A retrospective study of an irradiation-based conditioning regimen and chidamide maintenance therapy in T-ALL/LBL
Objectives T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) are highly malignant and aggressive hematologic tumors for which there is no standard first-line treatment. Chidamide, a novel histone deacetylase inhibitor, shows great promise. We assessed the efficacy and safety of...
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Taylor & Francis Group
2024-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2024.2356300 |
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| author | Xueying Wang Yan Deng Guangcui He Sihan Lai Yecheng Li Shan Zhang Ying He Ying Han Lilan Zhang Yi Su Fang Liu Hai Yi |
| author_facet | Xueying Wang Yan Deng Guangcui He Sihan Lai Yecheng Li Shan Zhang Ying He Ying Han Lilan Zhang Yi Su Fang Liu Hai Yi |
| author_sort | Xueying Wang |
| collection | DOAJ |
| description | Objectives T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) are highly malignant and aggressive hematologic tumors for which there is no standard first-line treatment. Chidamide, a novel histone deacetylase inhibitor, shows great promise. We assessed the efficacy and safety of an irradiation-containing conditioning regimen for allogeneic hematopoietic stem cell transplantation (allo-HSCT) and post-transplantation chidamide maintenance in patients with T-ALL/LBL.Methods We retrospectively analyzed the clinical data of six patients with T-ALL/LBL who underwent allo-HSCT with a radiotherapy-containing pretreatment regimen and post-transplant chidamide maintenance therapy. The endpoints were relapse, graft-versus-host disease (GVHD), transplant-related mortality (TRM), progression-free survival (PFS), overall survival (OS), and adverse events (AEs).Results All of the patients had uneventful post-transplant hematopoietic reconstitution, and all achieved complete molecular remission within 30 days. All six patients survived, and two relapsed with a median relapse time of 828.5 (170–1335) days. The 1-year OS rate was 100%, the 2-year PFS rate was 66.7%, and the TRM rate was 0%. After transplantation, two patients developed grade I-II acute GVHD (2/6); grade III-IV acute and chronic GVHD were not observed. The most common AEs following chidamide administration were hematological AEs, which occurred to varying degrees in all patients; liver function abnormalities occurred in two patients (grade 2), and symptoms of malaise occurred in one patient (grade 1).Conclusion Chidamide maintenance therapy after T-ALL/LBL transplantation is safe, but the efficacy needs to be further investigated. |
| format | Article |
| id | doaj-art-e3e9b29fdc34431f93e672732b73b647 |
| institution | DOAJ |
| issn | 1607-8454 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj-art-e3e9b29fdc34431f93e672732b73b6472025-08-20T02:50:19ZengTaylor & Francis GroupHematology1607-84542024-12-0129110.1080/16078454.2024.2356300A retrospective study of an irradiation-based conditioning regimen and chidamide maintenance therapy in T-ALL/LBLXueying Wang0Yan Deng1Guangcui He2Sihan Lai3Yecheng Li4Shan Zhang5Ying He6Ying Han7Lilan Zhang8Yi Su9Fang Liu10Hai Yi11Department of Hematology, The General Hospital of Western Theater Command, PLA, Chengdu, People’s Republic of ChinaDepartment of Hematology, The General Hospital of Western Theater Command, PLA, Chengdu, People’s Republic of ChinaDepartment of Hematology, The General Hospital of Western Theater Command, PLA, Chengdu, People’s Republic of ChinaDepartment of Hematology, The General Hospital of Western Theater Command, PLA, Chengdu, People’s Republic of ChinaDepartment of Hematology, Chengdu BOE Hospital, Chengdu, People’s Republic of ChinaDepartment of Hematology, The General Hospital of Western Theater Command, PLA, Chengdu, People’s Republic of ChinaDepartment of Hematology, The General Hospital of Western Theater Command, PLA, Chengdu, People’s Republic of ChinaDepartment of Hematology, The General Hospital of Western Theater Command, PLA, Chengdu, People’s Republic of ChinaDepartment of Hematology, The Affiliated Hospital of Chengdu University, Chengdu, People’s Republic of ChinaDepartment of Hematology, The General Hospital of Western Theater Command, PLA, Chengdu, People’s Republic of ChinaDepartment of Hematology, Chengdu BOE Hospital, Chengdu, People’s Republic of ChinaDepartment of Hematology, The General Hospital of Western Theater Command, PLA, Chengdu, People’s Republic of ChinaObjectives T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) are highly malignant and aggressive hematologic tumors for which there is no standard first-line treatment. Chidamide, a novel histone deacetylase inhibitor, shows great promise. We assessed the efficacy and safety of an irradiation-containing conditioning regimen for allogeneic hematopoietic stem cell transplantation (allo-HSCT) and post-transplantation chidamide maintenance in patients with T-ALL/LBL.Methods We retrospectively analyzed the clinical data of six patients with T-ALL/LBL who underwent allo-HSCT with a radiotherapy-containing pretreatment regimen and post-transplant chidamide maintenance therapy. The endpoints were relapse, graft-versus-host disease (GVHD), transplant-related mortality (TRM), progression-free survival (PFS), overall survival (OS), and adverse events (AEs).Results All of the patients had uneventful post-transplant hematopoietic reconstitution, and all achieved complete molecular remission within 30 days. All six patients survived, and two relapsed with a median relapse time of 828.5 (170–1335) days. The 1-year OS rate was 100%, the 2-year PFS rate was 66.7%, and the TRM rate was 0%. After transplantation, two patients developed grade I-II acute GVHD (2/6); grade III-IV acute and chronic GVHD were not observed. The most common AEs following chidamide administration were hematological AEs, which occurred to varying degrees in all patients; liver function abnormalities occurred in two patients (grade 2), and symptoms of malaise occurred in one patient (grade 1).Conclusion Chidamide maintenance therapy after T-ALL/LBL transplantation is safe, but the efficacy needs to be further investigated.https://www.tandfonline.com/doi/10.1080/16078454.2024.2356300LeukemiaT-ALL/LBLallogeneic hematopoietic stem cell transplantationhistone deacetylase inhibitorschidamidemaintenance therapy |
| spellingShingle | Xueying Wang Yan Deng Guangcui He Sihan Lai Yecheng Li Shan Zhang Ying He Ying Han Lilan Zhang Yi Su Fang Liu Hai Yi A retrospective study of an irradiation-based conditioning regimen and chidamide maintenance therapy in T-ALL/LBL Hematology Leukemia T-ALL/LBL allogeneic hematopoietic stem cell transplantation histone deacetylase inhibitors chidamide maintenance therapy |
| title | A retrospective study of an irradiation-based conditioning regimen and chidamide maintenance therapy in T-ALL/LBL |
| title_full | A retrospective study of an irradiation-based conditioning regimen and chidamide maintenance therapy in T-ALL/LBL |
| title_fullStr | A retrospective study of an irradiation-based conditioning regimen and chidamide maintenance therapy in T-ALL/LBL |
| title_full_unstemmed | A retrospective study of an irradiation-based conditioning regimen and chidamide maintenance therapy in T-ALL/LBL |
| title_short | A retrospective study of an irradiation-based conditioning regimen and chidamide maintenance therapy in T-ALL/LBL |
| title_sort | retrospective study of an irradiation based conditioning regimen and chidamide maintenance therapy in t all lbl |
| topic | Leukemia T-ALL/LBL allogeneic hematopoietic stem cell transplantation histone deacetylase inhibitors chidamide maintenance therapy |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2024.2356300 |
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