Reference ranges of CT quantitative indexes based on paired inspiratory and expiratory chest CT in healthy Chinese adults: A community-based cohort study
Purpose: Computed tomography (CT) screening has established itself as the routine method to monitor lung conditions by providing pulmonary structural and functional information. However, the reference ranges of CT indices are still lacking. Therefore, this study aimed to provide reference ranges for...
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KeAi Communications Co., Ltd.
2025-06-01
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| Series: | Meta-Radiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950162825000220 |
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| author | Ziwei Zhang Xiuxiu Zhou Yi Xia Qianxi Jin Yu Guan Taohu Zhou Yueze Li Shiyuan Liu Li Fan |
| author_facet | Ziwei Zhang Xiuxiu Zhou Yi Xia Qianxi Jin Yu Guan Taohu Zhou Yueze Li Shiyuan Liu Li Fan |
| author_sort | Ziwei Zhang |
| collection | DOAJ |
| description | Purpose: Computed tomography (CT) screening has established itself as the routine method to monitor lung conditions by providing pulmonary structural and functional information. However, the reference ranges of CT indices are still lacking. Therefore, this study aimed to provide reference ranges for CT quantitative indexes in healthy middle-aged and elderly Chinese population. Materials and Methods: A total of 783 healthy Chinese adults attending our hospital for the NELCIN-B3 protocol were enrolled. Paired inspiratory and expiratory chest CT and pulmonary function tests (PFTs) were performed in all subjects, CT indices based on density and parametric response map (PRM) were obtained, and PFTs and CT data were retrospectively collected. The reference range was obtained with the Lambda-Mu-Sigma model. Independent-sample t-test/one-way ANOVA analysis or Mann-Whitney test/Kruskal-Wallis test were conducted to compare mean values between different groups. Spearman correlation analysis was used to evaluate the correlation between spirometric and CT quantitative indices. Results: A total of 783 healthy subjects (255 men, 67 (63–69) years) were included. The reference ranges of lung volume, the percentage of low attenuation area (LAA (%)), PRMEmphy (%) and PRMfSAD (%) concerning age based on gender were established. LAA (%), PRMEmphy (%) and PRMfSAD (%) were significant higher in the upper lobes than in the lower lobes. There was a strong positive correlation between PRMEmphy (%) and PRMfSAD (%) (r = 0.62, p < 0.001). Conclusions: We established Chinese reference ranges for CT quantitative indexes in the population aged from 40 to 75 years old. |
| format | Article |
| id | doaj-art-e3dfc3ca0e3c45a0ad071a8782818bf4 |
| institution | DOAJ |
| issn | 2950-1628 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Meta-Radiology |
| spelling | doaj-art-e3dfc3ca0e3c45a0ad071a8782818bf42025-08-20T03:12:38ZengKeAi Communications Co., Ltd.Meta-Radiology2950-16282025-06-013210015410.1016/j.metrad.2025.100154Reference ranges of CT quantitative indexes based on paired inspiratory and expiratory chest CT in healthy Chinese adults: A community-based cohort studyZiwei Zhang0Xiuxiu Zhou1Yi Xia2Qianxi Jin3Yu Guan4Taohu Zhou5Yueze Li6Shiyuan Liu7Li Fan8Department of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, ChinaDepartment of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, ChinaDepartment of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, ChinaDepartment of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, ChinaDepartment of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, ChinaDepartment of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, ChinaDepartment of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China; School of Medical Imaging, Shandong Second Medical University, Weifang, 261053, Shandong, ChinaDepartment of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, ChinaDepartment of Radiology, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China; Corresponding author.Purpose: Computed tomography (CT) screening has established itself as the routine method to monitor lung conditions by providing pulmonary structural and functional information. However, the reference ranges of CT indices are still lacking. Therefore, this study aimed to provide reference ranges for CT quantitative indexes in healthy middle-aged and elderly Chinese population. Materials and Methods: A total of 783 healthy Chinese adults attending our hospital for the NELCIN-B3 protocol were enrolled. Paired inspiratory and expiratory chest CT and pulmonary function tests (PFTs) were performed in all subjects, CT indices based on density and parametric response map (PRM) were obtained, and PFTs and CT data were retrospectively collected. The reference range was obtained with the Lambda-Mu-Sigma model. Independent-sample t-test/one-way ANOVA analysis or Mann-Whitney test/Kruskal-Wallis test were conducted to compare mean values between different groups. Spearman correlation analysis was used to evaluate the correlation between spirometric and CT quantitative indices. Results: A total of 783 healthy subjects (255 men, 67 (63–69) years) were included. The reference ranges of lung volume, the percentage of low attenuation area (LAA (%)), PRMEmphy (%) and PRMfSAD (%) concerning age based on gender were established. LAA (%), PRMEmphy (%) and PRMfSAD (%) were significant higher in the upper lobes than in the lower lobes. There was a strong positive correlation between PRMEmphy (%) and PRMfSAD (%) (r = 0.62, p < 0.001). Conclusions: We established Chinese reference ranges for CT quantitative indexes in the population aged from 40 to 75 years old.http://www.sciencedirect.com/science/article/pii/S2950162825000220Reference rangeChest phantomPaired inspiratory and expiratory chest CT |
| spellingShingle | Ziwei Zhang Xiuxiu Zhou Yi Xia Qianxi Jin Yu Guan Taohu Zhou Yueze Li Shiyuan Liu Li Fan Reference ranges of CT quantitative indexes based on paired inspiratory and expiratory chest CT in healthy Chinese adults: A community-based cohort study Meta-Radiology Reference range Chest phantom Paired inspiratory and expiratory chest CT |
| title | Reference ranges of CT quantitative indexes based on paired inspiratory and expiratory chest CT in healthy Chinese adults: A community-based cohort study |
| title_full | Reference ranges of CT quantitative indexes based on paired inspiratory and expiratory chest CT in healthy Chinese adults: A community-based cohort study |
| title_fullStr | Reference ranges of CT quantitative indexes based on paired inspiratory and expiratory chest CT in healthy Chinese adults: A community-based cohort study |
| title_full_unstemmed | Reference ranges of CT quantitative indexes based on paired inspiratory and expiratory chest CT in healthy Chinese adults: A community-based cohort study |
| title_short | Reference ranges of CT quantitative indexes based on paired inspiratory and expiratory chest CT in healthy Chinese adults: A community-based cohort study |
| title_sort | reference ranges of ct quantitative indexes based on paired inspiratory and expiratory chest ct in healthy chinese adults a community based cohort study |
| topic | Reference range Chest phantom Paired inspiratory and expiratory chest CT |
| url | http://www.sciencedirect.com/science/article/pii/S2950162825000220 |
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