Parkinson’s Disease in Central Asian and Transcaucasian Countries: A Review of Epidemiology, Genetics, Clinical Characteristics, and Access to Care
Our understanding of Parkinson’s disease (PD) has significantly accelerated over the last few years, but predominant advances have been made in developed, Western countries. Little is known about PD in the Central Asian (CA) and Transcaucasian (TC) countries. Here, we review the clinical characteris...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2019/2905739 |
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| author | Rauan Kaiyrzhanov Mie Rizig Akbota Aitkulova Nazira Zharkinbekova Chingiz Shashkin Gulnaz Kaishibayeva Altynay Karimova Talgat Khaibullin Dinara Sadykova Manizha Ganieva Khurshidakhon Rasulova Henry Houlden |
| author_facet | Rauan Kaiyrzhanov Mie Rizig Akbota Aitkulova Nazira Zharkinbekova Chingiz Shashkin Gulnaz Kaishibayeva Altynay Karimova Talgat Khaibullin Dinara Sadykova Manizha Ganieva Khurshidakhon Rasulova Henry Houlden |
| author_sort | Rauan Kaiyrzhanov |
| collection | DOAJ |
| description | Our understanding of Parkinson’s disease (PD) has significantly accelerated over the last few years, but predominant advances have been made in developed, Western countries. Little is known about PD in the Central Asian (CA) and Transcaucasian (TC) countries. Here, we review the clinical characteristics, treatments used, epidemiology, and genetics of PD in CA and TC countries via a methodological search in MEDLINE, EMBASE, Scopus, Web of Science, and Google Scholar databases. For the acquisition of PD care-related data, the search was extended to the local web resources. Our findings showed that PD prevalence in the region is averaging 62 per 100,000 population. The mean age of onset is 56.4 ± 2.8 in females and 63.3 ± 3.5 in males. Large-scale national studies on PD prevalence from the region are currently lacking. A limited number of genetic studies with small cohorts and inconclusive results were identified. The G2019S LRRK2 mutation, the commonest mutation in PD worldwide, was found in 5.7% of patients with idiopathic PD and 17.6% of familial cases in 153 Uzbek patients. Our review highlighted systematic deficiencies in PD health care in the region including lacks of neurologists specializing in PD, delays in PD diagnosis, absence of specialized PD nurses and PD rehab services, limited access to PD medications and surgery, and the unavailability of PD infusion therapies. Overall, this article demonstrated the paucity of data on this common neurological disorder in CA and TC countries and identified a number of healthcare areas that require an urgent consideration. We conclude that well-designed large-scale epidemiological, genetic, and clinical studies are desperately needed in this region. Healthcare professionals, local and national institutions, and stakeholders must come together to address deficiencies in PD healthcare systems in CA and TC countries. |
| format | Article |
| id | doaj-art-e3f28fd22b6a4a5aa21ba47e3b83688a |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-e3f28fd22b6a4a5aa21ba47e3b83688a2025-08-20T03:26:33ZengWileyParkinson's Disease2090-80832042-00802019-01-01201910.1155/2019/29057392905739Parkinson’s Disease in Central Asian and Transcaucasian Countries: A Review of Epidemiology, Genetics, Clinical Characteristics, and Access to CareRauan Kaiyrzhanov0Mie Rizig1Akbota Aitkulova2Nazira Zharkinbekova3Chingiz Shashkin4Gulnaz Kaishibayeva5Altynay Karimova6Talgat Khaibullin7Dinara Sadykova8Manizha Ganieva9Khurshidakhon Rasulova10Henry Houlden11University College London, Institute of Neurology, Department of Neuromuscular Disorders, Queen Square, WC1N 3BG London, UKUniversity College London, Institute of Neurology, Department of Neuromuscular Disorders, Queen Square, WC1N 3BG London, UKAl-Farabi Kazakh National University, Department of Biology and Biotechnology, 71 Al-Farabi Ave., 050040 Almaty, KazakhstanSouth Kazakhstan Medical Academy, Department of Neurology, 1/1 Al-Farabi Avenue, 160019 Shymkent, KazakhstanKazakh National Medical University, Department of Neurology, 94 Tole Bi Street, 050000 Almaty, KazakhstanInstitute of Neurology Named After S.K. Kaishibayev, 9a Mamur 4 Microdistrict, 050000 Almaty, KazakhstanInstitute of Neurology Named After S.K. Kaishibayev, 9a Mamur 4 Microdistrict, 050000 Almaty, KazakhstanSemey Medical University, Department of Neurology and Neurophysiology, 103 Abai Street, 071400 Semey, KazakhstanAstana Medical University, 49A Beibitshilik Street, 01000 Nur-Sultan, KazakhstanAvicenna Tajik State Medical University, Department of Neurology and Medical Genetics, 139 Rudaki Street, 734001 Dushanbe, TajikistanTashkent Pediatric Medical Institute, Department of Internal Diseases and Research Laboratory, 223 Bogishamol Street, 100140 Tashkent, UzbekistanUniversity College London, Institute of Neurology, Department of Neuromuscular Disorders, Queen Square, WC1N 3BG London, UKOur understanding of Parkinson’s disease (PD) has significantly accelerated over the last few years, but predominant advances have been made in developed, Western countries. Little is known about PD in the Central Asian (CA) and Transcaucasian (TC) countries. Here, we review the clinical characteristics, treatments used, epidemiology, and genetics of PD in CA and TC countries via a methodological search in MEDLINE, EMBASE, Scopus, Web of Science, and Google Scholar databases. For the acquisition of PD care-related data, the search was extended to the local web resources. Our findings showed that PD prevalence in the region is averaging 62 per 100,000 population. The mean age of onset is 56.4 ± 2.8 in females and 63.3 ± 3.5 in males. Large-scale national studies on PD prevalence from the region are currently lacking. A limited number of genetic studies with small cohorts and inconclusive results were identified. The G2019S LRRK2 mutation, the commonest mutation in PD worldwide, was found in 5.7% of patients with idiopathic PD and 17.6% of familial cases in 153 Uzbek patients. Our review highlighted systematic deficiencies in PD health care in the region including lacks of neurologists specializing in PD, delays in PD diagnosis, absence of specialized PD nurses and PD rehab services, limited access to PD medications and surgery, and the unavailability of PD infusion therapies. Overall, this article demonstrated the paucity of data on this common neurological disorder in CA and TC countries and identified a number of healthcare areas that require an urgent consideration. We conclude that well-designed large-scale epidemiological, genetic, and clinical studies are desperately needed in this region. Healthcare professionals, local and national institutions, and stakeholders must come together to address deficiencies in PD healthcare systems in CA and TC countries.http://dx.doi.org/10.1155/2019/2905739 |
| spellingShingle | Rauan Kaiyrzhanov Mie Rizig Akbota Aitkulova Nazira Zharkinbekova Chingiz Shashkin Gulnaz Kaishibayeva Altynay Karimova Talgat Khaibullin Dinara Sadykova Manizha Ganieva Khurshidakhon Rasulova Henry Houlden Parkinson’s Disease in Central Asian and Transcaucasian Countries: A Review of Epidemiology, Genetics, Clinical Characteristics, and Access to Care Parkinson's Disease |
| title | Parkinson’s Disease in Central Asian and Transcaucasian Countries: A Review of Epidemiology, Genetics, Clinical Characteristics, and Access to Care |
| title_full | Parkinson’s Disease in Central Asian and Transcaucasian Countries: A Review of Epidemiology, Genetics, Clinical Characteristics, and Access to Care |
| title_fullStr | Parkinson’s Disease in Central Asian and Transcaucasian Countries: A Review of Epidemiology, Genetics, Clinical Characteristics, and Access to Care |
| title_full_unstemmed | Parkinson’s Disease in Central Asian and Transcaucasian Countries: A Review of Epidemiology, Genetics, Clinical Characteristics, and Access to Care |
| title_short | Parkinson’s Disease in Central Asian and Transcaucasian Countries: A Review of Epidemiology, Genetics, Clinical Characteristics, and Access to Care |
| title_sort | parkinson s disease in central asian and transcaucasian countries a review of epidemiology genetics clinical characteristics and access to care |
| url | http://dx.doi.org/10.1155/2019/2905739 |
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