Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational Studies
Purpose. Systematic reviews of case-control and prospective studies showed a positive association between habitual salt intake and gastric cancer. Given new studies published thereafter, we carried out a meta-analysis to assess the association between dietary salt intake and gastric cancer. Methods....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/808120 |
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| _version_ | 1849434798463909888 |
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| author | Sheng Ge Xiaohui Feng Li Shen Zhanying Wei Qiankun Zhu Juan Sun |
| author_facet | Sheng Ge Xiaohui Feng Li Shen Zhanying Wei Qiankun Zhu Juan Sun |
| author_sort | Sheng Ge |
| collection | DOAJ |
| description | Purpose. Systematic reviews of case-control and prospective studies showed a positive association between habitual salt intake and gastric cancer. Given new studies published thereafter, we carried out a meta-analysis to assess the association between dietary salt intake and gastric cancer. Methods. Case-control studies and cohort studies published between January 1992 and January 2012 on PubMed and Embase were searched. We quantified associations between salt intake and gastric cancer with meta-analysis. Results. Eleven studies (7 case controls and 4 cohorts) finally were included in the meta-analysis (total population: n=2076498; events: n=12039). The combined odds ratio showed significantly positive association between high salt intake and gastric cancer compared with low salt intake (OR = 2.05, 95% CI [1.60, 2.62]; P<0.00001). In subgroup meta-analysis, findings were slightly different when analyses were restricted to salty food intake (OR = 2.41, 95% CI [2.08, 2.78]; P<0.00001) as well as in Asia (OR = 1.27 95% CI [1.22, 1.32]; P<0.00001). There was no evidence that sample size, exposure assessment substantially influenced the estimate of effects. Conclusions. The systemic review supports the hypothesis that dietary salt intake is positively associated with the risk of gastric cancer. |
| format | Article |
| id | doaj-art-e3cfde571b9b4fa3857e3a50ace231c9 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e3cfde571b9b4fa3857e3a50ace231c92025-08-20T03:26:31ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/808120808120Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational StudiesSheng Ge0Xiaohui Feng1Li Shen2Zhanying Wei3Qiankun Zhu4Juan Sun5Department of Clinical Nutrition, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, ChinaDepartment of Clinical Nutrition, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, ChinaDepartment of Clinical Nutrition, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, ChinaDepartment of Clinical Nutrition, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, ChinaDepartment of Clinical Nutrition, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, ChinaDepartment of Clinical Nutrition, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai 200233, ChinaPurpose. Systematic reviews of case-control and prospective studies showed a positive association between habitual salt intake and gastric cancer. Given new studies published thereafter, we carried out a meta-analysis to assess the association between dietary salt intake and gastric cancer. Methods. Case-control studies and cohort studies published between January 1992 and January 2012 on PubMed and Embase were searched. We quantified associations between salt intake and gastric cancer with meta-analysis. Results. Eleven studies (7 case controls and 4 cohorts) finally were included in the meta-analysis (total population: n=2076498; events: n=12039). The combined odds ratio showed significantly positive association between high salt intake and gastric cancer compared with low salt intake (OR = 2.05, 95% CI [1.60, 2.62]; P<0.00001). In subgroup meta-analysis, findings were slightly different when analyses were restricted to salty food intake (OR = 2.41, 95% CI [2.08, 2.78]; P<0.00001) as well as in Asia (OR = 1.27 95% CI [1.22, 1.32]; P<0.00001). There was no evidence that sample size, exposure assessment substantially influenced the estimate of effects. Conclusions. The systemic review supports the hypothesis that dietary salt intake is positively associated with the risk of gastric cancer.http://dx.doi.org/10.1155/2012/808120 |
| spellingShingle | Sheng Ge Xiaohui Feng Li Shen Zhanying Wei Qiankun Zhu Juan Sun Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational Studies Gastroenterology Research and Practice |
| title | Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational Studies |
| title_full | Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational Studies |
| title_fullStr | Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational Studies |
| title_full_unstemmed | Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational Studies |
| title_short | Association between Habitual Dietary Salt Intake and Risk of Gastric Cancer: A Systematic Review of Observational Studies |
| title_sort | association between habitual dietary salt intake and risk of gastric cancer a systematic review of observational studies |
| url | http://dx.doi.org/10.1155/2012/808120 |
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