Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection

Gasdermin E deficiency limits inflammation and lung damage during influenza virus infection

Abstract Severe influenza A virus (IAV) infections are associated with hyperinflammation and significant lung damage. Gasdermin E (GSDME) mediates pyroptosis, a lytic and inflammatory type of cell death. Cleavage of GSDME by caspase-3 releases the active N-terminal domain, which subsequently forms t...

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Bibliographic Details
Main Authors: Sarah Rosli, Rebecca L. Ambrose, Christopher M. Harpur, Maggie Lam, Christopher Hodges, Kristian T. Barry, Alison C. West, Ashley Mansell, Kate E. Lawlor, Michelle D. Tate
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07748-0
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