In Situ Growth of The Interpenetrating Structure UiO‐66‐NH2/MWCNTs‐OH for The Detection of Phosphoproteins in Human Sweat
Abstract Phosphorylated proteins in human sweat are found to be closely associated with neurodegenerative diseases, including Alzheimer's disease. Real‐time, non‐invasive detection of changes in the types and levels of phosphorylated proteins in sweat is of significant clinical value for the pr...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-04-01
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| Series: | Advanced Sensor Research |
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| Online Access: | https://doi.org/10.1002/adsr.202400130 |
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| author | Zhiye Ying Ce Bian Lijuan Qiao Bingxin Liu Li Gao |
| author_facet | Zhiye Ying Ce Bian Lijuan Qiao Bingxin Liu Li Gao |
| author_sort | Zhiye Ying |
| collection | DOAJ |
| description | Abstract Phosphorylated proteins in human sweat are found to be closely associated with neurodegenerative diseases, including Alzheimer's disease. Real‐time, non‐invasive detection of changes in the types and levels of phosphorylated proteins in sweat is of significant clinical value for the prevention and diagnosis of these diseases. This research introduces an electrochemical sensor based on an in situ‐grown interpenetrating network structure of UiO‐66‐NH2/MWCNTs‐OH, specifically designed for detecting phosphorylated proteins in sweat. The sensor is tested with common phosphorylated and non‐phosphorylated proteins, demonstrating excellent selectivity, repeatability, reproducibility, and stability, with a limit of detection as low as 0.28 µmol L−1. Additionally, biotoxicity experiments conducted on SD rats and volunteers show that UiO‐66‐NH2/MWCNTs‐OH is biologically safe, making it suitable for use as a biosensor. Finally, the fabrication of the electrochemical sensing module provides a foundation for the development of subsequent wearable sensors. |
| format | Article |
| id | doaj-art-e3d63667e6354415aa8b2f25326d4c59 |
| institution | OA Journals |
| issn | 2751-1219 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Sensor Research |
| spelling | doaj-art-e3d63667e6354415aa8b2f25326d4c592025-08-20T02:09:29ZengWiley-VCHAdvanced Sensor Research2751-12192025-04-0144n/an/a10.1002/adsr.202400130In Situ Growth of The Interpenetrating Structure UiO‐66‐NH2/MWCNTs‐OH for The Detection of Phosphoproteins in Human SweatZhiye Ying0Ce Bian1Lijuan Qiao2Bingxin Liu3Li Gao4School of Mechanical Engineering Qinghai University Xining 810016 P. R. ChinaSchool of Mechanical Engineering Qinghai University Xining 810016 P. R. ChinaResearch Center of Basic Medical Science Medical College Qinghai University Xining 810016 P. R. ChinaSchool of Mechanical Engineering Qinghai University Xining 810016 P. R. ChinaSchool of Mechanical Engineering Qinghai University Xining 810016 P. R. ChinaAbstract Phosphorylated proteins in human sweat are found to be closely associated with neurodegenerative diseases, including Alzheimer's disease. Real‐time, non‐invasive detection of changes in the types and levels of phosphorylated proteins in sweat is of significant clinical value for the prevention and diagnosis of these diseases. This research introduces an electrochemical sensor based on an in situ‐grown interpenetrating network structure of UiO‐66‐NH2/MWCNTs‐OH, specifically designed for detecting phosphorylated proteins in sweat. The sensor is tested with common phosphorylated and non‐phosphorylated proteins, demonstrating excellent selectivity, repeatability, reproducibility, and stability, with a limit of detection as low as 0.28 µmol L−1. Additionally, biotoxicity experiments conducted on SD rats and volunteers show that UiO‐66‐NH2/MWCNTs‐OH is biologically safe, making it suitable for use as a biosensor. Finally, the fabrication of the electrochemical sensing module provides a foundation for the development of subsequent wearable sensors.https://doi.org/10.1002/adsr.202400130MWCNTs‐OHphosphoproteinsweat sensorsUiO‐66‐NH2 |
| spellingShingle | Zhiye Ying Ce Bian Lijuan Qiao Bingxin Liu Li Gao In Situ Growth of The Interpenetrating Structure UiO‐66‐NH2/MWCNTs‐OH for The Detection of Phosphoproteins in Human Sweat Advanced Sensor Research MWCNTs‐OH phosphoprotein sweat sensors UiO‐66‐NH2 |
| title | In Situ Growth of The Interpenetrating Structure UiO‐66‐NH2/MWCNTs‐OH for The Detection of Phosphoproteins in Human Sweat |
| title_full | In Situ Growth of The Interpenetrating Structure UiO‐66‐NH2/MWCNTs‐OH for The Detection of Phosphoproteins in Human Sweat |
| title_fullStr | In Situ Growth of The Interpenetrating Structure UiO‐66‐NH2/MWCNTs‐OH for The Detection of Phosphoproteins in Human Sweat |
| title_full_unstemmed | In Situ Growth of The Interpenetrating Structure UiO‐66‐NH2/MWCNTs‐OH for The Detection of Phosphoproteins in Human Sweat |
| title_short | In Situ Growth of The Interpenetrating Structure UiO‐66‐NH2/MWCNTs‐OH for The Detection of Phosphoproteins in Human Sweat |
| title_sort | in situ growth of the interpenetrating structure uio 66 nh2 mwcnts oh for the detection of phosphoproteins in human sweat |
| topic | MWCNTs‐OH phosphoprotein sweat sensors UiO‐66‐NH2 |
| url | https://doi.org/10.1002/adsr.202400130 |
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