-30-35293Selank effects on morphine-induced analgesia <i>in vivo</i> experimentsA. V. Nadorova0I. V. Chernyakova1L. G. Kolik2FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”FSBI “Zakusov Institute of Pharmacology”; RASBackground. The endogenous opioid system is involved in neuroadaptation produced by exogenous opioids. Synthesized on the basis of the regulatory peptide tuftsin, the anxiolytic selank inhibits the activity of enkephalin-degrading enzymes, increasing the level of leu-enkephalins in blood plasma. The aim of the work was to evaluate the effect of selank (0,3 and 0,9 mg/kg, i. p.) on morphine-induced analgesia in animal models. Methods. The experiments were performed in inbred male mice C57Bl/6 (n = 77). The “hot plate” test was used to evaluate the analgesic effect during thermal stimulation of nociceptors when mice were placed on a metal plate heated to 55 ± 0,5 °C, followed by registration of the latent period of the reaction 30, 60, 90, and 120 minutes after the administration of morphine. Results. Morphine at a dose of 3,0 mg/kg, i. p., caused antinociception with the maximum possible effect (MBE) of 9 %, selank at a dose of 0,9 mg/kg, without antinociception per se, when pretreated with the morphine, increased the latent reaction time, causing antinociception of 29,9 % MBE. Conclusion. For the first time the data obtained on the synergistic effect of selank and morphine in attenuation of acute somatic pain.https://www.pharmacokinetica.ru/jour/article/view/306morphineselankanalgesiadrug interactionmice |
| spellingShingle | A. V. Nadorova I. V. Chernyakova L. G. Kolik Selank effects on morphine-induced analgesia <i>in vivo</i> experiments Фармакокинетика и Фармакодинамика morphine selank analgesia drug interaction mice |
| title | Selank effects on morphine-induced analgesia <i>in vivo</i> experiments |
| title_full | Selank effects on morphine-induced analgesia <i>in vivo</i> experiments |
| title_fullStr | Selank effects on morphine-induced analgesia <i>in vivo</i> experiments |
| title_full_unstemmed | Selank effects on morphine-induced analgesia <i>in vivo</i> experiments |
| title_short | Selank effects on morphine-induced analgesia <i>in vivo</i> experiments |
| title_sort | selank effects on morphine induced analgesia i in vivo i experiments |
| topic | morphine selank analgesia drug interaction mice |
| url | https://www.pharmacokinetica.ru/jour/article/view/306 |
| work_keys_str_mv | AT avnadorova selankeffectsonmorphineinducedanalgesiaiinvivoiexperiments AT ivchernyakova selankeffectsonmorphineinducedanalgesiaiinvivoiexperiments AT lgkolik selankeffectsonmorphineinducedanalgesiaiinvivoiexperiments |