Regulation of the immune microenvironment and immunotherapy after liver transplantation
Liver transplantation (LT) is a primary treatment option for patients with end-stage liver disease. However, post-transplantation immune regulation is critical to graft survival and long-term patient outcomes. Following liver transplantation, the recipient’s immune system mounts a response against t...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1602877/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849728124492709888 |
|---|---|
| author | Tianyi Lan Tianyi Lan Gang Wu Gang Wu Bangyou Zuo Jingming Yang Jingming Yang Pan He Pan He Yu Zhang Yu Zhang |
| author_facet | Tianyi Lan Tianyi Lan Gang Wu Gang Wu Bangyou Zuo Jingming Yang Jingming Yang Pan He Pan He Yu Zhang Yu Zhang |
| author_sort | Tianyi Lan |
| collection | DOAJ |
| description | Liver transplantation (LT) is a primary treatment option for patients with end-stage liver disease. However, post-transplantation immune regulation is critical to graft survival and long-term patient outcomes. Following liver transplantation, the recipient’s immune system mounts a response against the graft, while the graft promotes anti-rejection immune reactions and the establishment of immune tolerance. In recent years, advances in the study of the immune microenvironment have provided new insights into post-transplantation immune regulation. Meanwhile, immunotherapy strategies have opened new possibilities for improving transplantation success rates and long-term survival. This review summarizes recent progress in understanding the immune microenvironment and immunotherapy following liver transplantation, focusing on key components of the transplant immune microenvironment, their regulatory networks and mechanisms, major immunosuppressive strategies, emerging immunotherapeutic approaches, and current challenges. The aim was to provide a theoretical foundation for optimizing clinical practice. |
| format | Article |
| id | doaj-art-e3d5f6e6f9eb42b7bbd34d5a62c8030e |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-e3d5f6e6f9eb42b7bbd34d5a62c8030e2025-08-20T03:09:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.16028771602877Regulation of the immune microenvironment and immunotherapy after liver transplantationTianyi Lan0Tianyi Lan1Gang Wu2Gang Wu3Bangyou Zuo4Jingming Yang5Jingming Yang6Pan He7Pan He8Yu Zhang9Yu Zhang10Department of Hepatobiliary and Pancreatic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSouthwest Medical University, Luzhou, Sichuan, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaLiver transplantation (LT) is a primary treatment option for patients with end-stage liver disease. However, post-transplantation immune regulation is critical to graft survival and long-term patient outcomes. Following liver transplantation, the recipient’s immune system mounts a response against the graft, while the graft promotes anti-rejection immune reactions and the establishment of immune tolerance. In recent years, advances in the study of the immune microenvironment have provided new insights into post-transplantation immune regulation. Meanwhile, immunotherapy strategies have opened new possibilities for improving transplantation success rates and long-term survival. This review summarizes recent progress in understanding the immune microenvironment and immunotherapy following liver transplantation, focusing on key components of the transplant immune microenvironment, their regulatory networks and mechanisms, major immunosuppressive strategies, emerging immunotherapeutic approaches, and current challenges. The aim was to provide a theoretical foundation for optimizing clinical practice.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1602877/fullend-stage liver diseaseliver transplantationimmune microenvironmentimmune regulationimmunotherapy |
| spellingShingle | Tianyi Lan Tianyi Lan Gang Wu Gang Wu Bangyou Zuo Jingming Yang Jingming Yang Pan He Pan He Yu Zhang Yu Zhang Regulation of the immune microenvironment and immunotherapy after liver transplantation Frontiers in Immunology end-stage liver disease liver transplantation immune microenvironment immune regulation immunotherapy |
| title | Regulation of the immune microenvironment and immunotherapy after liver transplantation |
| title_full | Regulation of the immune microenvironment and immunotherapy after liver transplantation |
| title_fullStr | Regulation of the immune microenvironment and immunotherapy after liver transplantation |
| title_full_unstemmed | Regulation of the immune microenvironment and immunotherapy after liver transplantation |
| title_short | Regulation of the immune microenvironment and immunotherapy after liver transplantation |
| title_sort | regulation of the immune microenvironment and immunotherapy after liver transplantation |
| topic | end-stage liver disease liver transplantation immune microenvironment immune regulation immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1602877/full |
| work_keys_str_mv | AT tianyilan regulationoftheimmunemicroenvironmentandimmunotherapyafterlivertransplantation AT tianyilan regulationoftheimmunemicroenvironmentandimmunotherapyafterlivertransplantation AT gangwu regulationoftheimmunemicroenvironmentandimmunotherapyafterlivertransplantation AT gangwu regulationoftheimmunemicroenvironmentandimmunotherapyafterlivertransplantation AT bangyouzuo regulationoftheimmunemicroenvironmentandimmunotherapyafterlivertransplantation AT jingmingyang regulationoftheimmunemicroenvironmentandimmunotherapyafterlivertransplantation AT jingmingyang regulationoftheimmunemicroenvironmentandimmunotherapyafterlivertransplantation AT panhe regulationoftheimmunemicroenvironmentandimmunotherapyafterlivertransplantation AT panhe regulationoftheimmunemicroenvironmentandimmunotherapyafterlivertransplantation AT yuzhang regulationoftheimmunemicroenvironmentandimmunotherapyafterlivertransplantation AT yuzhang regulationoftheimmunemicroenvironmentandimmunotherapyafterlivertransplantation |