Enrichment of ornithine decarboxylase degron transduced colorectal cancer cells for extended application of cancer stem cell models

Enrichment of ornithine decarboxylase degron transduced colorectal cancer cells for extended application of cancer stem cell models

Abstract Cancer stem cells (CSCs) are present in small quantities in tumor populations. To permit various analyses of CSCs, we attempted to enrich and expand ornithine decarboxylase (ODC) degron-transduced colorectal cancer (CRC) cells, which retain low proteasome activity. ZsGreen fluorescence-posi...

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Main Authors: Ryo Ikeshima, Hidekazu Takahashi, Hiroyuki Yamamoto, Shihori Kouda, Rika Akisue, Manami Tsujimoto, Yuhki Yokoyama, Haruka Hirose, Hiroaki Itakura, Yoshihiro Morimoto, Norikatsu Miyoshi, Mamoru Uemura, Daisuke Okuzaki, Shinji Tanaka, Hidetoshi Eguchi, Yuichiro Doki, Hirofumi Yamamoto, Masaki Mori
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-04277-w
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https://doi.org/10.1038/s41598-025-04277-w

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