Positive association between the neutrophil percentage-to-albumin ratio and constipation: a retrospective cross-sectional study
IntroductionThe neutrophil-to-albumin ratio (NPAR), a novel marker of systemic inflammation, has been utilized to predict outcomes in patients with cancer and cardiovascular diseases. Since inflammation plays a critical role in the pathogenesis of constipation, understanding its connection to NPAR i...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1582175/full |
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| author | Yuping Shu Zuqing Chen Minyuan Lu Nai Mi Yong Wan Wei Shen Zewei Sheng Zewei Sheng Hongwu Tao Xuefeng Liu Xuefeng Liu Yuedong Liu |
| author_facet | Yuping Shu Zuqing Chen Minyuan Lu Nai Mi Yong Wan Wei Shen Zewei Sheng Zewei Sheng Hongwu Tao Xuefeng Liu Xuefeng Liu Yuedong Liu |
| author_sort | Yuping Shu |
| collection | DOAJ |
| description | IntroductionThe neutrophil-to-albumin ratio (NPAR), a novel marker of systemic inflammation, has been utilized to predict outcomes in patients with cancer and cardiovascular diseases. Since inflammation plays a critical role in the pathogenesis of constipation, understanding its connection to NPAR is essential. However, the association between NPAR and constipation remains unclear. This study aims to investigate the potential relationship between NPAR and constipation.MethodData from the 2009–2010 National Health and Nutrition Examination Survey (NHANES) were utilized for this study. The neutrophil-to-albumin ratio (NPAR) was calculated as the ratio of the neutrophil percentage to serum albumin levels. To investigate the relationship between NPAR and chronic constipation, various statistical methods were applied, including interaction tests, subgroup analyses, and curve fitting techniques.ResultsAmong the 5,011 participants included in the analysis, 366 (7.30%) were identified as having chronic constipation. Higher NPAR levels were significantly associated with an increased likelihood of chronic constipation (OR = 1.05, 95% CI: 1.01–1.10, p < 0.05) based on a fully adjusted multiple logistic regression model. Further adjustments revealed that participants in the highest tertile of NPAR had an odds ratio of 1.31 (95% CI: 1.00–1.72, p < 0.05) for chronic constipation compared to those in the lowest tertile. Subgroup analyses indicated no significant association in most groups. However, a positive relationship between NPAR and chronic constipation was observed in specific subgroups, including individuals of Other Hispanic ethnicity, smokers, those with heart disease, alcohol consumers, diabetics, and those who were never married.ConclusionThis study identified a significant positive association between NPAR and the prevalence of chronic constipation. These findings suggest that NPAR may serve as a potential inflammatory biomarker for chronic constipation. Further prospective research is necessary to clarify the long-term implications of elevated NPAR levels on chronic constipation. |
| format | Article |
| id | doaj-art-e3d595a87def4775938d5b0e65ef5807 |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-e3d595a87def4775938d5b0e65ef58072025-08-20T03:17:39ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.15821751582175Positive association between the neutrophil percentage-to-albumin ratio and constipation: a retrospective cross-sectional studyYuping Shu0Zuqing Chen1Minyuan Lu2Nai Mi3Yong Wan4Wei Shen5Zewei Sheng6Zewei Sheng7Hongwu Tao8Xuefeng Liu9Xuefeng Liu10Yuedong Liu11The Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaThe Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaThe Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaXinjiang Production and Construction Corps Fifth Division Hospital Respiratory Geriatrics Department, Xinjiang, ChinaThe Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaThe Proctology Department of Handan Traditional Chinese Medicine Hospital, Handan, ChinaLiaoning University of Traditional Chinese Medicine, Second Clinical College, Shenyang, ChinaThird Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, ChinaLiaoning University of Traditional Chinese Medicine, Second Clinical College, Shenyang, ChinaLiaoning University of Traditional Chinese Medicine, Second Clinical College, Shenyang, ChinaThird Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, ChinaThird Affiliated Hospital, Liaoning University of Traditional Chinese Medicine, Shenyang, ChinaIntroductionThe neutrophil-to-albumin ratio (NPAR), a novel marker of systemic inflammation, has been utilized to predict outcomes in patients with cancer and cardiovascular diseases. Since inflammation plays a critical role in the pathogenesis of constipation, understanding its connection to NPAR is essential. However, the association between NPAR and constipation remains unclear. This study aims to investigate the potential relationship between NPAR and constipation.MethodData from the 2009–2010 National Health and Nutrition Examination Survey (NHANES) were utilized for this study. The neutrophil-to-albumin ratio (NPAR) was calculated as the ratio of the neutrophil percentage to serum albumin levels. To investigate the relationship between NPAR and chronic constipation, various statistical methods were applied, including interaction tests, subgroup analyses, and curve fitting techniques.ResultsAmong the 5,011 participants included in the analysis, 366 (7.30%) were identified as having chronic constipation. Higher NPAR levels were significantly associated with an increased likelihood of chronic constipation (OR = 1.05, 95% CI: 1.01–1.10, p < 0.05) based on a fully adjusted multiple logistic regression model. Further adjustments revealed that participants in the highest tertile of NPAR had an odds ratio of 1.31 (95% CI: 1.00–1.72, p < 0.05) for chronic constipation compared to those in the lowest tertile. Subgroup analyses indicated no significant association in most groups. However, a positive relationship between NPAR and chronic constipation was observed in specific subgroups, including individuals of Other Hispanic ethnicity, smokers, those with heart disease, alcohol consumers, diabetics, and those who were never married.ConclusionThis study identified a significant positive association between NPAR and the prevalence of chronic constipation. These findings suggest that NPAR may serve as a potential inflammatory biomarker for chronic constipation. Further prospective research is necessary to clarify the long-term implications of elevated NPAR levels on chronic constipation.https://www.frontiersin.org/articles/10.3389/fmed.2025.1582175/fullNHANESNPARconstipationrisk factorcross-sectional study |
| spellingShingle | Yuping Shu Zuqing Chen Minyuan Lu Nai Mi Yong Wan Wei Shen Zewei Sheng Zewei Sheng Hongwu Tao Xuefeng Liu Xuefeng Liu Yuedong Liu Positive association between the neutrophil percentage-to-albumin ratio and constipation: a retrospective cross-sectional study Frontiers in Medicine NHANES NPAR constipation risk factor cross-sectional study |
| title | Positive association between the neutrophil percentage-to-albumin ratio and constipation: a retrospective cross-sectional study |
| title_full | Positive association between the neutrophil percentage-to-albumin ratio and constipation: a retrospective cross-sectional study |
| title_fullStr | Positive association between the neutrophil percentage-to-albumin ratio and constipation: a retrospective cross-sectional study |
| title_full_unstemmed | Positive association between the neutrophil percentage-to-albumin ratio and constipation: a retrospective cross-sectional study |
| title_short | Positive association between the neutrophil percentage-to-albumin ratio and constipation: a retrospective cross-sectional study |
| title_sort | positive association between the neutrophil percentage to albumin ratio and constipation a retrospective cross sectional study |
| topic | NHANES NPAR constipation risk factor cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1582175/full |
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