Quality by design enabled formulation development of regorafenib monohydrate loaded PEGylated PLGA polymeric nanoparticles: Enhanced oral bioavailability and biopharmaceutical attributes

Quality by design enabled formulation development of regorafenib monohydrate loaded PEGylated PLGA polymeric nanoparticles: Enhanced oral bioavailability and biopharmaceutical attributes

Objective(s): Using a quality-by-design methodology, the current research is aimed to prepare and enhance the PEGylated PLGA-loaded regorafenib monohydrate polymeric nanoparticles for enhancing oral bioavailability and biopharmaceutical attributes. The oral multi-kinase inhibitor inhibits VEGFR2-TIE...

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Bibliographic Details
Main Authors: Dhananjay Panigrahi, Suryakanta Swain, Pratap Sahu, Debashish Ghose, Bikash Ranjan Jena
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2024-10-01
Series:Nanomedicine Journal
Subjects:
bioavailability potential
polymeric nanoparticles
quality by design
regorafenib monohydrate
zeta potential  
Online Access:https://nmj.mums.ac.ir/article_24729_285ef57c987090066db90e2add2fc123.pdf
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