PEDOT:PSS-based bioelectronics for brain monitoring and modulation
Abstract The growing demand for advanced neural interfaces that enable precise brain monitoring and modulation has catalyzed significant research into flexible, biocompatible, and highly conductive materials. PEDOT:PSS-based bioelectronic materials exhibit high conductivity, mechanical flexibility,...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-05-01
|
| Series: | Microsystems & Nanoengineering |
| Online Access: | https://doi.org/10.1038/s41378-025-00948-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849724801617231872 |
|---|---|
| author | Jing Li Daize Mo Jinyuan Hu Shichao Wang Jun Gong Yujing Huang Zheng Li Zhen Yuan Mengze Xu |
| author_facet | Jing Li Daize Mo Jinyuan Hu Shichao Wang Jun Gong Yujing Huang Zheng Li Zhen Yuan Mengze Xu |
| author_sort | Jing Li |
| collection | DOAJ |
| description | Abstract The growing demand for advanced neural interfaces that enable precise brain monitoring and modulation has catalyzed significant research into flexible, biocompatible, and highly conductive materials. PEDOT:PSS-based bioelectronic materials exhibit high conductivity, mechanical flexibility, and biocompatibility, making them particularly suitable for integration into neural devices for brain science research. These materials facilitate high-resolution neural activity monitoring and provide precise electrical stimulation across diverse modalities. This review comprehensively examines recent advances in the development of PEDOT:PSS-based bioelectrodes for brain monitoring and modulation, with a focus on strategies to enhance their conductivity, biocompatibility, and long-term stability. Furthermore, it highlights the integration of multifunctional neural interfaces that enable synchronous stimulation-recording architectures, hybrid electro-optical stimulation modalities, and multimodal brain activity monitoring. These integrations enable fundamentally advancing the precision and clinical translatability of brain–computer interfaces. By addressing critical challenges related to efficacy, integration, safety, and clinical translation, this review identifies key opportunities for advancing next-generation neural devices. The insights presented are vital for guiding future research directions in the field and fostering the development of cutting-edge bioelectronic technologies for neuroscience and clinical applications. |
| format | Article |
| id | doaj-art-e3ecec71f49f4c8193f6147ef5f6636a |
| institution | DOAJ |
| issn | 2055-7434 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Microsystems & Nanoengineering |
| spelling | doaj-art-e3ecec71f49f4c8193f6147ef5f6636a2025-08-20T03:10:38ZengNature Publishing GroupMicrosystems & Nanoengineering2055-74342025-05-0111112810.1038/s41378-025-00948-wPEDOT:PSS-based bioelectronics for brain monitoring and modulationJing Li0Daize Mo1Jinyuan Hu2Shichao Wang3Jun Gong4Yujing Huang5Zheng Li6Zhen Yuan7Mengze Xu8Faculty of Arts and Sciences, Beijing Normal UniversitySchool of Applied Physics and Materials, Wuyi UniversityFaculty of Arts and Sciences, Beijing Normal UniversityFaculty of Arts and Sciences, Beijing Normal UniversityCentral Laboratory of YunFu People’s HospitalCentre for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of MacauDepartment of Psychology, Faculty of Arts and Sciences, Center for Cognition and Neuroergonomics, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal UniversityCentre for Cognitive and Brain Sciences, Institute of Collaborative Innovation, University of MacauFaculty of Arts and Sciences, Beijing Normal UniversityAbstract The growing demand for advanced neural interfaces that enable precise brain monitoring and modulation has catalyzed significant research into flexible, biocompatible, and highly conductive materials. PEDOT:PSS-based bioelectronic materials exhibit high conductivity, mechanical flexibility, and biocompatibility, making them particularly suitable for integration into neural devices for brain science research. These materials facilitate high-resolution neural activity monitoring and provide precise electrical stimulation across diverse modalities. This review comprehensively examines recent advances in the development of PEDOT:PSS-based bioelectrodes for brain monitoring and modulation, with a focus on strategies to enhance their conductivity, biocompatibility, and long-term stability. Furthermore, it highlights the integration of multifunctional neural interfaces that enable synchronous stimulation-recording architectures, hybrid electro-optical stimulation modalities, and multimodal brain activity monitoring. These integrations enable fundamentally advancing the precision and clinical translatability of brain–computer interfaces. By addressing critical challenges related to efficacy, integration, safety, and clinical translation, this review identifies key opportunities for advancing next-generation neural devices. The insights presented are vital for guiding future research directions in the field and fostering the development of cutting-edge bioelectronic technologies for neuroscience and clinical applications.https://doi.org/10.1038/s41378-025-00948-w |
| spellingShingle | Jing Li Daize Mo Jinyuan Hu Shichao Wang Jun Gong Yujing Huang Zheng Li Zhen Yuan Mengze Xu PEDOT:PSS-based bioelectronics for brain monitoring and modulation Microsystems & Nanoengineering |
| title | PEDOT:PSS-based bioelectronics for brain monitoring and modulation |
| title_full | PEDOT:PSS-based bioelectronics for brain monitoring and modulation |
| title_fullStr | PEDOT:PSS-based bioelectronics for brain monitoring and modulation |
| title_full_unstemmed | PEDOT:PSS-based bioelectronics for brain monitoring and modulation |
| title_short | PEDOT:PSS-based bioelectronics for brain monitoring and modulation |
| title_sort | pedot pss based bioelectronics for brain monitoring and modulation |
| url | https://doi.org/10.1038/s41378-025-00948-w |
| work_keys_str_mv | AT jingli pedotpssbasedbioelectronicsforbrainmonitoringandmodulation AT daizemo pedotpssbasedbioelectronicsforbrainmonitoringandmodulation AT jinyuanhu pedotpssbasedbioelectronicsforbrainmonitoringandmodulation AT shichaowang pedotpssbasedbioelectronicsforbrainmonitoringandmodulation AT jungong pedotpssbasedbioelectronicsforbrainmonitoringandmodulation AT yujinghuang pedotpssbasedbioelectronicsforbrainmonitoringandmodulation AT zhengli pedotpssbasedbioelectronicsforbrainmonitoringandmodulation AT zhenyuan pedotpssbasedbioelectronicsforbrainmonitoringandmodulation AT mengzexu pedotpssbasedbioelectronicsforbrainmonitoringandmodulation |