Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials
The transplantation of neural stem cells (NSCs) has become an emerging treatment for neural degeneration. A key factor in such treatments is to manipulate NSC behaviors such as proliferation and differentiation, resulting in the eventual regulation of NSC fate. Novel bionanomaterials have shown usef...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/3608386 |
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| author | Lin Xia Wenjuan Zhu Yunfeng Wang Shuangba He Renjie Chai |
| author_facet | Lin Xia Wenjuan Zhu Yunfeng Wang Shuangba He Renjie Chai |
| author_sort | Lin Xia |
| collection | DOAJ |
| description | The transplantation of neural stem cells (NSCs) has become an emerging treatment for neural degeneration. A key factor in such treatments is to manipulate NSC behaviors such as proliferation and differentiation, resulting in the eventual regulation of NSC fate. Novel bionanomaterials have shown usefulness in guiding the proliferation and differentiation of NSCs due to the materials’ unique morphological and topological properties. Among the nanomaterials, graphene has drawn increasing attention for neural regeneration applications based on the material’s excellent physicochemical properties, surface modifications, and biocompatibility. In this review, we summarize recent works on the use of graphene-based biomaterials for regulating NSC behaviors and the potential use of these materials in clinical treatment. We also discuss the limitations of graphene-based nanomaterials for use in clinical practice. Finally, we provide some future prospects for graphene-based biomaterial applications in neural regeneration. |
| format | Article |
| id | doaj-art-e3d30dfa35524c8788605d5dbd7f5656 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e3d30dfa35524c8788605d5dbd7f56562025-08-20T03:26:34ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/36083863608386Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based BiomaterialsLin Xia0Wenjuan Zhu1Yunfeng Wang2Shuangba He3Renjie Chai4State Key Laboratory of Bioelectronics, MOE Key Laboratory for Developmental Genes and Human Disease, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 210096, ChinaZhangjiagang City First People’s Hospital, The Affiliated Zhangjiagang Hospital of Suzhou University, Zhangjiagang 215600, ChinaENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, ChinaDepartment of Otolaryngology Head and Neck, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing 211102, ChinaState Key Laboratory of Bioelectronics, MOE Key Laboratory for Developmental Genes and Human Disease, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 210096, ChinaThe transplantation of neural stem cells (NSCs) has become an emerging treatment for neural degeneration. A key factor in such treatments is to manipulate NSC behaviors such as proliferation and differentiation, resulting in the eventual regulation of NSC fate. Novel bionanomaterials have shown usefulness in guiding the proliferation and differentiation of NSCs due to the materials’ unique morphological and topological properties. Among the nanomaterials, graphene has drawn increasing attention for neural regeneration applications based on the material’s excellent physicochemical properties, surface modifications, and biocompatibility. In this review, we summarize recent works on the use of graphene-based biomaterials for regulating NSC behaviors and the potential use of these materials in clinical treatment. We also discuss the limitations of graphene-based nanomaterials for use in clinical practice. Finally, we provide some future prospects for graphene-based biomaterial applications in neural regeneration.http://dx.doi.org/10.1155/2019/3608386 |
| spellingShingle | Lin Xia Wenjuan Zhu Yunfeng Wang Shuangba He Renjie Chai Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials Neural Plasticity |
| title | Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials |
| title_full | Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials |
| title_fullStr | Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials |
| title_full_unstemmed | Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials |
| title_short | Regulation of Neural Stem Cell Proliferation and Differentiation by Graphene-Based Biomaterials |
| title_sort | regulation of neural stem cell proliferation and differentiation by graphene based biomaterials |
| url | http://dx.doi.org/10.1155/2019/3608386 |
| work_keys_str_mv | AT linxia regulationofneuralstemcellproliferationanddifferentiationbygraphenebasedbiomaterials AT wenjuanzhu regulationofneuralstemcellproliferationanddifferentiationbygraphenebasedbiomaterials AT yunfengwang regulationofneuralstemcellproliferationanddifferentiationbygraphenebasedbiomaterials AT shuangbahe regulationofneuralstemcellproliferationanddifferentiationbygraphenebasedbiomaterials AT renjiechai regulationofneuralstemcellproliferationanddifferentiationbygraphenebasedbiomaterials |