8-Oxo-2’-deoxyguanosine – biomarker of the oxidative stress
Free radical mechanism of a cell damage is one of the universal non-specific pathogenic pathways in a cause of many diseases, including cancer, neurodegenerative diseases, atherosclerosis and aging. So in nuclear and mitochondrial DNA, guanine hydroxylation to 8-position gives 8hydroxy2'deox...
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MIREA - Russian Technological University
2014-10-01
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| Series: | Тонкие химические технологии |
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| Online Access: | https://www.finechem-mirea.ru/jour/article/view/431 |
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| author | T. S. Nevredimova N. V. Marmiy D. S. Esipov O. V. Esipova V. I. Shvets |
| author_facet | T. S. Nevredimova N. V. Marmiy D. S. Esipov O. V. Esipova V. I. Shvets |
| author_sort | T. S. Nevredimova |
| collection | DOAJ |
| description | Free radical mechanism of a cell damage is one of the universal non-specific pathogenic pathways in a cause of many diseases, including cancer, neurodegenerative diseases, atherosclerosis and aging. So in nuclear and mitochondrial DNA, guanine hydroxylation to 8-position gives 8hydroxy2'deoxyguanosine (8OHdG) and 8oxo7,8dihydro2'deoxyguanosine (8oxodG). These substances are one of the predominant products of free radicalinduced oxidative damages. They are usually been applied as biomarkers of oxidative stress and carcinogenesis. The direct oxidation of guanine or incorrect inclusion of 8-oxo-dGTP from the nucleotide pool by polymerases, lead to a lack of specificity of the base pairing in DNA, favoring mutagenesis. Firstly 8-oxo-dG has been described by H. Kasai and S. Nishimura in 1983. Since then, this damage has been widely measured in various tissues and body fluids as blood, urine, brain, liver, and others. Today 8-oxo-dG is already used not only as a marker of oxidative stress, but also as a tool for prognosis of diseases and results of applied therapy. Now many efforts are focused on developing the procedure of measurement of 8-oxo-dG content in tissues and body fluids. In this paper we also discuss the role of the 8-oxo-dG as a biomarker of oxidative stress and a predictor of diseases and results of the applied therapy. |
| format | Article |
| id | doaj-art-e3f1e1f344d94f5f8c552430da66b872 |
| institution | DOAJ |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| publishDate | 2014-10-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj-art-e3f1e1f344d94f5f8c552430da66b8722025-08-20T03:23:08ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752014-10-01953104258-Oxo-2’-deoxyguanosine – biomarker of the oxidative stressT. S. Nevredimova0N. V. Marmiy1D. S. Esipov2O. V. Esipova3V. I. Shvets4МИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86Московский государственный университет им. М.В. Ломоносова, Москва, 119991Московский государственный университет им. М.В. Ломоносова, Москва, 119991M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571Free radical mechanism of a cell damage is one of the universal non-specific pathogenic pathways in a cause of many diseases, including cancer, neurodegenerative diseases, atherosclerosis and aging. So in nuclear and mitochondrial DNA, guanine hydroxylation to 8-position gives 8hydroxy2'deoxyguanosine (8OHdG) and 8oxo7,8dihydro2'deoxyguanosine (8oxodG). These substances are one of the predominant products of free radicalinduced oxidative damages. They are usually been applied as biomarkers of oxidative stress and carcinogenesis. The direct oxidation of guanine or incorrect inclusion of 8-oxo-dGTP from the nucleotide pool by polymerases, lead to a lack of specificity of the base pairing in DNA, favoring mutagenesis. Firstly 8-oxo-dG has been described by H. Kasai and S. Nishimura in 1983. Since then, this damage has been widely measured in various tissues and body fluids as blood, urine, brain, liver, and others. Today 8-oxo-dG is already used not only as a marker of oxidative stress, but also as a tool for prognosis of diseases and results of applied therapy. Now many efforts are focused on developing the procedure of measurement of 8-oxo-dG content in tissues and body fluids. In this paper we also discuss the role of the 8-oxo-dG as a biomarker of oxidative stress and a predictor of diseases and results of the applied therapy.https://www.finechem-mirea.ru/jour/article/view/431: 8-oxo-2’-deoxyguanosine, oxidative stress, biomarker of oxidative stress. |
| spellingShingle | T. S. Nevredimova N. V. Marmiy D. S. Esipov O. V. Esipova V. I. Shvets 8-Oxo-2’-deoxyguanosine – biomarker of the oxidative stress Тонкие химические технологии : 8-oxo-2’-deoxyguanosine, oxidative stress, biomarker of oxidative stress. |
| title | 8-Oxo-2’-deoxyguanosine – biomarker of the oxidative stress |
| title_full | 8-Oxo-2’-deoxyguanosine – biomarker of the oxidative stress |
| title_fullStr | 8-Oxo-2’-deoxyguanosine – biomarker of the oxidative stress |
| title_full_unstemmed | 8-Oxo-2’-deoxyguanosine – biomarker of the oxidative stress |
| title_short | 8-Oxo-2’-deoxyguanosine – biomarker of the oxidative stress |
| title_sort | 8 oxo 2 deoxyguanosine biomarker of the oxidative stress |
| topic | : 8-oxo-2’-deoxyguanosine, oxidative stress, biomarker of oxidative stress. |
| url | https://www.finechem-mirea.ru/jour/article/view/431 |
| work_keys_str_mv | AT tsnevredimova 8oxo2deoxyguanosinebiomarkeroftheoxidativestress AT nvmarmiy 8oxo2deoxyguanosinebiomarkeroftheoxidativestress AT dsesipov 8oxo2deoxyguanosinebiomarkeroftheoxidativestress AT ovesipova 8oxo2deoxyguanosinebiomarkeroftheoxidativestress AT vishvets 8oxo2deoxyguanosinebiomarkeroftheoxidativestress |